Associação de níveis plasmáticos de PAI-1 e polimorfismo 4G/5G em pacientes com doença arterial coronariana

FUNDAMENTO: O polimorfismo 4G/5G do inibidor ativador do plasminogênio tipo 1 (PAI-1) pode influenciar a expressão do PAI-1. Níveis plasmáticos elevados de PAI-1 estão associados com Doença Arterial Coronariana (DAC). OBJETIVO: O presente estudo investigou a influência do polimorfismo 4G/5G do PAI-1 nos níveis plasmáticos de PAI-1 e sua associação com DAC avaliada por angiografia coronária. MÉTODOS: Foi avaliada amostra de sangue de 35 indivíduos com artérias coronárias angiograficamente normais, 31 indivíduos apresentando ateromatose leve/moderada, 57 indivíduos apresentando ateromatose grave e 38 indivíduos saudáveis (controles). Em pacientes e controles, o polimorfismo 4G/5G do PAI-1 foi determinado por amplificação da proteína-C reativa utilizando primers específicos de alelo. Os níveis plasmáticos de PAI-1 foram quantificados pelo ensaio ELISA (American Diagnostica). RESULTADOS: Não houve diferença entre os grupos quanto a sexo, idade e índice de massa corporal. Níveis plasmáticos de PAI-1 e frequência do genótipo 4G/4G mostravam-se significativamente maiores no grupo com ateromatose grave em comparação com os outros grupos (p < 0,001). Além disso, os pacientes com genótipo 4G/4G (r = 0,28, p < 0,001) apresentaram níveis plasmáticos de PAI-1 significativamente maiores do que aqueles com o genótipo 5G/5G (r = 0,02, p = 0,4511). Além disso, em um modelo de regressão logística múltipla, ajustado para todas as outras variáveis, o PAI-1 esteve independentemente associado com DAC > 70% (p < 0,001). CONCLUSÃO: O achado mais importante deste estudo foi a associação entre o genótipo 4G/4G, elevados níveis plasmáticos de PAI-1 e estenose coronariana superior a 70% em indivíduos brasileiros. Ainda não foi estabelecido se elevados níveis plasmáticos de PAI-1 são um fator decisivo para o agravamento da aterosclerose ou se são uma consequência.

Plasminogen activator inhibitor-1 activity and 4G/5G polymorphism in hemodialysis

Introduction: Chronic insufficiency alters homeostasis, in part due to endothelial inflammation. Plasminogen activator inhibitor-1 (PAI-1) is increased in renal disease, contributing to vascular damage. We assessed PAI-1 activity and PAI-1 4G/5G polymorphism in hemodialysis (HD) subjects and any association between thrombotic vascular access (VA) events and PAI-1 polymorphism. Methods: Prospective, observational study in 36 HD patients: mean age: 66.6 +/- 12.5 yr, males n=26 (72%), time on HD: 28.71 +/- 22.45 months. Vascular accesses: 10 polytetrafluoroethylene grafts (PTFEG), 22 arteriovenous fistulae (AVF), four dual lumen catheters (CAT). Control group (CG): 40 subjects; mean age: 60.0 +/- 15 yrs, males n=30 (75%). Group A (GA): thrombotic events (n=12), and group B (GB): No events (n=24). Groups were no different according to age (69.2 +/- 9.12 vs. 65.3 +/- 14.5 yrs), gender (males: 7; 58.3% vs. 18; 81.8%), time on HD (26.1 +/- 14.7 vs. 30.1 +/- 38.7 months), causes of renal failure. Time to follow-up, for access thrombosis: 12 months. Results: PAI-1 levels in HD: 7.21 +/- 2.13 vs. CG: 0.42 +/- 0.27 U/ml (p < 0.000 1). PAI-1 4G/5G polymorphic variant distribution in HD: 5G/5G: 6 (17%),4G/5G: 23 (64%); 4G/4G: 7 (19%) and in CG: 5G/5G: 14 (35%); 4G/5G: 18 (45%); 4G/4G: 8 (20%). C-reactive protein (CRP) in HD: 24.5 +/- 15.2 mg/L vs. in CG 2.3 +/- 0.2 mg/L (p < 0.0001). PAI-1 4G/5G variants: GA: 5G/5G: 3; 4G/5G: 8; 4G/4G: 1; GB: 5G/5G: 3; 4G/5G: 15; 4G/4G: 6. Thrombosis occurred in 8/10 patients (80%) with PTFEG, 3/22 (9%) in AVF, and 1/4 (25%) in CAT. Among the eight PTFEG patients with thrombosis, seven were PAI 4G/5G. Conclusions: PAI-1 levels were elevated in HD patients, independent of their polymorphic variants, 4G/5G being the most prevalent variant. Our data suggest that in patients with PTFEG the 4G/5G variant might be associated with an increased thrombosis risk.

