112 resultados para 2792


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"22 August 1961."

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A polycaprolactone (PCL)–collagen electrospun mesh is proposed as a novel alternative to the conventional periosteal graft in autologous chondrocyte implantation. This is the first known attempt in designing a cartilage resurfacing membrane using a mechanically resilient PCL mesh with a weight-average molecular weight of 139 300 that is enhanced with bioactive collagen. PCL–collagen 10, 20 and 40% electrospun meshes (Coll-10, Coll-20 and Coll-40) were evaluated and it was discovered that the retention of surface collagen could only be achieved in Coll-20 and Coll-40. Furthermore Coll-20 was stiffer and stronger than Coll-40 and it satisfied the mechanical demands at the cartilage implant site. When seeded with mesenchymal stem cells (MSCs), the cells adhered on the surface of the Coll-20 mesh and they remained viable over a period of 28 days; however, they were unable to infiltrate through the dense meshwork. Cell compatibility was also noted in the chondrogenic environment as the MSCs differentiated into chondrocytes with the expression of Sox9, aggrecan and collagen II. More importantly, the mesh did not induce a hypertrophic response from the cells. The current findings support the use of Coll-20 as a cartilage patch, and future implantation studies are anticipated.

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This paper presents a general, global approach to the problem of robot exploration, utilizing a topological data structure to guide an underlying Simultaneous Localization and Mapping (SLAM) process. A Gap Navigation Tree (GNT) is used to motivate global target selection and occluded regions of the environment (called “gaps”) are tracked probabilistically. The process of map construction and the motion of the vehicle alters both the shape and location of these regions. The use of online mapping is shown to reduce the difficulties in implementing the GNT.

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Document the virulence spectra of the major foliar pathogens of barley and identify novel sources of resistances to same.

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This paper aims at describing a low‐temperature thermal sensor based on superconductor films which can be designed to have required variation of resistance with temperature through an appropriate geometry. Further, it has been shown that the temperature range can be varied to some extent by controlling the bias current.

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Residue types at the interface of protein-protein complexes (PPCs) are known to be reasonably well conserved. However, we show, using a dataset of known 3-D structures of homologous transient PPCs, that the 3-D location of interfacial residues and their interaction patterns are only moderately and poorly conserved, respectively. Another surprising observation is that a residue at the interface that is conserved is not necessarily in the interface in the homolog. Such differences in homologous complexes are manifested by substitution of the residues that are spatially proximal to the conserved residue and structural differences at the interfaces as well as differences in spatial orientations of the interacting proteins. Conservation of interface location and the interaction pattern at the core of the interfaces is higher than at the periphery of the interface patch. Extents of variability of various structural features reported here for homologous transient PPCs are higher than the variation in homologous permanent homomers. Our findings suggest that straightforward extrapolation of interfacial nature and inter-residue interaction patterns from template to target could lead to serious errors in the modeled complex structure. Understanding the evolution of interfaces provides insights to improve comparative modeling of PPC structures.

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A shear-lag model is used to study the mechanical properties of bone-like hierarchical materials. The relationship between the overall effective modulus and the number of hierarchy level is obtained. The result is compared with that based on the tension-shear chain model and finite element simulation, respectively. It is shown that all three models can be used to describe the mechanical behavior of the hierarchical material when the number of hierarchy levels is small. By increasing the number of hierarchy level, the shear-lag result is consistent with the finite element result. However the tension-shear chain model leads to an opposite trend. The transition point position depends on the fraction of hard phase, aspect ratio and modulus ratio of hard phase to soft phase. Further discussion is performed on the flaw tolerance size and strength of hierarchical materials based on the shear-lag analysis.

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El presente trabajo es una investigación de campo de tipo descriptivo, documental, no experimental y se realizó según las normativas de la Universidad Nacional Agraria. En primer lugar, se realizaron las visitas a las comunidades de San Isidro y La Laguna Negra con el propósito de observar y conocer la situación socioe conómica de las familias y a la vez conseguir el involucramiento y aprobación de la población para la utilización de las casas comunales de una forma viable y su mejoramiento. Se utilizó el método matricial para elegir una idea de negocio a ejecutar y desarrollarla en ambas casas comunales, siendo electa la elaboración de un plan de negocio que incluye la venta de abarrotes, medicinas y herramientas del campo. Los resultados están basados a la estructura de un Plan de Negocios, teniendo unas compras proyectadas para el primer mes de C$ 109,867.09 y unas ventas de C$ 128,461.98 en ambas casas obteniendo una ganancia de C$ 18,594.89; con una ganancia anual de C$ 223,138.68. Para la iniciación del negocio se pretende realizar un crédito de C$ 243,796.49 con una tasa de interés del 14%, con pagos anuales; se obtuvo un valor actual neto de 82,510.62 y una tasa de interés rentable de 19.34%. Como la idea principal era la mejora de las casas comunales se ejecutó la elaboración de un presupuesto de inversión el cual asume una cantidad de C$ 112,929.40 (Ciento doce mil novecientos veinte y nueve córdobas con 40/100); la cual se incluirá en la inversión inicial sustentada en el financiamiento.

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(PDF file contains 28 pages.)