992 resultados para 1995_03171550 TM-10 4500604


Relevância:

100.00% 100.00%

Publicador:

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Introduction Behavioural interventions have been shown to improve outcomes in patients with type 1 diabetes mellitus (T1DM). There are a small number of studies that suggest text-messages (TM), native mobile applications (NMAs), and other mobile tools may be useful platforms for delivering behavioural interventions to adolescents. Aim The aim of this study was to explore, by way of a systematic review of available literature, (a) the outcomes of interventions using mobile technology for youth with T1DM and (b) what mobile technologies, functional design elements and aesthetic design elements have the best evidence to support their use. Methods A search of six online databases returned 196 unique results, of which 13 met the inclusion criteria. Results Four studies were randomised controlled trials (RCTs), and all others prospective cohort studies. TM (10) was the most common intervention technology, while NMAs were used in four studies. The most common outcome measured was HbA1c (9); however, only three studies showed a significant decrease. Similarly, the results reported for other outcome measures were mixed. The studies included in this review suggest that interventions which have data collection and clinician support functionality may be more effective in improving adherence and glycaemic control, but more evidence is needed. Further, the evidence base supporting the use of NMAs in T1DM management for adolescents is weak, with most studies adopting TM as the intervention tool. Overall, the studies lack adequate descriptions of their methodology, and better quality studies are required to inform future intervention design.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

研制了有源区为InGaAs张应变体材料的1.55μm偏振不灵敏半导体光放大器(SOA)。采用束传播法计算了偏离镜面垂直方向7°的埋层波导结构模式场分布,并用平面波展开法设计了多层抗反射膜,在TE模和TM模反射率同时小于10^-4时膜厚允许误差为3%。对放大自发发射谱(ASE)和增益谱的分析表明,他们具有基本一致的偏振灵敏度。对一腔长800μm的SOA在注入电流250mA时,测量得出TE模和TM模的ASE谱偏振灵敏度小于0.5dB,增益谱3dB带宽为63nm,1550nm处光纤到光纤增益为11.9dB,3dB饱和输出功率为5.6dB,在1570nm处的噪声指数为7.8dB。而一腔长1000μmSOA耦合封装后得到的最大增益为15dB。

Relevância:

100.00% 100.00%

Publicador:

Resumo:

报道铥(Tm)原子10个中等能量激发能级自然辐射寿命的实验测量值.采用两台脉冲染料激光器将铥原子从基态激发到待测能级,再从铥原子激发态所释放的荧光随时间衰变的规律推算出自然辐射寿命值.测量精确度为10%.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

The isoflavone genistein is found predominantly in soyabeans and is thought to possess various potent biological properties, including anticarcinogenic effects. Studies have shown that genistein is extensively degraded by the human gut microflora, presumably with a loss of its anti-carcinogenic action. The aim of the present study was to investigate the potential of a prebiotic to divert bacterial metabolism away from genistein breakdown: this may be of benefit to the host. Faecal samples were obtained from healthy volunteers and fermented in the presence of a source of soyabean isoflavones (Novasoy(TM) (10 g/l); ADM Neutraceuticals, Erith, Kent, UK). Bacterial genera of the human gut were enumerated using selective agars and genistein was quantified by HPLC. The experiment was repeated with the addition of glucose (10 g/l) or fructo-oligosaccharide (10 g/l; FOS) to the fermentation medium. The results showed most notably that counts of Bifidobacterium spp. and Lactobacillus spp. were significantly increased (P<0.05 and P<0.01 respectively) under steady-state conditions in the presence of FOS. Counts of Bacteroides spp. and Clostridium spp. were, however, both significantly reduced (P<0.05) during the fermentation. A decline in genistein concentration by about 52 and 56% over the 120h culture period was observed with the addition of glucose or FOS to the basal medium (P<0.01), compared with about 91% loss of genistein in the vessels containing Novasoy(TM) (ADM Neutraceuticals) only. Similar trends were obtained using a three-stage chemostat (gut model), in which once again the degradation of genistein was about 22% in vessel one, about 24% in vessel two and about 26% in vessel three in the presence of FOS, compared with a degradation of genistein of about 67% in vessel one, about 95% in vessel two and about 93% in vessel three in the gut model containing Novasoy(TM) (ADM Neutraceuticals) only. The present study has shown that the addition of excess substrate appeared to preserve genistein in vitro. In particular, the use of FOS not only augmented this effect, but also conferred an additional benefit in selectively increasing numbers of purportedly beneficial bacteria such as bifidobacteria and lactobacilli.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

