992 resultados para 346.048


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La presente obra es fruto del esfuerzo de la investigación sobre la propiedad intelectual en Colombia. Desarrolla el tema de los derechos de autor y la propiedad industrial y reseña los convenios, acuerdos, decisiones, normas y leyes, mediante las cuales Colombia protege y regula la propiedad intelectual. Ha sido desarrollada de manera general, didáctica y amena: para que pueda emplearse como un texto sobre estudio, referencia y guía para adelantar futuras investigaciones sobre el tema. Está dirigida a magistrados, jueces, funcionarios de entidades relacionadas con la propiedad intelectual, estudiantes de Derecho, de posgrado y en general, al público interesado en tener conocimiento sobre el mismo

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Se pretende con este trabajo observar, estudiar y analizar posibles soluciones y opciones para un manejo apropiado del conocimiento tradicional donde se garantice el reconocimiento de los derechos colectivos en el campo de la propiedad intelectual.

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El objetivo de este estudio es analizar las características que tiene el Sistema de Propiedad Industrial, desde el punto de vista de las posibilidades que ofrece para el aprendizaje y desarrollo tecnológico de la empresa colombiana.

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This series of research vignettes is aimed at sharing current and interesting research findings from our team of international Entrepreneurship researchers. This vignette is written by Professor Erkko Autio at Imperial College (UK) with some editing by the Director of ACE, Professor Per Davidsson.

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La lectura “política” de la Biblia / Armando J. Levoratti -- Las opciones misionales en el Chaco del siglo XVII ¿Evangelización o guerra justa? / Ernesto J. A. Maeder -- Dios y el hombre creador. Método teológico para un análisis estructural de “Amadeus”, film de Milos Forman y Peter Shaffer / Fernando Ortega -- Crónica de la semana anual de estudio y reflexión teológica de la Sociedad Argentina de Teología -- Notas bibliográficas -- Libros recibidos -- Crónica de la Facultad -- Índice del Tomo XXIII

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以2000—03到2001—02的辐射观测资料,分析了海北高寒草甸生态系统定位站地区辐射及各分光辐射的变化特征.将为高寒草甸生态系统的物质循环、能量流动、草地生产力形成机制等问题的研究提供科学依据。结果表明:海北站区Eg、Er、UV、PAR、NIR和En具有明显的日、年变化,年内其总量分别达6278.867MJ/m^2、1515.139MJ/m^2、311.242MJ/m^2、2576.777MJ/m^2、3397.404MJ/m^2和2542.950MJ/m^2,其中在植物生长期的5—9月分别为3181.215MJ/m^2、698.021MJ/m^2、165.955MJ/m^2、1133.965MJ/m^2、1673.871MJ/m^2和1668.805MJ/m^2。年内Er、UV、PAR、NIR和Eh占Eg的比例分别为0.242、0.048、0.410、0.540和0.410,在植物生长期分别为0.219、0.052、0.413、0.528和0.527。对Eg和PAR提出了下列形式的模拟求算式.Eg=Eg0(0.089.7+0.9768S/S0)和PAR=-3.8044+0.4177%,模拟效果较好,可利用有关常规气象观测资料进行估算。

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A preliminary search for stars that may have formed coevally with the apparently young halo B-type star PHL 346 has been performed with the 2dF multifibre spectrograph on the Anglo- Australian Telescope (AAT). Candidates were selected for spectroscopy from APM scans of B and R Schmidt plates centred on PHL 346. A total of 476 stars of spectral type A or F were found; radial velocity estimates and more accurate spectral type assignments narrowed the number of possible coeval candidates to 6 A-type and 14 F-type stars. A statistical analysis of these results using a comparison with a control field suggests that the number of A-type or F-type candidate stars around PHL 346 is not unexpected, and that they need not be associated with PHL 346. A number of ways to improve the project are suggested.

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Studies of HeLa cells and serum- and glucocorticoid-regulated kinase 1 (SGK1) knockout mice identified threonine residues in the n-myc downstream-regulated gene 1 protein (NDRG1-Thr(346/356/366)) that are phosphorylated by SGK1 but not by related kinases (Murray et al., Biochem J 385:1-12, 2005). We have, therefore, monitored the phosphorylation of NDRG1-Thr(346/356/366) in order to explore the changes in SGK1 activity associated with the induction and regulation of the glucocorticoid-dependent Na+ conductance (G (Na)) in human airway epithelial cells. Transient expression of active (SGK1-S422D) and inactive (SGK1-K127A) SGK1 mutants confirmed that activating SGK1 stimulates NDRG1-Thr(346/356/366) phosphorylation. Although G (Na) is negligible in hormone-deprived cells, these cells displayed basal SGK1 activity that was sensitive to LY294002, an inhibitor of 3-phosphatidylinositol phosphate kinase (PI3K). Dexamethasone (0.2 mu M) acutely activated SGK1 and the peak of this response (2-3 h) coincided with the induction of G (Na), and both responses were PI3K-dependent. While these data suggest that SGK1 might mediate the rise in G (Na), transient expression of the inactive SGK1-K127A mutant did not affect the hormonal induction of G (Na) but did suppress the activation of SGK1. Dexamethasone-treated cells grown on permeable supports formed confluent epithelial sheets that generated short circuit current due to electrogenic Na+ absorption. Forskolin and insulin both stimulated this current and the response to insulin, but not forskolin, was LY294002-sensitive and associated with the activation of SGK1. While these data suggest that SGK1 is involved in the control of G (Na), its role may be minor, which could explain why sgk1 knockout has different effects upon different tissues.

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We present new observations of 470 stars using the Fibre Large Array Multi-Element Spectrograph ( FLAMES) instrument in fields centered on the clusters NGC330 and NGC346 in the Small Magellanic Cloud (SMC), and NGC2004 and the N11 region in the Large Magellanic Cloud (LMC). A further 14 stars were observed in the N11 and NGC330 fields using the Ultraviolet and Visual Echelle Spectrograph (UVES) for a separate programme. Spectral classifications and stellar radial velocities are given for each target, with careful attention to checks for binarity. In particular, we have investigated previously unexplored regions around the central LH9/LH10 complex of N11, finding similar to 25 new O-type stars from our spectroscopy. We have observed a relatively large number of Be-type stars that display permitted Fe II emission lines. These are primarily not in the cluster cores and appear to be associated with classical Be-type stars, rather than pre main-sequence objects. The presence of the Fe II emission, as compared to the equivalent width of Ha, is not obviously dependent on metallicity. We have also explored the relative fraction of Be- to normal B-type stars in the field-regions near to NGC330 and NGC2004, finding no strong evidence of a trend with metallicity when compared to Galactic results. A consequence of service observations is that we have reasonable time-sampling in three of our FLAMES fields. We find lower limits to the binary fraction of O- and early B-type stars of 23 to 36%. One of our targets (NGC346-013) is especially interesting with a massive, apparently hotter, less luminous secondary component.

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Context. NGC 346-013 is a peculiar double-lined eclipsing binary in the Small Magellanic Cloud (SMC) discovered by the VLT-FLAMES survey of massive stars.

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