Um estudo do aumento da capacidade de sistemas 3g WCDMA usando técnicas 3.5G de expansão do enlace reverso

The introduction of new digital services in the cellular networks, in transmission rates each time more raised, has stimulated recent research that comes studying ways to increase the data communication capacity and to reduce the delays in forward and reverse links of third generation WCDMA systems. These studies have resulted in new standards, known as 3.5G, published by 3GPP group, for the evolution of the third generation of the cellular systems. In this Masters Thesis the performance of a 3G WCDMA system, with diverse base stations and thousand of users is developed with assists of the planning tool NPSW. Moreover the performance of the 3.5G techniques hybrid automatic retransmission and multi-user detection with interference cancellation, candidates for enhance the WCDMA uplink capacity, is verified by means of computational simulations in Matlab of the increase of the data communication capacity and the reduction of the delays in the retransmission of packages of information

5g mobile communications systems

Un sistema mobile di comunicazione è un sistema di telecomunicazioni in cui è possibile mantenere la connessione o legame tra due o più utenti, anche nelle situazioni di mobilità totale o parziale degli stessi utenti. I sistemi radiomobili si stanno evolvendo dalla creazione del 1G (prima generazione) al 4G (quarta generazione). I telefoni di ogni generazione si differenziano in quattro aspetti principali : accesso radio, velocità di trasmissione dati, larghezza di banda e sistemi di commutazione. In questa tesi si affronta il tema dei sistemi 5G , negli ambienti terrestri e satellitari , in quanto sono l'ultima evoluzione dei sistemi mobili . Si introduce il passaggio dalla prima alla connessione di quarta generazione , al fine di capire perché 5G sta per cambiare la nostra vita . Quello che mi colpisce è il sito italiano www.Repubblica.it che dice : " con la nuova generazione 5 possiamo affidare le intere porzioni nette di vita". La tecnologia cellulare , infatti , ha cambiato radicalmente la nostra società e il nostro modo di comunicare . In primo luogo è cambiata la telefonia vocale , per poi trasferirsi all' accesso dati , applicazioni e servizi. Tuttavia , Internet non è stato ancora pienamente sfruttato dai sistemi cellulari. Con l'avvento del 5G avremo l'opportunità di scavalcare le capacità attuali di Internet . Il sistema di comunicazione di quinta generazione è visto come la rete wireless reale , in grado di supportare applicazioni web wireless a livello mondiale ( wwww ). Ci sono due punti di vista dei sistemi 5G : evolutivo e rivoluzionario. Dal punto di vista evolutivo, i sistemi 5G saranno in grado di supportare wwww permettendo una rete altamente flessibile come un Adhoc rete wireless dinamica ( DAWN ) . In questa visione tecnologie avanzate, tra cui antenna intelligente e modulazione flessibile , sono le chiavi per ottimizzare le reti wireless ad hoc. Dal punto di vista rivoluzionario, i sistemi 5G dovrebbe essere una tecnologia intelligente in grado di interconnettere tutto il mondo senza limiti . Un esempio di applicazione potrebbe essere un robot wireless con intelligenza artificiale .

L'evoluzione dei sistemi wireless verso il 5g

Sintetizzare le caratteristiche dei sistemi wireless fino al 4G ed evidenziare le innovazioni che verranno introdotte dai sistemi 5G

Network Store: Exploring Slicing in Future 5G Networks

In this paper, we present a revolutionary vision of 5G networks, in which SDN programs wireless network functions, and where Mobile Network Operators (MNO), Enterprises, and Over-The-Top (OTT) third parties are provided with NFV-ready Network Store. The proposed Network Store serves as a digital distribution platform of programmable Virtualized Network Functions (VNFs) that enable 5G application use-cases. Currently existing application stores, such as Apple's App Store for iOS applications, Google's Play Store for Android, or Ubuntu's Software Center, deliver applications to user specific software platforms. Our vision is to provide a digital marketplace, gathering 5G enabling Network Applications and Network Functions, written to run on top of commodity cloud infrastructures, connected to remote radio heads (RRH). The 5G Network Store will be the same to the cloud as the application store is currently to a software platform.

