Recycled Portland Cement Concrete Pavement in Iowa, HR-506, 1984

In recent years, there has been an increased interest in conservation of our resources, preservation of our environment and maintaining our ecology. Recycling of materials is a procedure that will immediately contribute to all of these desirable end results. Our economy is built on private enterprise and profit incentive and in the past, with abundant inexpensive resources, there was little incentive to recycle. Shortages of materials and energy (once considered abundant) along with regulations to protect the environment have emphasized the need for recycling. These environmental conditions coupled with the loss of purchase power by inflation has generated more interest in recycling in the transportation field. The Iowa Department of Transportation (Iowa DOT) is interested in recycling portland cement concrete (pcc) pavement to: 1. Provide aggregate where high quality aggregate is no longer economically available. 2. Eliminate the need for locations to waste the large amount of pavement rubble. 3. Conserve the present aggregate sources. 4. Reduce the need for disrupting land for quarrying purposes. 5. Save fuel and energy by reducing aggregate transportation.

Exposição de fibroblastos provenientes de pterígios recidivados e da cápsula de Tenon normal ao tacrolimus (FK-506)

OBJETIVO: Avaliar a taxa de proliferação de fibroblastos provenientes de pterígios recidivados e da cápsula de Tenon normal, quando expostos in vitro ao tacrolimus (FK 506). MÉTODOS: Foi realizado estudo prospectivo, controlado, avaliando-se 8 amostras de explantes de cápsula de Tenon de pterígios recidivados e 6 de cápsula de Tenon normal, obtidas na Faculdade de Medicina de Botucatu - UNESP. A cápsula de Tenon normal foi colhida da região temporal inferior, do mesmo portador de pterígio. As amostras foram cultivadas em meio específico e posteriormente expostas ao tacrolimus 1M (FK 506), em única exposição, com avaliação da taxa de proliferação celular 1, 5, 12 e 19 dias após a exposição. RESULTADOS: Avaliando-se a proliferação dos fibroblastos provenientes de cápsula de Tenon de pterígios recidivados e da cápsula de Tenon normal, os fibroblastos expostos ao tacrolimus tiveram taxa de proliferação significativamente menor (p<0,05) do que quando não houve exposição a droga, quando a avaliação foi feita 1 dia após a exposição. Quando a avaliação foi feita 19 dias após a exposição, a taxa de proliferação foi maior nos grupos expostos a droga. CONCLUSÃO: Os fibroblastos provenientes da cápsula de Tenon de pterígios recidivados apresentaram taxa de proliferação significativamente menor um dia após a exposição ao tacrolimus. Novos estudos devem ser realizados para definir dose e tempo de exposição dos fibroblastos a droga, com o intuito de definir se o tacrolimus pode ser útil como tratamento coadjuvante do pterígio.

Effects of Long-Term FK 506 Therapy on the Alveolar Bone and Cementum of Rats

Cyclosporine (CsA) and tacrolimus (FK 506) exert complex, incompletely understood actions on bone. The objective of the study was to evaluate the effects of long-term tacrolimus therapy on the periodontium. Rats were treated for 60, 120, 180, and 240 days with daily subcutaneous injections of 1 mg/kg body weight of FK 506. After the experimental period, we obtained serum levels of calcium and alkaline phosphatase (ALP). After histological processing, the alveolar bone and cementum, as well as volume densities of bone (Vb) and osteoclasts (Vo), were assessed at the regions of the lower first molar. There was a tendency toward a statistically significant decrease in ALP levels with FK 506; however, serum calcium levels increased during the long periods. At 60, 180, and 240 days of treatment with FK 506, we did not observe Vb and Vo alterations. At 120 days of treatment, there was an evident decrease in Vb, but it did not show alveolar bone loss. We did not observe any alterations of cementum among rats treated with FK 506. It may be concluded that FK 506 administration did not induce side effects on the periodontium. © 2009 Elsevier Inc. All rights reserved.

Influência do FK-506 sobre a expressão de RANKL e OPG na doença periodontal induzida: estudo in vivo e in vitro

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Efeitos do FK-506 na regeneração de nervos após neurorrafia láteo-terminal: estudo em ratos

Pós-graduação em Bases Gerais da Cirurgia - FMB

Zu Ginse Schechter [Nachricht] : (s. o. S. 506)

Louis Ginzberg

Zu Ginse Schechter : (s. o. S. 506)

Bernhard Heller

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 506 - Bitte an Johann Friedrich Blumenbach um Einschätzung des Habilitationsvorhabens

u.a.: Ankündigung der Habilitation; Bevorzugung von Göttingen als Studienort;

Na 1 Nachlass Max Horkheimer, 506 - Korrespondenzen mit Theodor W. Adorno (p. VI 1D, 1 - 229)

69 Briefe zwischen Theodor W. Adorno, Gretel Adorno und Max Horkheimer mit Beilagen, 1949-1950; 1 Brief von Gretel Adorno an Margot von Mendelssohn, 15.08.1950; 1 Brief von Max Horkheimer an Alice Maier, 08.05.1950; 1 Brief von Max Bense an Max Horkheimer, 20.12.1949; 5 Briefe zwischen Theodor W. Adorno und Hans Paeschke, 1949; 2 Briefe zwischen Theodor W. Adorno und Melvin J. Lasky, 1949; 1 Brief von Max Horkheimer an John Slawson; 1 Brief von Max Horkheimer an Sandy Flowerman, 1949; 1 Brief von Friedrich Pollock an Max Horkheimer, 12.10.1949; 1 Brief von Maria W. an Max Horkheimer, 03.10.1949; 2 Briefe zwischen Marc Vosk und Theodor W. Adorno, 1949; 1 Brief von Marc Vosk, 26.05.1949;

Ms.Ff.F.Stoltze 3. 506 - Brief von Friedrich Stoltze an Marie Stoltze

Friedrich Stoltze II, Marie Stoltze, Familie

Inc. oct. 506 - [Sammelband in 4 Teilen: Konvolut aus Inkunabeln]

Vorbesitzer: Leonhardstift Frankfurt am Main