Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and approximately 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-)(8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

Diário da Constituinte [gravação de vídeo] : [programa n. 249]

O substitutivo do Relator Bernardo Cabral (PMDB-AM) garante a todas as crianças e adolescentes o acesso à educação, saúde, lazer, alimentação e proteção contra a violência. O Deputado José Teixeira (PFL-MA) afirma que os constituintes devem assegurar às crianças os direitos fundamentais. O Deputado Robson Marinho (PMDB-SP) informa que a aprovação do texto do substitutivo representará um grande avanço nos direitos das crianças. No Plenário da Assembleia Nacional Constituinte (ANC), constituintes discutiram diversos assuntos. O Deputado Jesualdo Cavalcanti (PFL-PI) critica o substitutivo no que se refere a questão dos cartórios. Líderes dos partidos reunidos para agilizar as votações. O Líder do PL, Deputado Adolfo de Oliveira (PL-RJ) considera que o prazo de votação não pode comprometer os trabalhos da Assembleia Nacional Constituinte (ANC). A votação na Comissão de Sistematização da Assembleia Nacional Constituinte (ANC) começou a ser feita em ritmo mais acelerado. O primeiro debate do dia foi sobre o trabalho forçado para os presos, mas a proposta foi rejeitada. O Deputado Vivaldo Barbosa (PDT-RJ) afirma ser favorável ao trabalho obrigatório dos presos. A discussão mais importante foi a da pena de morte. O Líder do PDS, Deputado Amaral Neto (PDS-RJ) defendeu-a para casos extremos, em crimes de uma violência hedionda. O Deputado José Serra (PMDB-SP) discorda e declara que os países que aboliram a pena de morte, como a França, Inglaterra e regiões dos Estados Unidos, não tiveram nenhum aumento de criminalidade. A proposta da pena de morte foi rejeitada por 84 votos contra 5.

A. Renaut. Sartre, le dernier philosophe, Grasset, 1993, 249 pages.

Bruxelles/New-Haven

HG 249.40-249.55 Thin Section

Coarse grained sample with clasts ranging from small to medium. Clast shape ranges from angular to sub-angular. Lineations and rotation structures seen. Clay material and fine grained domains (darker colour) also seen.

Carta geotécnica de suscetibilidade aos processos da dinâmica superficial do trecho KM 215 ao 249 da Rodovia Marechal Rondon - SP-300

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Morgan Reeves Papers- Accession 249 - M105 (135)

Morgan Reeves (1841-1928) was a Confederate Soldier during the American Civil War in Company I of the 13th South Carolina Regiment. He was also an exchanged prisoner at Camp Lee, near Richmond, VA on March 20, 1865. The Morgan Reeves Papers consist of photocopies of company, hospital, receipt rolls, and a morning report of Company I of the 13th South Carolina Regiment of the Confederate Army. The collection is all photocopies.

Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies

In a retrospective cohort study undertaken in 12 European countries, 249 female narcoleptic patients with cataplexy (n = 216) and without cataplexy (n = 33) completed a self-administrated questionnaire regarding pregnancy and childbirth. The cohort was divided further into patients whose symptoms of narcolepsy started before or during pregnancy (308 pregnancies) and those in whom the first symptoms of narcolepsy appeared after delivery (106 pregnancies). Patients with narcolepsy during pregnancy were older during their first pregnancy (P < 0.001) and had a higher body mass index (BMI) prior to pregnancy (P < 0.01). Weight gain during pregnancy was higher in narcoleptic patients with cataplexy (P < 0.01). More patients with narcolepsy-cataplexy during pregnancy had impaired glucose metabolism and anaemia. Three patients experienced cataplexy during delivery. The rate of caesarean sections was higher in the narcolepsy-cataplexy group compared to the narcolepsy group (P < 0.05). The mean birth weight and gestational age of neonates were within the normal range and did not differ across groups. Neonatal care was affected adversely by symptoms of narcolepsy in 60.1% of those with narcolepsy during pregnancy. This study reports more obstetric complications in patients with narcolepsy-cataplexy during pregnancy; however, these were not severe. This group also had a higher BMI and higher incidence of impaired glucose metabolism during pregnancy. Caesarian section was conducted more frequently in narcolepsy-cataplexy patients, despite cataplexy being a rare event during delivery. Furthermore, symptoms of narcolepsy may render care of the infant more difficult.

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 249 - Mitteilung über das weitere Verfahren mit den mexikanischen Anleihen

u.a.: anhängender Kommentar Schopenhauers;