Towards beneficence for young children in research : challenges for bioethics committees

Bioethics committees are the focus of international scrutiny,particularly in relation to their application of the principle of beneficence,ensuring that risks incurred in research are outweighed by benefits to those involved directly and to the broader society. Beneficence, in turn, has become an international focus in research with young children, who hitherto had been rarely seen or heard in their own right in research.Twenty years ago, The United Nations Convention on the Rights of the Child 1989 raised global awareness of children’s human rights to both participation and protection, and articulation of children’s rights came to inform understandings of young children’s rights in research. In the intervening period, countries such as Australia came to favour child protection and risk minimisation in research over the notion of children’s bone fide participation in research. A key element of the protection regime was the theoretical understanding of young children as developmentally unable and, therefore, unfit to understand, consent to and fully participate as research participants. This understanding has been challenged in recent decades by new theoretical understandings of children’s competence, where children can be seen to demonstrate competence, even at an early age, in consenting to, participating in and withdrawing from research. The paper draws on these understandings to provide insights for human research gatekeepers, such as bioethics committees, to deal with the challenges of research with young children and to realize the benefits that may accrue to children in research.

Management of the rhesus monkey Macaca mulatta and hanuman langur Presbytis entellus in Himachal Pradesh, India

The rhesus monkey Macaca mulatta and Hanuman langur Presbytis entellus are distributed all over the State of Himachal Pradesh, India. Although both species inhabit forested areas, only rhesus monkeys seem also to have become urbanized. There are about 200,000 rhesus monkeys and 120,000 Hanuman langurs. A three-year survey at Shimla showed an increasing trend in their populations. Potential threats to survival of these primates differ in the 12 districts. The two species differ in feeding and habitat preferences. People's feelings, perceptions and attitudes reward them point to an incipient man-monkey conflict and erosion of conservation ethics. A comprehensive management plan for these primates should be formulated, and involve local people. Copyright (C) 1996 Elsevier Science Limited

幂硬化材料Ⅲ型稳恒扩展裂纹奇异场

幂硬化材料稳恒扩展裂纹奇异场的分析是久未解决的困难问题。本文对Ⅲ型问题得到了含有对数奇异性的解,给出了尖端附近应力与应变的奇异场的可能变化范围。

Un robot al servicio de la fantasía.

Se presenta la experiencia puesta en marcha en el Colegio Público 'La Fuenfresca' de Teruel durante el curso 1999-2000. Se trata de escribir un cuento durante todo el año que tiene como protagonista a un personaje creado por los propios niños, el robot Fresquín. Los alumnos y alumnas traen noticias de los medios de comunicación a clase y elaboran las historias y peripecias por las que va a ir pasando el robot. Los objetivos perseguidos en esta experiencia son, entre otros, despertar la afición por la lectura y la escritura, desarrollar la imaginación y la creatividad, compartir sus ideas con los demás y apoyarse en la prensa para elaborar historias propias. La propuesta educativa tiene carácter multidisciplinar e intervienen diversas áreas o materias: lenguaje, educación artística y matemáticas.

Ferroelectric properties and leakage current characteristics of Bi3.25La0.75Ti3O12 thin films prepared by the polymeric precursor method

The ferroelectric properties and leakage current mechanisms of preferred oriented Bi3.25La0.75Ti3O12 (BLT) thin films deposited on La0.5Sr0.5CoO3 by the polymeric precursor method were investigated. These films showed excellent ferroelectric properties in terms of large remnant polarization (2P(r)) of 47.6 mu C/cm(2) and (2E(c)) of 55 kV/cm, fatigue-free characteristics up to 10(10) switching cycles, and a current density of 0.7 mu A/cm(2) at 10 kV/cm. X-ray diffraction and scanning electron microscope investigations indicate that the deposited films exhibit a dense, well-crystallized microstructure having random orientations and with a rather smooth surface morphology. The improved ferroelectric and leakage current characteristics can be ascribed to the platelike grains of the BLT films, which make the domain walls easier to be switched under external field.

