La amenaza de las armas pequeñas, ligeras y explosivos ALP-ME

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Lack of association between lipaemia and central adiposity in subjects with an atherogenic lipoprotein phenotype (ALP)

OBJECTIVE: To investigate the associations between indices of adiposity and cardiovascular risk factors in individuals with an atherogenic lipoprotein phenotype (ALP). SUBJECTS: Fifty-five men, aged 34-69 y, body mass index (BMI) 22-35 kg/m2, with an ALP lipid profile (triglycerides (TG) 1.5-4.0 mmol/l, HDL<1.1 mmol/l; %LDL-3>40% total LDL). DESIGN: Each participant provided a fasting blood sample and underwent an 8 h postprandial assessment and had anthropometric measurements taken. OUTCOME MEASURES: BMI, waist circumference (W), waist-to-hip ratio (W/H), sum of skinfolds (SSK), fasting and postprandial concentrations of glucose, insulin and plasma lipids, post-heparin lipase activity, and apoE genotype. RESULTS: The expected positive associations between BMI, W and SSK and fasting and postprandial insulin were observed (r=0.42-0.65). Little association between glucose responses and any measures of adiposity was evident. Unexpectedly, there were no positive associations between measures of central adiposity (W and W/H) and fasting and postprandial TG responses, with a trend towards negative associations in this study group (TG AUC vs W, r=-0.23, P=0.097; TG IAUC vs W/H, r=-0.26, P=0.068). Subgroup analysis indicated that lack of a positive association between central adiposity and postprandial TG values was more evident in those with one E4 allele (r=-0.42, P=0.077) relative to non-E4 carriers (r=-0.16, P=0.430). The expected positive associations between insulin and TG responses were not observed (r=-0.03 to -0.36). CONCLUSION: In this ALP group the expected positive association between TG responses and a centralized distribution of body fat was not observed, particularly in individuals with an apoE4 genotype. Our findings are not in line with the view that there is a clear causal relationship between insulin resistance and the lipid abnormalities associated with ALP.

The ALP after 2004

In 2004, for the first time in the two decades for which Australian Election Study (AES) data has become available, more blue-collar workers cast their primary vote for the Coalition parties than for Labor. Blue-collar support for Labor had partially recovered under Beazley in 1998 and 2001 following its dramatic drop under Keating in 1996 but it dropped to even lower levels under Latham in 2004. This paper analyses AES survey data, the actual voting results in each federal electorate and the demographic characteristics of those electorates to discuss the nature of Labor’s latest national election defeat and the reasons for it. There is considerable disagreement among commentators as to whether Labor has lost the last four national elections because it has failed to reconnect with its traditional voter base; or because it has failed to go beyond that base. Much of the disagreement centres on how blue-collar workers are to be understood. Are they ‘battlers’ and victims of ‘globalisation’ or have they become prosperous, upwardly-mobile and ‘aspirational’? Related questions include whether the most salient issues for blue-collar voters are economic, or cultural; and whether the most important inequalities in Australian society should be measured in terms of income; or occupation; or geographic location (including degree of distance from the inner-city). This paper analyses the policies presented in the 2004 election and engages with informed journalistic analyses, and contributions from past and present politicians, in addition to the work of political scientists, to help make sense of precisely where and why Labor lost support in 2004 and the implications this has for future ALP policy and strategy. The paper also contributes to the longer-term debates about the reasons for Howard’s electoral ascendancy since 1996; and the role and constituency of Pauline Hanson’s One Nation Party.

Winners and losers : the ALP leadership spill and the triumph of the insiders

Julia Gillard won an impressive victory today, one that Kevin Rudd will find it very difficult to come back from. The scale of her victory contrasted with support for Rudd among the broader public or even among Labor voters.

Durch Schaden wird man klug: Aus dem badischen Oberlande wird vom 15. Juni geschrieben: "Der uns drückende Alp wird etwas erträglicher ..."

Welsch (Projektbearbeiter): Warnung vor der Revolution, d.h. insbesondere vor ihrer radikaldemokratisch-republikanisch-sozialistischen Richtung; Abdruck von Zitaten aus Briefen (Baden) sowie aus dem 'Manifest der Deutschen Demokraten im Auslande' (Genf) und deren Kommentierung im antirevolutionärem Sinne

Adherence to HIV /AIDS therapies among low -literacy populations: The ALP project

Adherence to HIV/AIDS therapies has been an important health problem since the early 1980s when AZT was first prescribed as a therapy for HIV/AIDS. It became particularly important between 1995 and 1997 with the advent of protease inhibitors (Chesney, Ickovics, Hecht, Sikipa, & Rabkin J., 1999) and became even more significant as persons with HIV/AIDS began to develop resistance to medications. Low-literacy populations have poorer health (Brez & Taylor, 1997) and higher AIDS rates (Simon, Hu, Diaz, & Kerndt, 1995), than their higher literacy counterparts due to delayed treatment (Baker, Parker, Williams, Clark, & Nurss, 1997), shame of literacy skills (Parikh, 1996), and poor access to care (Williams, et al., 1995). Poorer health and higher AIDS rates can also be attributed to poor patient-provider relationships (Crespo-Fierro, 1997; Eldred, Wu, Chaisson, & Moore, 1998) to a poorer understanding of medical protocols (Murphy, 1997), and inadequate patient education (Ungvarski, 1997; Davis, Michielutte, Askov, Williams, & Weiss, 1998, Doak, Doak, & Root, 1996). ^ The ALP intervention was developed for HIV positive low-literacy populations of African American women in Houston, Texas. The intervention was based on a needs assessment, using the PRECEDE model, an innovative process referred to as Intervention Mapping, and validated using formative evaluation methods with 54 individuals. The needs assessment resulted in a list of behavioral, environmental, predisposing, enabling, and reinforcing determinants of adherence. The Intervention Mapping framework was used to refine these determinants and develop a list of objectives describing what must be learned or changed to for the target population to adhere to HIV/AIDS therapies. Methods and strategies, were developed using theoretical constructs from the Health Belief Model (Rosenstock, 1974) and Social Cognitive Theory (Bandura, 1986). These theories, empirical evidence, and information from the target population indicated that perceived susceptibility, perceived severity, outcome expectations, and self-efficacy were important and changeable determinants of adherence to HIV/AIDS therapies for this population. ^ These components were brought together in the form of a theory-based color cartoon book and 10-minute cassette tape. The book was developed for people with 2.9 years of U.S. education as measured with the Flesch-Kincaid Grade Level method and the script was recorded onto a cassette tape to make it suitable for populations with even lower-literacy skills. A formative evaluation was conducted to ensure that the content and structure were accurate, clear, realistic, readable, appropriate, and likely to be used as intended. ^