The visual system is an important link between the animal and the environment, com profound influences on the habits and lifestyle in various habitats. Adaptive mechanismsto the temporal niche are present in the visual system of many vertebrates, involving changins in ocular dimensios and design, retinal cell distribution and organization of neurochemical circuits related to the retinal resolution or sensitivity. The sensory system of the eye is represented by the retina, whose organization is responsible by receipty, initial analysis, and transmission of the information to the brain. The knowledge of the position of the eyes in the head and the distribution of retinal cells allow to identify adaptive aspects of each species to its visual field, which is characteristic to the ecological niche it occupies. In this research, we study eye anatomical characteristics and retina neurochemical features of the rock cavy (Kerodon rupestris), a tipical Brazilian rodent from the suborder Hystricomorpha, family Caviidae. The rock cavy has lateral eyes well constitute bony orbit and well differentiated extrinsic muscle. The study of the descriptive and morphometric anatomy of the showed mean values of axial diameter 10.7±0,5mm and equatorial diameter 11.6±0.7mm. The pupil is slit shaped and the lens has mean axial diameter 5.4±0.03 mm, corresponding to ~45% of the axial diameter of the eye. The posterior nodal distance and the retinal magnification factor were estimated at 6.74 mm e 118 μm/grau, respectively. Flat mounts were processed for Nissl stain, and the topographic distribution of ganglion cells showed a moderate visual band, just below the optic disc, with higher density in the ventral retina. Retinal vertical sections and flat mounts were processed for immunohistochemistry to visualize tyrosine hydroxilase (TH) and thus two types of TH+ cells were detected. Type 1 cells had strong TH-immunoreactivity, the body cell varied from 120.047 to 269.373 μm2 stratifying in the sublamina 1 of the IPL. Type 2 cells were weakly TH-imunoreactive, had cell body located mostly in the IPL, varying from 54.848 to 177.142 μm2, constituting ~10% of the TH+ cells. Both cell types exhibited similar topographic distribution with higher density found in a horizontal band along of the naso-temporal axis in the dorsal retina. The total population of dopaminergic cells was 2,156±469,4 cells, occupying an average area of 198,164 μm2. The presence of cones and rods was detected by immunohistochemistry in vertical sections and flat mounts. S cones density is around 10 times smaller than L cones, with different degree of spatial organization. Other retinal neuronal populations of the rock cavy were also detected in vertical sections with specific markers. Comparative analysis of the anatomical characteristics of the rock cavy eye 12 suggest that it was designed to acquire higher sensitivity to light, at expense of image sharpness, compatible with a vision at mesopic conditions. Additionally, the distribution of the 2 subtypes of dopaminergic cells in a naso-temporal band in the dorsal retina seems suitable to a gain in sensitivity, coherent with an animal with predominantly crepuscular activity pattern

Relevância:

100.00% 100.00%

Publicador:

Resumo:

O presente trabalho teve como objetivo principal caracterizar a variação prosódica dialetal do português falado na zona rural da cidade de Belém (PA), distrito de Mosqueiro. A pesquisa de campo foi feita com base na metodologia utilizada pelo projeto AMPER, com o corpus constituído de 102 frases, obedecendo às mesmas restrições fonético-sintáticas. Dessa forma, as frases utilizadas nas gravações para a composição do corpus da zona rural de Belém analisadas neste trabalho são do tipo SVC (Sujeito + Verbo + complemento) e suas expansões com a inclusão de Sintagmas Adjetivais e Adverbiais. As sentenças do corpus têm 10, 13 e 14 vogais, sendo que os dois últimos tipos apresentam sintagma com extensão adjetival ou adverbial, respectivamente, à direita do verbo, como em “O pássaro gosta do Renato nadador” ou “O pássaro gosta do Renato de Mônaco”. Cada sentença foi repetida seis vezes, formando um corpus total de 612 frases por cada informante. Os parâmetros acústicos utilizados foram: a duração, a frequência fundamental e a intensidade. A análise dos parâmetros foi feita por meio de dados gerados nos aplicativos PRAAT, Interface MatLab e gráficos gerados no Excel. A pesquisa reuniu dados referentes a seis informantes adultos, de ambos os sexos, com nível de escolaridade fundamental, médio e superior. Os resultados forneceram um desenho entoacional comparativo entre as frases declarativas e interrogativas, além de breves observações sobre o comportamento das vogais pretônicas, postônicas e tônicas, de acordo com as estruturas acentuais e das palavras em diferentes posições frásicas. O foco foi direcionado para o Sintagma Nominal Final e suas extensões sobre o qual verificamos que a sentença interrogativa inicia sua curva melódica baixa em decorrência do pico entoacional no verbo “gosta”, e posterior ascendência na sílaba tônica; e a declarativa inicia a curva com ascendência até a pré-tônica e posterior descendência no final do percurso melódico.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

A presente pesquisa está vinculada ao projeto AMPER-NORTE (Atlas Multimídia Prosódico do Norte do Brasil), que faz parte do AMPER-POR (Atlas Multimídia Prosódico do Português). Este estudo contribuirá com a formação do Atlas Multimídia Prosódico do Norte do Brasil e tem como objetivo principal caracterizar a variedade dialetal prosódica do português falado na zona urbana do município de Baião (PA). Todos os procedimentos metodológicos adotados seguem as orientações estabelecidas pela coordenação geral do Projeto AMPER - POR. O corpus é formado com seis informantes e 66 frases, estruturadas sintaticamente em SVC (sujeito + verbo + complemento) e suas expansões (sintagma adjetival e sintagma preposicional), obedecendo as mesmas restrições fonéticas e sintáticas e mantendo o padrão dos corpora constituídos por variedades do português do projeto AMPER –POR. As sentenças do corpus têm 10, 13 e 14 vogais e todas as frases foram repetidas seis vezes por cada informante formando um corpus total de 396 frases. Os dados foram coletados com três homens e três mulheres, dos níveis de escolaridade fundamental, médio e superior, com idade entre 35 a 75 anos. O corpus selecionado é constituído de 42 frases – 21 declarativas e 21 interrogativas – que contemplam as três pautas acentuais do português. Em todas as sentenças foram analisadas as modalidades declarativas e interrogativas, e as análises acústicas das vogais foram feitas em seis etapas. Os parâmetros acústicos analisados foram: Frequência Fundamental (semitons), duração (ms) e intensidade (dB). Os resultados desse estudo demonstraram que o parâmetro acústico de F0 é o mais relevante na distinção entre enunciados declarativos e interrogativos. Observou-se, tanto nos sintagmas nominais finais simples quanto nos compostos, um contorno entoacional em formato de “pinça” no último sintagma nominal final dos vocábulos, e esse movimento mostra que a F0 é descendente para as modalidades declarativas e ascendente para as frases interrogativas. A duração (ms) complementa a F0 na distinção das duas modalidades frasais. Já a intensidade (dB) não se mostrou um parâmetro relevante para distinguir as sentenças declarativas e interrogativas na variedade falada em Baião (PA).