Non-linkage of insulin receptor locus with essential hypertension in an affected pedigree

A recent cross-sectional study has demonstrated a significant association of the R1 RsaI restriction fragment length polymorphism of the insulin receptor gene (INSR) with human essential hypertension. In the present study, an alternative approach, involving linkage analysis, was carried out using 8 hypertensive families with 5 or more affected members. Five of the families were found to be informative and in one of these pedigrees a conclusion of non-linkage of INSR and hypertension could be made on the basis of an obligate recombinant in one generation which yielded a Lod score of - ∞ at a recombination fraction (θ) of zero. In another family, the largest studied, a positive Lod score was obtained at θ = 0, but this was below the level required for a conclusion of linkage. Lod score at θ = 0 for a marker at the insulin locus in this family was negative. The present study has thus demonstrated one pedigree in which hypertension is not linked to the insulin receptor locus.

Compact universal logic gates realized using quantization of current in nanodevices

This paper proposes novel universal logic gates using the current quantization characteristics of nanodevices. In nanodevices like the electron waveguide (EW) and single-electron (SE) turnstile, the channel current is a staircase quantized function of its control voltage. We use this unique characteristic to compactly realize Boolean functions. First we present the concept of the periodic-threshold threshold logic gate (PTTG), and we build a compact PTTG using EW and SE turnstiles. We show that an arbitrary three-input Boolean function can be realized with a single PTTG, and an arbitrary four-input Boolean function can be realized by using two PTTGs. We then use one PTTG to build a universal programmable two-input logic gate which can be used to realize all two-input Boolean functions. We also build a programmable three-input logic gate by using one PTTG. Compared with linear threshold logic gates, with the PTTG one can build digital circuits more compactly. The proposed PTTGs are promising for future smart nanoscale digital system use.

Peace at last.

Es por la noche y toda la familia Bean se va a la cama pero el señor Bean no puede dormir y la señora Bean empieza a roncar, entonces decide ir a la habitación de su hijo pero éste esta jugando a ser un avión. Se baja a la cocina, sale al jardín, se sube al coche pero tampoco concilia el sueño. Cuando regresa a su cama suena el despertador.

The silly elephant.

Mumbo es un elefante del zoológico y su cuidador es Mr. Moon. Éste le ofrece una manzana pero Mumbo no la quiere, él prefiere las bananas guardadas en una caja grande. Cuando se dispone a abrirla, la caja cae encima del cuidador.

Die Tochter Tehuan's oder Texas im vorigen Jahrhundert

von P. Alto S. Hörmann, O.S.B. Missionär in Amerika