不同药物对心理应激猕猴的抗应激作用

以心理应激猕猴为动物模型,比较研究了狒猴应激前后外周血中ACTH、皮质醇、胰岛素以及游离T_(3),T_(4)的变化,并对安定、心得安等药物的抗应激效应进行了初步的探讨。实验结果表明,在应激前后,ACTH、皮质醇呈显著性差异(P<0.05和P<0.01),胰岛素呈上升趋势。安定可使应激动物的ACTH、皮质醇的水平明显降低(P<0.05),但是,对FT_(3),FT_(4)的影响不明显。心得安对各种激素无明显影响。

Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.

Genome-wide association studies (GWAS) have identified ten loci harboring common variants that influence risk of developing colorectal cancer (CRC). To enhance the power to identify additional CRC risk loci, we conducted a meta-analysis of three GWAS from the UK which included a total of 3,334 affected individuals (cases) and 4,628 controls followed by multiple validation analyses including a total of 18,095 cases and 20,197 controls. We identified associations at four new CRC risk loci: 1q41 (rs6691170, odds ratio (OR) = 1.06, P = 9.55 × 10?¹° and rs6687758, OR = 1.09, P = 2.27 × 10??, 3q26.2 (rs10936599, OR = 0.93, P = 3.39 × 10?8), 12q13.13 (rs11169552, OR = 0.92, P = 1.89 × 10?¹° and rs7136702, OR = 1.06, P = 4.02 × 10?8) and 20q13.33 (rs4925386, OR = 0.93, P = 1.89 × 10?¹°). In addition to identifying new CRC risk loci, this analysis provides evidence that additional CRC-associated variants of similar effect size remain to be discovered.

A política externa dos Estados Unidos e a trajetória do desenvolvimento cubano

O artigo analisa as características do desenvolvimento da economia cubana após a revolução de 1959, destacando os seguintes aspectos: a) o nível de interferência representado pela política externa dos Estados Unidos; b) de que maneira a opção pelo modelo econômico e político adotado por Cuba possibilitou o desencadeamento da crise atual e afetou a capacidade de enfrentá-la; c) que perspectivas se abrem para as relações com os Estados Unidos após o fim da Guerra Fria.

Paleoelevations in the Pacific Ocean 35 million years ago

Data from deep sea drilling, linear magnetic anomalies and bathymetric measurements together with age and morphometric characteristics of seamounts have been used to construct a paleobathymetric map of the oceans 35 million years ago. A brief analysis of these results is presented.

(Tables 1-3) Pb and Sr isotopic data for sediments and rocks from DSDP holes in the Mariana island-arc system

Analyses of the isotopic composition of Pb in (1) western Pacific Ocean sediments [Jurassic(?) to Pleistocene in age, including clays and biogenic oozes], (2) Pacific Ocean basaltic rocks, (3) Mariana frontal arc volcanic rocks (Eocene to Miocene), and (4) Mariana active arc volcanic rocks [Pliocene (?) to Holocene] indicate that Pacific Ocean sediments could not have been a significant component of the source material for the Mariana arc volcanic rocks. Calculations involving the average concentrations and isotopic compositions of Pb in oceanic sediments, sea-floor basaltic rocks, and the Mariana arc volcanic rocks suggest that the sediment component must have been less than 1 percent of this source material. The Pb isotopic compositions of the Mariana arc volcanic rocks lie, within experimental error, along the trend of available Pacific Ocean basalt analyses in versus 207Pb/204Pb versus 206Pb/204Pb and 208Pb/204Pb versus 206Pb/204Pb diagrams. Isotopic analyses of Pb in Pacific Ocean sediments do not lie along this trend; they have higher 207Pb/204Pb and 208Pb/204Pb values for comparable 206Pb/204Pb ratios. Clayey sediments generally have higher 208Pb/204Pb and 207Pb/204Pb ratios than biogenic oozes regardless of the age of the sediment. Comparison of combined Sr and Pb isotopic analyses for (1) mantle-derived materials erupted through oceanic crust, (2) altered ocean-floor basaltic rocks, and (3) volcanic rocks from oceanic island arcs suggests that the Mariana arc volcanic rocks were derived, at least in part, from altered Pacific lithosphere subducted beneath the Mariana arc. Unaltered basalts from the Mariana inter-arc basin (Mariana Trough) have Pb and Sr isotopic compositions that are very similar to those reported for some Hawaiian volcanic rocks but distinct from Mariana active and frontal arc compositions. These observations, in addition to existing major-and trace-element data, support a mantle origin for the interarc basin volcanic rocks. Dacites dredged from the Mariana remnant arc (South Honshu Ridge) have Pb isotopic compositions that are within experimental error of the active-arc analyses, consistent with a genetic relation.

Resolución 197 del 20 de diciembre de 2012: Por medio de la cual resuelve un recurso de reposición

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~(197)Os的合成和衰变

用14MeV中子轰击Pt,通过198Pt(n,2p)反应产生197Os。用高纯锗探测器观测197Os的衰变γ射线,获得了10条新γ射线,并指定为197Os的衰变,测定它的半衰期为2.8±0.6min。根据γ(X)-γ符合测量,建议一个197Os的部分衰变纲图。

用于~(18)N在~9Be、~(197)Au靶上破裂反应研究的探测器系统

描述了用于放射性核束 18N在 9Be、197Au靶上破裂反应研究的探测器系统构成、性能、特点及在线实验的初步结果。