999 resultados para 675


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Visa a esclarecer as disposições constantes da Medida Provisória nº 675, de 21 de maio de 2015, que “Altera a Lei nº 7.689, de 15 de dezembro de 1988, para elevar a alíquota da Contribuição Social sobre o Lucro Líquido – CSLL em relação às pessoas jurídicas de seguros privados e de capitalização e às referidas nos incisos I a VII, IX e X do § 1º do art. 1º da Lei Complementar nº 105, de 10 de janeiro de 2001”.

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Os constituintes começaram a modificar o texto apresentado. Foram confirmados 24 itens do capítulo dos direitos e garantias individuais. Não houve acordo em dois pontos: a necessidade de mandado judicial para prisão e a aplicação imediata destas normas, o mandado de injunção será definido só no voto. Há uma preocupação com a constante falta de quórum.

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Versión en inglés disponible en Biblioteca

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Spanish version available

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IL-23 is a heterodimeric cytokine involved in inflammatory diseases; its role in cancer progression is controversial. Here we analyse the expression of IL-23 subunits (p40 and p19) and IL-23R in colorectal cancer with regard to disease progression, clinical-pathological and molecular aspects. Immunohistochemistry for IL-23p19, IL-23p40, IL-23R and CD8 was performed on a multi-punch tissue microarray of 195 colorectal cancers (cohort 1), matched normal tissue, adenoma and lymph node metastases. Results were compared with clinical-pathological features and CD8+ T-cell counts, then validated on two patient cohorts (cohort 2: n=341, cohort 3: n=139). Cytoplasmic/membranous expression of IL-23 (p19 and p40 subunits) and IL-23R, respectively were over-expressed in carcinomas versus adenomas and normal tissues (p<0.0001) but were reduced in lymph node metastases (p<0.0001). Nuclear IL-23p19 expression was observed in 23.1% and was associated with early TNM stage (p=0.0186), absence of venous (p=0.0124) and lymphatic invasion (p=0.01493), favorable survival (p=0.014) and absence of distant metastasis (p=0.0146; specificity: 100%). This unexpected cellular localization was confirmed by cell fractionation. The beneficial effect of nuclear IL-23p19 was restricted to tumours with CD8+ high counts. Results were validated on Cohorts 2/3. This multicenter study underlines the possible CD8(+)--dependency and beneficial effect of nuclear IL-23p19 on overall patient survival.

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Digitalisat der Ausg. Warša, [1913/14]

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Institut of Social Research: "Studies in Antisemitism. Volume II: III. American Antisemitic Agitators"; enthält: Studien über Martin Luther Thomas, Georg Allison Phelps und 'Conversations with Antisemitis'; Typoskript, gebunden, 436 Blatt;

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On the basis of the BBGKY hierarchy of equations an expression is derived for the response of a fully ionized plasma to a strong, high-frequency electric field in the limit of infinite ion mass. It is found that even in this limit the ionion correlation function is substantially affected by the field. The corrections to earlier nonlinear results for the current density appear to be quite ssential. The validity of the model introduced by Dawson and Oberman to study the response to a vanishingly small field is confirmed for larger values of the field when the eorrect expression for the ion-ion correlations i s introduced; the model by itself does not yield such an expression. The results have interest for the heating of the plasma and for the propagation of a strong electromagnetic wave through the plasma. The theory seems to be valid for any field intensity for which the plasma is stable.