Antibody-mediated rejection (AMR) after pancreas and pancreas-kidney transplantation

P>Antibody-mediated rejection (AMR) requires specific diagnostic tools and treatment and is associated with lower graft survival. We prospectively screened C4d in pancreas (n = 35, in 27 patients) and kidney (n = 33, in 21 patients) for cause biopsies. Serum amylase and lipase, amylasuria, fasting blood glucose (FBG) and 2-h capillary glucose (CG) were also analysed. We found that 27.3% of kidney biopsies and 43% of pancreatic biopsies showed C4d staining (66.7% and 53.3% diffuse in peritubular and interacinar capillaries respectively). Isolated exocrine dysfunction was the main indication for pancreas biopsy (54.3%) and was followed by both exocrine and endocrine dysfunctions (37.1%) and isolated endocrine dysfunction (8.6%). Laboratorial parameters were comparable between T-cell mediated rejection and AMR: amylase 151.5 vs. 149 U/l (P = 0.075), lipase 1120 vs. 1288.5 U/l (P = 0.83), amylasuria variation 46.5 vs. 61% (P = 0.97), FBG 69 vs. 97 mg/dl (P = 0.20) and 2-h CG maximum 149.5 vs. 197.5 mg/dl (P = 0.49) respectively. Amylasuria values after treatment correlated with pancreas allograft loss (P = 0.015). These data suggest that C4d staining should be routinely investigated when pancreas allograft dysfunction is present because of its high detection rate in cases of rejection.

Protocolo de comunicación para AMR

Aquest projecte tracta d'aportar una idea al futur dels comptadors automàtics, on tant el usuaris, com les empreses, tindran un control continu sobre les dades. A més a més s’han buscar sistemes i protocols que realitzin una bona comunicació entre els comptadors automàtics, en aquest punt on entra la tecnologia W-Mbus. Aquesta tecnologia juntament amb els microcontroladors de baix consum, proporcionats per Texas Instruments, són la millor combinació per aconseguir el nostre objectiu.

Avoimen AMR-palvelualustan tiedonsiirtomenetelmien selvitys ja analyysi

Sähköenergiamittareiden etälukuun (AMR) siirtyminen on kasvanut Suomessa, kuten muissakin Euroopan maissa viime vuosina merkittävästi. Tavoitteena on, että vuonna 2014 80 % kaikista Suomen sähköenergiamittareista olisi etäluettavia ja rekisteröisivät tunnittaiset kulutustiedot. AMR-tekniikan avulla voidaan toteuttaa myös muita palveluja kulutustietojen rekisteröinnin lisäksi. AMR-mittareiden etäluenta ja niiden kautta siirrettävät signaalit vaativat mittareilta tiedonsiirtotapoja. Työssä tarkastellaan TeliaSoneran AMR-palvelualustan ominaisuuksia ja arkkitehtuuria. Selvitetään AMR-mittareiden toiminnallisia vaatimuksia ja mahdollisia tiedonsiirtotapoja mittareiden ja etäluentajärjestelmän välillä. Arvioidaan näiden selvitysten perusteella ja myös kustannusten kannalta eri tiedonsiirtomenetelmien soveltuvuutta eri ympäristöihin. Lisäksi suoritetaan arviointi ja käytännön laboratoriotestauksia valitulle sähköverkkoa tiedonsiirrossa hyödyntävälle AMR-mittarille. Tavoitteena on selvittää ja analysoida vertailtavan mittarin yhteensopivuutta TeliaSoneran päätelaitteiden ja AMR-palvelualustan kanssa. Analysoidaan näiden tarkasteltavien mittareiden ominaisuuksia ja elinkaarta. Laboratoriotesteillä selvitetään myös tarkasteltavien sähköverkkotiedonsiirto AMRmittareiden häiriösietoisuutta verkossa esiintyviä häiriöitä vastaan. Näiden pohjalta tehdään johtopäätökset ja suositukset.

Development of an AMR-ACB Array for Gastrointestinal Motility Studies

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Development of an AMR-ACB Array for Gastrointestinal Motility Studies

The association between anisotropic magnetoresistive (AMR) sensor and AC biosusceptometry (ACB) to evaluate gastrointestinal motility is presented. The AMR-ACB system was successfully characterized in a bench-top study, and in vivo results were compared with those obtained by means of simultaneous manometry. Both AMR-ACB and manometry techniques presented high temporal cross correlation between the two periodicals signals (R = 0.9 +/- 0.1; P < 0.05). The contraction frequencies using AMR-ACB were 73.9 +/- 7.6 mHz and using manometry were 73.8 +/- 7.9 mHz during the baseline (r = 98, p < 0.05). The amplitude of contraction using AMR-ACB was 396 +/- 108 mu T.s and using manometry were 540 +/- 198 mmHg.s during the baseline. The amplitudes of signals for AMR-ACB and manometric recordings were similarly increased to 86.4% and 89.3% by neostigmine, and also decreased to 27.2% and 21.4% by hyoscine butylbromide in all animals, respectively. The AMR-ACB array is nonexpensive, portable, and has high-spatiotemporal resolution to provide helpful information about gastrointestinal tract.