Estudio de modelos de propagación en bandas milimétricas para su futura utilización en redes de comunicaciones móviles 5G

La generalización del uso de dispositivos móviles, con su consiguiente aumento del tráfico de datos, está generando una demanda cada vez mayor de bandas de frecuencia para el despliegue de sistemas de comunicación inalámbrica, así como una creciente congestión en las bandas bajas del espectro (hasta 3 GHz). Entre las posibles soluciones a este problema, se ha propuesto que la próxima generación de sistemas celulares, 5G, hagan uso de la banda milimétrica, entre 30 GHz y 300 GHz, donde hay anchos de banda contiguos disponibles con tamaños muy difíciles de encontrar en las frecuencias en uso en la generación actual. Este Proyecto de Fin de Grado tiene como finalidad estudiar la viabilidad del despliegue de sistemas celulares en dicha banda, basándose en los estudios tanto empíricos como teóricos ya publicados, así como en las recomendaciones de la UIT donde se estudian las características de propagación en estas bandas. En un siguiente apartado, se han analizado los documentos disponibles de los distintos proyectos y grupos, como pueden ser METIS-2020, impulsado por la Comisión Europea o IMT-2020 promovido por la UIT, dedicados a definir los futuros estándares de comunicación y sus características, así como la evolución de los actuales. Aparte del trabajo de documentación, se han realizado una serie de simulaciones. En primer lugar, se ha utilizado MATLAB para estudiar el comportamiento y la atenuación de la onda electromagnética a las frecuencias de interés en diferentes ubicaciones y climas, tanto en ubicaciones habituales como extremas, estudiándose los efectos de los gases atmosféricos y los hidrometeoros. También se ha utilizado software de planificación radioeléctrica profesional para hacer estudios de cobertura en entornos tanto urbanos, entre ellos Madrid o Barcelona, suburbanos, como Tres Cantos (Madrid) y O Barco de Valdeorras (Orense), y rurales como Valdefuentes (Cáceres) y Quiruelas de Vidriales (Zamora). Por último se han recogido todos los resultados, tanto los provenientes de los estudios como los obtenidos de nuestras propias simulaciones, y se ha realizado un breve comentario, comparando estos y analizando su impacto para posibles despliegues futuros de redes 5G. ABSTRACT. The generalization of mobile device use, with its associated data traffic growth, is generating a growing demand of spectrum for its use in the deployment of wireless telecommunication systems, and a growing congestion in the lower end of the spectrum (until 3 GHz). Among the possible solutions for this problem, it has been proposed that the next generation of cellular systems, 5G, makes use of the millimeter band, between 30 GHz and 300 GHz, where there are contiguous bandwidths with sizes hardly available in the bands used in the present. This Project aims to study the feasibility of cellular system deployments in said band, based on published empirical and theoretical studies and papers, and the ITU recommendations, where the propagation characteristics in those bands are studied. In the next section, available documentation coming from the different study groups and projects like METIS 2020 promoted by the European Commission, or IMT-2020, promoted by the ITU has been studied. In the documentation, future telecommunication standards and its characteristics and the evolution of the current ones are defined. Besides the documentation work, a series of simulations have been carried out. First, MATLAB has been used to study the behavior and attenuation of the electromagnetic wave at the frequencies of interest in different locations and climates, studying the effects of atmospheric gasses and hydrometeors in conventional and extreme locations. Industry standard radioelectric planning software has been used to study the coverage in different environments, such as urban locations like Madrid and Barcelona, both in Spain, suburban locations like Tres Cantos (Madrid, Spain) and O Barco de Valdeorras (Orense, Spain) and rural locations such as Valdefuentes (Cáreces, Spain) and Quiruelas de Vidriales (Zamora, Spain). Finally, all the results, both from the documentation and our own simulations, have been collected, and a brief commentary has been made, comparing those results and their possible impact in the future deployment of 5G networks.

Comunicazioni basate su onde millimetriche per sistemi 5G

Le comunicazioni wireless di Quinta Generazione, le quali è assodato che vadano a ricoprire un ruolo chiave e centrale nel futuro delle comunicazioni mobili, hanno suscitato l’interesse e l’investigazione da parte delle maggiori organizzazioni ed enti di ricerca internazionali. Internet of Things, i cosiddetti Use Cases, gli indici KPI e le tecnologie candidate per lo sviluppo, sono tra gli altri, i maggiori aspetti su cui attualmente la ricerca pone la propria attenzione al fine di poter definire ed implementare la rete di Quinta Generazione. Non da meno, ricevono forte interesse anche una serie d’aspetti legati all’utilizzo delle elevate frequenze, in particolar modo le bande delle onde millimetriche, nello sviluppo delle comunicazioni per sistemi 5G. L’utilizzo delle onde millimetriche nel futuro delle comunicazioni mobili è ad oggi considerato il fulcro della ricerca per l’implementazione dell’ architettura di rete di Quinta Generazione. Lo sviluppo di comunicazioni basate sulle onde millimetriche per i sistemi 5G presentano sia delle opportunità ma anche importanti problematiche. Tra queste ultime, l’elevate attenuazioni registrate nelle bande delle onde millimetriche pongono severi limiti qualora si voglia stabilire una comunicazione a lungo raggio e tale è un aspetto critico che interesse fortemente i vari ambiti della ricerca per poter efficacemente porre le basi per il futuro della comunicazione mobile di Quinta Generazione.

