Genetic influences on brain asymmetry: A DTI study of 374 twins and siblings

Brain asymmetry, or the structural and functional specialization of each brain hemisphere, has fascinated neuroscientists for over a century. Even so, genetic and environmental factors that influence brain asymmetry are largely unknown. Diffusion tensor imaging (DTI) now allows asymmetry to be studied at a microscopic scale by examining differences in fiber characteristics across hemispheres rather than differences in structure shapes and volumes. Here we analyzed 4. Tesla DTI scans from 374 healthy adults, including 60 monozygotic twin pairs, 45 same-sex dizygotic pairs, and 164 mixed-sex DZ twins and their siblings; mean age: 24.4 years ± 1.9 SD). All DTI scans were nonlinearly aligned to a geometrically-symmetric, population-based image template. We computed voxel-wise maps of significant asymmetries (left/right differences) for common diffusion measures that reflect fiber integrity (fractional and geodesic anisotropy; FA, GA and mean diffusivity, MD). In quantitative genetic models computed from all same-sex twin pairs (N=210 subjects), genetic factors accounted for 33% of the variance in asymmetry for the inferior fronto-occipital fasciculus, 37% for the anterior thalamic radiation, and 20% for the forceps major and uncinate fasciculus (all L > R). Shared environmental factors accounted for around 15% of the variance in asymmetry for the cortico-spinal tract (R > L) and about 10% for the forceps minor (L > R). Sex differences in asymmetry (men > women) were significant, and were greatest in regions with prominent FA asymmetries. These maps identify heritable DTI-derived features, and may empower genome-wide searches for genetic polymorphisms that influence brain asymmetry.

Diário da Constituinte [gravação de vídeo] : [programa n. 374]

A hora é de rever artigo por artigo, analisar emenda por emenda e finalmente votar o voto definitivo que vai marcar o futuro do Brasil. O Regimento será resolvido em janeiro e até abril os temas polêmicos serão decididos no voto. Fechar a transição e garantir para o país regras de funcionamento estáveis, duradouras, destinadas a vencer crises e atravessar décadas. Esta é a tarefa de cada um dos constituintes. Os constituintes esperam chegar ao entendimento eliminando as confrontações. Terminada a Constituição, cabe o preparo das leis complementares, adaptar as constituições estaduais, dar atenção aos problemas da Câmara e do Senado e cuidar da reformulação política e partidária que a nova Carta trará.

C 193 INST-D 2013. 374 Procesos de lavado, tinturado secado y escarmenado de lana virgen.

12 fotografías a color.

Les diplômés – no 374, été 1991

Pour toute demande de reproduction de contenu se trouvant dans cette publication, communiquer avec l’Association des diplômés de l’UdeM.

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 374 - Schreiben von Ottilie von Goethe an Emilie von Meyer-Neuschenbach zwecks Bekanntmachung mit Johanna und Adele Schopenhauer

u.a.: Verhältnis zu Arthur Schopenhauer; Ottilie Goethe; Adele Schopenhauer;

Ms.Ff.F.Stoltze 3. 374 - Brief von Friedrich Stoltze an Feodor Körber

Frankfurter Latern, Reklamation zum Druck

Chemical and isotope compositions of interstitial water in sediments from Mediterranean basin at DSDP Sites 42-372 and 42-374

The Br/Cl, Li/Cl and B/Cl ratios and boron isotope compositions of hypersaline pore fluids from DSDP Sites 372 and 374 were measured in an attempt to evaluate the origin of the brines. In Site 374 the relationships between the Cl concentrations (up to 5000 mM) and Br/Cl (~0.012), Na/Cl (as low as 0.1), B/Cl (0.0025), and d11B values (43-55?) of the deep pore water between 380 and 405 mbsf, located within the Messinian sediments, reflect remnants of ~65-fold evaporated sea water. The original evaporated sea water was modified by: (1) dilution with overlying or less saline water by about 30%; and (2) slight dissolution of NaCl evaporites. The variations in d11B show a continuous increase in d11B values with depth in Site 374, up to 66.7? at a depth of 300 mbsf (Upper Pliocene marl sediments). The conspicuous 11B enrichment trend is consistent with elemental boron depletion, which was calculated from the expected boron concentrations of evaporated sea water with corresponding Br/Cl and Na/Cl ratios. Li/Cl variations also show a depletion of Li relative to evaporated sea water. The apparent depletions of B and Li, as well as the 11B enrichment, reflect uptake of these elements by clay minerals at low water/sediment ratios.

James J. Clauss y Sarah Iles Johnston (edd.). Medea. Princeton-New Jersey, Princeton University Press, 1997, xiii + 374 pp.

Fil: Schamun, María Cecilia. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

Hanno Ehrlicher y Nanette Rißler-Pipka (eds.), Almacenes de un tiempo en fuga: revistas culturales en la modernidad hispánica, Berlín: Shaker Verlag, 2014, 374 pp.

Fil: Delgado, Verónica. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.

Anthony J. Bowen, Aeschylus. Suppliant Women. Edited with a Translation, Introduction and Commentary, Aris & Phillips Classical Texts, Oxford, 2013, 374 pp.

Fil: Fernández Deagustini, María del Pilar. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.