AMR-Me inhibits PI3K/Akt signaling in hormone-dependent MCF-7 breast cancer cells and inactivates NF-κB in hormone-independent MDA-MB-231 cells

AMR-Me, a C-28 methylester derivative of triterpenoid compound Amooranin isolated from Amoora rohituka stem bark and the plant has been reported to possess multitude of medicinal properties. Our previous studies have shown that AMR-Me can induce apoptosis through mitochondrial apoptotic and MAPK signaling pathways by regulating the expression of apoptosis related genes in human breast cancer MCF-7 cells. However, the molecular mechanism of AMR-Me induced apoptotic cell death remains unclear. Our results showed that AMR-Me dose-dependently inhibited the proliferation of MCF-7 and MDA-MB-231 cells under serum-free conditions supplemented with 1 nM estrogen (E2) with an IC50 value of 0.15 µM, 0.45 µM, respectively. AMR-Me had minimal effects on human normal breast epithelial MCF-10A + ras and MCF-10A cells with IC50 value of 6 and 6.5 µM, respectively. AMR-Me downregulated PI3K p85, Akt1, and p-Akt in an ERα-independent manner in MCF-7 cells and no change in expression levels of PI3K p85 and Akt were observed in MDA-MB-231 cells treated under similar conditions. The PI3K inhibitor LY294002 suppressed Akt activation similar to AMR-Me and potentiated AMR-Me induced apoptosis in MCF-7 cells. EMSA revealed that AMR-Me inhibited nuclear factor-kappaB (NF-κB) DNA binding activity in MDA-MB-231 cells in a time-dependent manner and abrogated EGF induced NF-κB activation. From these studies we conclude that AMR-Me decreased ERα expression and effectively inhibited Akt phosphorylation in MCF-7 cells and inactivate constitutive nuclear NF-κB and its regulated proteins in MDA-MB-231 cells. Due to this multifactorial effect in hormone-dependent and independent breast cancer cells AMR-Me deserves attention for use in breast cancer prevention and therapy

Amîrā le-vêt Yaʿaqôv : anšprache an das hois Jaʿakov oder di drei bezondern pflichṭen jidišer ehefroien nida, ḥale, hadloke nach dem riṭuale ...

und ins daiṭše iberṭragen fon Zeligman Ber Bamberger

Amîrā le-vêt Yaʿaqôv : anšprache an das hois Jaʿakov oder di drei bezondern pflichṭen jidišer ehefroien nida, ḥale, hadloke ...

bearbeiṭeṭ und in'z daiṭše iberṭragen fon Zeligman Ber Bamberger

Sēfer Be'ēr Mōše : be'ēr ham-millôt ʿal hat-tôrā we-ḥamēš megillôt ... kôl millā ḥamûrā we-qāšā ...

Mōše ... Śerṭilś

Sēfer Maʿaśē hat-tannā'îm we-hā-amôrā'îm

Digitalisat der Ausg. Lemberg, 1896

Lock-in amplifiers for AMR sensors

Anisotropic magnetoresistive (AMR) magnetic sensors are often chosen as the magnetic transducer for magnetic field sensing in applications with low to moderate magnetic field resolution because of the relative low mass of the sensor and their ease of use. They measure magnetic fields in the order of the Earth magnetic field (with typical sensitivities of 1‰/G or 10−2‰/μT), have typical minimum detectable fields in order of nT and even 0.1 nT but they are seriously limited by the thermal drifts due to the variation of the resistivity with temperature (∼2.5‰/°C) and the variation of the magnetoresistive effect with temperature (which affects both the sensitivity of the sensors: ∼2.7‰/°C, and the offset: ±0.5‰/°C). Therefore, for lower magnetic fields, fluxgate vector sensors are generally preferred. In the present work these limitations of AMR sensors are outlined and studied. Three methods based on lock-in amplifiers are proposed as low noise techniques. Their performance has been simulated, experimentally tested and comparatively discussed. The developed model has been also used to derive a technique for temperature compensation of AMR response. The final goal to implement these techniques in a space qualified applied specific integrated circuit (ASIC) for Mars in situ exploration with compact miniaturized magnetometers.

Hādhihī risālah sharīfah fī al-amr bi-al-maʻrūf wa-al-nahy ʻan al-munkar / taʼlīf Shaykh al-Islām wa-al-Muslimīn Najm al-Dīn al-Ghazzī : manuscript, 1658

A treatise on the principle of "commanding right and forbidding wrong" in Islam.