Operator's, organizational, direct support, and general support maintenance manual : refrigeration unit, mechanical, panel type, 5000 Btu/hr, gasoline engine driven (GED), model ERU-5G (NSN 4110-01-076-1991).

"1 May 1981."

Secure 5G Wireless Communications: A Joint Relay Selection and Wireless Power Transfer Approach

In this paper, we investigate the secrecy performance of an energy harvesting relay system, where a legitimate source communicates with a legitimate destination via the assistance of multiple trusted relays. In the considered system, the source and relays deploy the time-switching-based radio frequency energy harvesting technique to harvest energy from a multi-antenna beacon. Different antenna selection and relay selection schemes are applied to enhance the security of the system. Specifically, two relay selection schemes based on the partial and full knowledge of channel state information, i.e., optimal relay selection and partial relay selection, and two antenna selection schemes for harvesting energy at source and relays, i.e., maximizing energy harvesting channel for the source and maximizing energy harvesting channel for the selected relay, are proposed. The exact and asymptotic expressions of secrecy outage probability in these schemes are derived. We demonstrate that applying relay selection approaches in the considered energy harvesting system can enhance the security performance. In particular, optimal relay selection scheme outperforms partial relay selection scheme and achieves full secrecy diversity order, regardless of energy harvesting scenarios.

5G innovation opportunities-- A discussion paper

On the shaping of 5G technologies and networks, scope for wider service and applications innovation and UK strengths and opportunities.

Introducing mobile edge computing capabilities through distributed 5G Cloud Enabled Small Cells

Current trends in broadband mobile networks are addressed towards the placement of different capabilities at the edge of the mobile network in a centralised way. On one hand, the split of the eNB between baseband processing units and remote radio headers makes it possible to process some of the protocols in centralised premises, likely with virtualised resources. On the other hand, mobile edge computing makes use of processing and storage capabilities close to the air interface in order to deploy optimised services with minimum delay. The confluence of both trends is a hot topic in the definition of future 5G networks. The full centralisation of both technologies in cloud data centres imposes stringent requirements to the fronthaul connections in terms of throughput and latency. Therefore, all those cells with limited network access would not be able to offer these types of services. This paper proposes a solution for these cases, based on the placement of processing and storage capabilities close to the remote units, which is especially well suited for the deployment of clusters of small cells. The proposed cloud-enabled small cells include a highly efficient microserver with a limited set of virtualised resources offered to the cluster of small cells. As a result, a light data centre is created and commonly used for deploying centralised eNB and mobile edge computing functionalities. The paper covers the proposed architecture, with special focus on the integration of both aspects, and possible scenarios of application.

Enabling 5G and beyond: millimeter wave propagation and cloud RAN evolution

In the last few years, mobile wireless technology has gone through a revolutionary change. Web-enabled devices have evolved into essential tools for communication, information, and entertainment. The fifth generation (5G) of mobile communication networks is envisioned to be a key enabler of the next upcoming wireless revolution. Millimeter wave (mmWave) spectrum and the evolution of Cloud Radio Access Networks (C-RANs) are two of the main technological innovations of 5G wireless systems and beyond. Because of the current spectrum-shortage condition, mmWaves have been proposed for the next generation systems, providing larger bandwidths and higher data rates. Consequently, new radio channel models are being developed. Recently, deterministic ray-based models such as Ray-Tracing (RT) are getting more attractive thanks to their frequency-agility and reliable predictions. A modern RT software has been calibrated and used to analyze the mmWave channel. Knowledge of the electromagnetic properties of materials is therefore essential. Hence, an item-level electromagnetic characterization of common construction materials has been successfully achieved to obtain information about their complex relative permittivity. A complete tuning of the RT tool has been performed against indoor and outdoor measurement campaigns at 27 and 38 GHz, setting the basis for the future development of advanced beamforming techniques which rely on deterministic propagation models (as RT). C-RAN is a novel mobile network architecture which can address a number of challenges that network operators are facing in order to meet the continuous customers’ demands. C-RANs have already been adopted in advanced 4G deployments; however, there are still some issues to deal with, especially considering the bandwidth requirements set by the forthcoming 5G systems. Open RAN specifications have been proposed to overcome the new 5G challenges set on C-RAN architectures, including synchronization aspects. In this work it is described an FPGA implementation of the Synchronization Plane for an O-RAN-compliant radio system.