Training Report #1- Report on Training Programme Conducted October 2013 in Guyana

This project, "Sustainable Energy in the Caribbean", implemented by the United Nations Economic Commission for Latin America and the Caribbean (UN-ECLAC) will support the following: - Technical assistance to three countries of the Caribbean in the evaluation of existing fiscal systems and regulations as they relate to energy efficiency and renewable energy technologies so as to identify gaps and barriers to implement these technologies and to provide options for their removal  Development of national documents on strengthening fiscal and regulatory systems for at six countries – Guyana, Curacao, Belize, Grenada, Saint Lucia and Antigua & Barbuda. - Provision of technical assistance in proposing innovative fiscal and regulatory incentives to promote energy efficiency and renewable energy initiatives in three countries - Development of a training manual on innovative fiscal and regulatory incentives for energy efficiency and renewable energy initiatives - Implementation of capacity building workshops on best practices to improve the fiscal and management environment with a view to support the employment of EE and RE initiatives - Development of three national (Aruba, The Bahamas and Suriname) energy policies that incorporate strategies for energy efficiency and the employment of renewable energy technologies. These may be used as examples for other Caribbean countries

A defective SERCA1 protein is responsible for congenital pseudomyotonia in Chianina cattle

Recently, a muscular disorder defined as "congenital pseudomyotonia" was described in Chianina cattle, one of the most important Italian cattle breeds for quality meat and leather. The clinical phenotype of this disease is characterized by an exercise-induced muscle contracture that prevents animals from performing muscular activities. On the basis of clinical symptoms, Chianina pseudomyotonia appeared related to human Brody's disease, a rare inherited disorder of skeletal muscle function that results from a sarcoplasmic reticulum Ca(2+)-ATPase (SERCA1) deficiency caused by a defect in the ATP2A1 gene that encodes SERCA1. SERCA1 is involved in transporting calcium from the cytosol to the lumen of the sarcoplasmic reticulum. Recently, we identified the genetic defect underlying Chianina cattle pseudomyotonia. A missense mutation in exon 6 of the ATP2A1 gene, leading to an R164H substitution in the SERCA1 protein, was found. In this study, we provide biochemical evidence for a selective deficiency in SERCA1 protein levels in sarcoplasmic reticulum membranes from affected muscles, although mRNA levels are unaffected. The reduction of SERCA1 levels accounts for the reduced Ca(2+)-ATPase activity without any significant change in Ca(2+)-dependency. The loss of SERCA1 is not compensated for by the expression of the SERCA2 isoform. We believe that Chianina cattle pseudomyotonia might, therefore, be the true counterpart of human Brody's disease, and that bovine species might be used as a suitable animal model.

Efficient PGD-based dynamic calculation of non-linear soil behavior

Non-linear behavior of soils during a seismic event has a predominant role in current site response analysis. Soil response analysis consistently indicates that the stress-strain relationship of soils is nonlinear and shows hysteresis. When focusing in forced response simulations, time integrations based on modal analysis are widely considered, however parametric analysis, non-linear behavior and complex damping functions make difficult the online use of standard discretization strategies, e.g. those based on the use of finite element. In this paper we propose a new harmonic analysis formulation, able to address forced response simulation of soils exhibiting their characteristic nonlinear behavior. The solution can be evaluated in real-time from the offline construction of a parametric solution of the associated linearized problem within the Proper Generalized Decomposition framework.

El Diccionario funcionalista como instrumento de aprendizaje de una Lengua: experiencias previas a la digitalización

Este documento presenta los resultados de una primera investigación sobre el uso de un modelo de diccionario latino-castellano de corte funcionalista acompañado por una metodología docente adecuada para mejorar los resultados académicos de los estudiantes de la lengua Latina. Para evaluar esta hipótesis se ha diseñado y llevado a cabo un caso de estudio con alumnos de Educación Secundaria, con edades comprendidas entre los quince y los dieciséis años, que cursan la asignatura de Latín. El objetivo concreto era demostrar si el uso único del diccionario propuesto constituye una herramienta de apoyo suficiente en las labores de análisis lingüístico y traducción de textos latinos adaptados a su nivel, de manera que el alumno prescinda, en la medida de lo posible del uso de cualquier otro material gramatical complementario. Los resultados obtenidos sugieren que el cambio de metodología ha incidido positivamente en el proceso cognitivo del alumno puesto que se observó un incremento significativo en la motivación y en las calificaciones obtenidas en las pruebas de evaluación respecto al grupo de control y con respecto a la actitud y a las evaluaciones iniciales del grupo de actuación. Los resultados, por lo tanto, motivan la creación de una versión digital en línea que permitirá al alumno usarla tanto el aula como en el trabajo personal.