Análise da invasão da artéria carótida por metástases linfonodais de carcinoma epidermóide de vias aero-digestivas superiores

Invasão carotídea por linfonodos metastáticos altera a abordagem dos tumores de cabeça e pescoço. OBJETIVO: Avaliação interobservadores de imagens de TC do envolvimento do complexo carotídeo por linfonodos metastáticos de neoplasias vias aero-digestivas superiores e estabelecimento de critérios de ressecabilidade cirúrgica. MATERIAL E MÉTODO: Estudo retrospectivo não-randomizado, de 99 pacientes com CEC com linfonodos metastáticos envolvendo o complexo carotídeo. Oitenta e seis casos eram homens e 13 mulheres, idade entre 32 a 76 anos. As imagens foram avaliadas por quatro especialistas sem conhecimento do estadiamento clínico. Os pacientes não receberam tratamento prévio. Quanto à extensão do envolvimento da circunferência da carótida, empregamos 2 classificações: simples (de 0 a 50% e de 51 a 100%), e complexa (de 0 a 25%; de 26 a 50%; de 51 a 75% e de 76 a 100%). O nível de concordância interobservadores foi aferido pelo índice Kappa (p < 0,05) e a força de concordância variou de desprezível à excelente. RESULTADOS: O índice Kappa foi moderado (0,53%) para a classificação simples e mínima (0,036) para a complexa. CONCLUSÃO: A TC mostrou baixa efetividade na avaliação de ressecabilidade quando do comprometimento do complexo carotídeo por linfonodos metastáticos de neoplasias malignas de cabeça e pescoço.

p53 Mutation in histologically normal mucosa of the aero-digestive tract is not a marker of increased risk for second primary carcinoma in head and neck cancer patients.

Head and neck cancer patients are at high risk for developing second primary tumors. This is known as field cancerization of the aero-digestive tract. In a previous study, we showed that patients with multiple primary tumors were more likely to have p53 mutations in histologically normal mucosae than patients presenting with an isolated tumor. Based on this observation, we postulated that p53 mutations in normal tissue samples of patients bearing a single primary tumor could have a clinical value as a biomarker for the risk of developing second primary tumors. Thirty-five patients presenting with a single primary tumor were followed-up for a median of 51 months (range 1 month to 10.9 years) after biopsies of histologically normal squamous cell mucosa had been analyzed for p53 mutations with a yeast functional assay at the time of the primary tumor. During this follow-up, recurrences and non-sterilization of the primary tumor, occurrence of lymph node metastases, and of second primary tumors were evaluated. Sixteen (45.7%) patients were found to have p53 mutations in their normal squamous cell mucosa, and 19 (54.3%) patients showed no mutation. No relationship was found between p53 mutations and the occurrence of evaluated events during follow-up. Notably, the rate of second primary tumors was not associated with p53 mutations in the normal squamous mucosa. The correlation between p53 mutations in histologically normal mucosae and the incidence of second primary tumors is generally low. The benefit of analyzing p53 mutations in samples of normal squamous cell mucosa in every patient with a primary tumor of the head and neck is doubtful.

Diesel hand book; a practical book of instruction for engineers and students on modern Diesel engineering, land, marine, locomotive, aero, automotive and portable installations.

Mode of access: Internet.

Jaguar series IIIA aero engine.

Mode of access: Internet.

Aero engines;

Mode of access: Internet.

Proceedings of the Aero-Optics Symposium on Electromagnetic Wave Propagation from Aircraft, held at Ames Research Center, Moffett Field, California, August 14-15, 1979 /

Includes bibliographical references.

Establishing a framework for dynamic risk management in 'intelligent' aero-engine control

The behaviour of control functions in safety critical software systems is typically bounded to prevent the occurrence of known system level hazards. These bounds are typically derived through safety analyses and can be implemented through the use of necessary design features. However, the unpredictability of real world problems can result in changes in the operating context that may invalidate the behavioural bounds themselves, for example, unexpected hazardous operating contexts as a result of failures or degradation. For highly complex problems it may be infeasible to determine the precise desired behavioural bounds of a function that addresses or minimises risk for hazardous operation cases prior to deployment. This paper presents an overview of the safety challenges associated with such a problem and how such problems might be addressed. A self-management framework is proposed that performs on-line risk management. The features of the framework are shown in context of employing intelligent adaptive controllers operating within complex and highly dynamic problem domains such as Gas-Turbine Aero Engine control. Safety assurance arguments enabled by the framework necessary for certification are also outlined.

Achieving low cost and high quality aero structure assembly through integrated digital metrology systems

Measurement assisted assembly (MAA) has the potential to facilitate a step change in assembly efficiency for large structures such as airframes through the reduction of rework, manually intensive processes and expensive monolithic assembly tooling. It is shown how MAA can enable rapid part-to-part assembly, increased use of flexible automation, traceable quality assurance and control, reduced structure weight and improved aerodynamic tolerances. These advances will require the development of automated networks of measurement instruments; model based thermal compensation, the automatic integration of 'live' measurement data into variation simulation and algorithms to generate cutting paths for predictive shimming and drilling processes. This paper sets out an architecture for digital systems which will enable this integrated approach to variation management. © 2013 The Authors.

Designing low-emission aero-engines using adjoint methods

The aim of this work is to investigate an efficient CAD based adjoint process chain for calculating sensitivities of the objective function to the CAD parameter in time scales acceptable for industrial design processes.

O3b mPOWER Systems - Aero route modelling

The main goal of this internship is to develop a tool to perform a resource usage (and cost) estimation. There has been a major focus in the analysis of the gain levels and on the possibility of an outage. During the evaluation, it is shown that fast gain level adjustment has a major impact on link quality and resource consumption. On top of that, having a random outage during a flight is not a critical condition if even the simplest solution can be applied to overcome and compensate.

ANÁLISE DA QUALIDADE DE VIDA DOS SERVIDORES DA UNIDADE BÁSICA DE SAÚDE DA FAMÍLIA AERO RANCHO IV

O conceito qualidade de vida tem suscitado pesquisas e cresce a sua utilização nas práticas desenvolvidas pelos servidores da saúde, por equipes profissionais que atuam junto a usuários acometidos por enfermidades diversas. As condições laborais, bem como as relações diretas entre os trabalhadores, influenciam diretamente a qualidade de vida. O presente trabalho tem como objetivo analisar a qualidade de vida dos servidores da UBSF – Unidade Básica de Saúde da Família – Aero Rancho IV na cidade de Campo Grande (MS), dando suporte para um futuro trabalho junto a estes profissionais. Quanto aos aspectos metodológicos, foi realizada uma pesquisa quantitativa transversal utilizando a Versão Brasileira do Questionário SF 36 como instrumento de medida e de avaliação da Qualidade de Vida, onde 38 servidores voluntários responderam o questionário na UBSF Aero Rancho IV, representando 73,1% do total de servidores da UBSF. Concluiu-se que os servidores voluntários que participaram desta pesquisa possuem uma boa qualidade de vida, porém se faz necessário uma maior atenção a ergonomia e ao stress destes servidores, situações diretamente relacionadas à Dor e a Saúde Mental. Situações que podem agravar se não houver intervenções junto a estes servidores.