989 resultados para 516


Relevância:

20.00% 20.00%

Publicador:

Resumo:

Os constituintes aprovam uma fusão de emendas que permite a União instituir empréstimos compulsórios, que depende da aprovação do Congresso Nacional. A divergência na discussão da emenda foi quanto ao quorum necessário. Prevaleceu o quorum de maioria absoluta dos membros Congresso Nacional para aprovação dos empréstimos a serem criados pela União para atender despesas extraordinárias em caso de calamidade pública ou de guerra. Os constituintes consideram que os municípios ganham com a Reforma Tributária da nova Carta. A Constituinte discute a anualidade da cobrança de impostos. O imposto criado ou aumentado em um ano será cobrado no ano seguinte.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

A small stream in the French Alps was sampled at regular intervals to determine the size distribution of animals for growth studies. The temperature was also measured. The results obtained for Gammarus fossarum were compared with laboratory cultures and the laboratory animals were physiologically and chemically analysed. Chemical analysis was also carried out on field animals.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

The 70kDa ribosomal protein S6 kinase 1 (S6K1) plays important roles in the regulation of protein synthesis, cell growth and metabolism. S6K1 is activated by the phosphorylation of multiple serine and threonine residues in response to stimulation by a variety of growth factors and cytokines. In addition to phosphorylation, we have recently shown that S6K1 is also targeted by lysine acetylation. Here, using tandem mass spectrometry we have mapped acetylation of S6K1 to lysine 516, a site close to the C-terminus of the kinase that is highly conserved amongst vertebrate S6K1 orthologues. Using acetyl-specific K516 antibodies, we show that acetylation of endogenous S6K1 at this site is potently induced upon growth factor stimulation. Although S6K1 acetylation and phosphorylation are both induced by growth factor stimulation, these events appear to be functionally independent. Indeed, experiments using inhibitors of S6K1 activation and exposure of cells to various stresses indicate that S6K1 acetylation can occur in the absence of phosphorylation and vice versa. We propose that K516 acetylation may serve to modulate important kinase-independent functions of S6K1 in response to growth factor signalling.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Pressure vessels are equipments that require a great care because of their high cost and human life risk in case of fail, and its fabrication methods are different for each manufacturer. Normally, pressure vessels and its parts are fabricated by welding, which may change local properties of metals. The head of a pressure vessel is a very important structural component and it is fabricated by welding and mechanical conformation. Because its excellent mechanical properties, de steel A-516 Grade 70 is often used in manufacturing of large pressure vessels that are subjected to high pressure and temperature, but was verified that its mechanical resistance is decreased when submitted to a tension relief heat treatment. By experience it was defined that before mechanical conformation of the head of a large pressure vessel, the steel should be submitted to a stress relief heat treatment in order to facilitate the mechanical conformation, but there is no quantitative analysis to prove this method and study its possible risks. In the present work the steel A-516 Grade 70 demonstrated a decrease of its mechanical resistance when submitted to a stress relief heat treatment, but keeping above the minimum limit defined in the literature. By other side its ductility was substantially increased, being possible to deduce that the stress relief heat treatment before mechanical conformation is a viable e recommended technique, but with reservations. With the data acquired during the fabrication e preparation of the specimen and the result of the tests, it was possible to elaborate a welding procedure that provides the same results obtained in this present work

Relevância:

20.00% 20.00%

Publicador:

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Vorlage des Digitalisats: Theologische Zentralbibliothek in der UB Frankfurt