Prognostic value of sentinel node biopsy in 327 prospective melanoma patients from a single institution

AIM: To confirm the accuracy of sentinel node biopsy (SNB) procedure and its morbidity, and to investigate predictive factors for SN status and prognostic factors for disease-free survival (DFS) and disease-specific survival (DSS). MATERIALS AND METHODS: Between October 1997 and December 2004, 327 consecutive patients in one centre with clinically node-negative primary skin melanoma underwent an SNB by the triple technique, i.e. lymphoscintigraphy, blue-dye and gamma-probe. Multivariate logistic regression analyses as well as the Kaplan-Meier were performed. RESULTS: Twenty-three percent of the patients had at least one metastatic SN, which was significantly associated with Breslow thickness (p<0.001). The success rate of SNB was 99.1% and its morbidity was 7.6%. With a median follow-up of 33 months, the 5-year DFS/DSS were 43%/49% for patients with positive SN and 83.5%/87.4% for patients with negative SN, respectively. The false-negative rate of SNB was 8.6% and sensitivity 91.4%. On multivariate analysis, DFS was significantly worsened by Breslow thickness (RR=5.6, p<0.001), positive SN (RR=5.0, p<0.001) and male sex (RR=2.9, p=0.001). The presence of a metastatic SN (RR=8.4, p<0.001), male sex (RR=6.1, p<0.001), Breslow thickness (RR=3.2, p=0.013) and ulceration (RR=2.6, p=0.015) were significantly associated with a poorer DSS. CONCLUSION: SNB is a reliable procedure with high sensitivity (91.4%) and low morbidity. Breslow thickness was the only statistically significant parameter predictive of SN status. DFS was worsened in decreasing order by Breslow thickness, metastatic SN and male gender. Similarly DSS was significantly worsened by a metastatic SN, male gender, Breslow thickness and ulceration. These data reinforce the SN status as a powerful staging procedure

Sanción para el acreedor por el desvío de recursos del crédito refaccionario según el artículo 327 de la LGTOC

Tesis ( Maestría en Derecho Mercantil) U.A.N.L.

Índice bibliográfico de la revista de educación de los números 327-329 y número extraordinario año 2002.

Contiene cuatro tipos de índices que facilitan la búsqueda de los artículos incluidos en los números 327 a 329. Estos índices agrupan los artículos por las notaciones de la Clasificación Decimal Universal (CDU) y por orden alfabético de autores, títulos y descriptores.

Ms.Ff.F.Stoltze 3. 327 - Brief von Friedrich Stoltze an Emil Claar

Sein Festspiel (100 Jahre Stadttheater), Dank für die Aufführung

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 327 - Dankesschreiben an Professor Hugo von Meltzl wegen der zugesandten Bibliographie und Bitte um Erwerb von bereits vergriffener Sekundärliteratur

u.a.: Ferdinand Laban; Arthur Schopenhauer;

Mario Garvin. Scripta manent. Hacia una edición crítica del romancero impreso (siglo XVI), Frankfurt/M. : Vervuert, 2007, 327 pp.

Fil: Ennis, Juan Antonio. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.