Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis.

Adenine phosphoribosyltransferase (APRT) deficiency in humans is an autosomal recessive syndrome characterized by the urinary excretion of adenine and the highly insoluble compound 2,8-dihydroxyadenine (DHA) that can produce kidney stones or renal failure. Targeted homologous recombination in embryonic stem cells was used to produce mice that lack APRT. Mice homozygous for a null Aprt allele excrete adenine and DHA crystals in the urine. Renal histopathology showed extensive tubular dilation, inflammation, necrosis, and fibrosis that varied in severity between different mouse backgrounds. Thus, biochemical and histological changes in these mice mimic the human disease and provide a suitable model of human hereditary nephrolithiasis.

Halogenated terpenoids. XXXII - Pentabromides from limonene two 1,2,8,9,9-pentabromo-p-menthanes

The problems of structure in diastereomers where one chiral centre is remote from another are further investigated in the 1,2,8,9,9-pentabromo-p-menthane series.

Tasavallan Presidentin vastauspuhe Maailman rauhanneuvoston edustajille Joliot Curie -mitalin luovutustilaisuudessa 2.8.1975

Puhe

Hki 2/8 -28

Kirje 2.8.1928

Hinassa 2.8.1943

Kirje

Angervonniemi 2.8.1936

Kirje

Anthologium epigrammatum Graecorum 2:8

Painovuosi nimekkeestä.

Suomen taloudellinen kartta 1:100000 = Ekonomisk karta över Finland 1:100000 - 2:8, Kotka

0-meridiaani : Helsinki.

Suomen taloudellinen kartta 1:100000: (kihlakunnankartta) = Finlands ekonomiska karta 1:100000 : (häradskarta) - Lehti = Blad 2:8, Suursaari = Hogland

0-meridiaani : Helsinki.

Suomen taloudellinen kartta 1:100000: (kihlakunnankartta) = Finlands ekonomiska karta 1:100000 : (häradskarta) - Lehti = Blad 1:8, 2:8, Kotka

0-meridiaani : Helsinki.

Electronic structure calculations of small AI_n (n = 2 - 8) clusters

The electronic states of small AI_n (n = 2 - 8) clusters have been calculated with a relativistic ab-initio MOLCAO Dirac-Fock-Slater method using numerical atomic DFS wave-functions. The excitation energies were obtained from a ground state calculation of neutral clusters, and in addition from negative clusters charged by half an electron in order to account for part of the relaxation. These energies are compared with experimental photoelectron spectra.

Burnt offerings and harpies at Nasidienus’ dinner-party (Horace, Satires 2.8)

Horace's last Satire describes a disastrous dinner party hosted by the gourmet Nasidienus, which is ruined by a collapsing tapestry. The food served afterwards is presented in a dismembered state. This chapter argues that several elements of the scene recall the greedy Harpies of Apollonius' Argonautica, and that Horace's friend Virgil shows the influence of this Satire in his own Harpy-scene in Aeneid 3. It also argues that the confusion in the middle of the dinner causes the food cooking in the kitchen to be neglected and burned. This explains the state of the subsequent courses, which Nasidienus has salvaged from a separate disaster backstage.