Understanding the abnormal brain activity in epilepsy as a potential predictor of the onset of an epileptic seizure

The Brain Research Institute (BRI) uses various types of indirect measurements, including EEG and fMRI, to understand and assess brain activity and function. As well as the recovery of generic information about brain function, research also focuses on the utilisation of such data and understanding to study the initiation, dynamics, spread and suppression of epileptic seizures. To assist with the future focussing of this aspect of their research, the BRI asked the MISG 2010 participants to examine how the available EEG and fMRI data and current knowledge about epilepsy should be analysed and interpreted to yield an enhanced understanding about brain activity occurring before, at commencement of, during, and after a seizure. Though the deliberations of the study group were wide ranging in terms of the related matters considered and discussed, considerable progress was made with the following three aspects. (1) The science behind brain activity investigations depends crucially on the quality of the analysis and interpretation of, as well as the recovery of information from, EEG and fMRI measurements. A number of specific methodologies were discussed and formalised, including independent component analysis, principal component analysis, profile monitoring and change point analysis (hidden Markov modelling, time series analysis, discontinuity identification). (2) Even though EEG measurements accurately and very sensitively record the onset of an epileptic event or seizure, they are, from the perspective of understanding the internal initiation and localisation, of limited utility. They only record neuronal activity in the cortical (surface layer) neurons of the brain, which is a direct reflection of the type of electrical activity they have been designed to record. Because fMRI records, through the monitoring of blood flow activity, the location of localised brain activity within the brain, the possibility of combining fMRI measurements with EEG, as a joint inversion activity, was discussed and examined in detail. (3) A major goal for the BRI is to improve understanding about ``when'' (at what time) an epileptic seizure actually commenced before it is identified on an eeg recording, ``where'' the source of this initiation is located in the brain, and ``what'' is the initiator. Because of the general agreement in the literature that, in one way or another, epileptic events and seizures represent abnormal synchronisations of localised and/or global brain activity the modelling of synchronisations was examined in some detail. References C. M. Michel, G. Thut, S. Morand, A. Khateb, A. J. Pegna, R. Grave de Peralta, S. Gonzalez, M. Seeck and T. Landis, Electric source imaging of human brain functions, Brain Res. 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Posthumous conception in South Australia : the case continues in Re H, AE (No 3) [2013] SASC 196

This editorial considers the issue of posthumous conception as discussed in the case of Re H, AE (No 3) [2013] SASC 196, which involved an application by a South Australian woman to the Supreme Court for authorisation to export her deceased partner's sperm to the Australian Capital Territory, for use in an assisted reproductive technology procedure.

Phase relations in the system SrO-Y2O3-CuO-O2 and CaO-Y2O3-CuO-O2 at 1173 K

Phase relations in the systems SrO-Y2O3-CuO-O2 and CaO-Y2O3-CuO-O2 at 1173 K were established by equilibrating different compositions in flowing oxygen gas at a pressure of 1.01 × 105 Pa. The quenched samples were examined by optical microscopy, X-ray diffraction (XRD), energy dispersive analysis of X-rays (EDAX), and electron spin resonance (ESR). In the system SrO-Y2O3-CuO-O2, except for the limited substitution of Y3+ for Sr2+ ions in the ternary oxide Sr14Cu24O41, no new quaternary phase was found to be stable. The compositions corresponding to the solid solution Sr14−xYxCu24O41 and the compound SrCuO2+δ lie above the plane containing SrO, Y2O3, and CuO,displaced towards the oxygen apex. However, in the system CaO-Y203-CuO-O2 at 1173 K, all the condensed phases lie on the plane containing CaO, Y203, and CuO, and a new quaternary oxide YCa2Cu306.s is present. The quaternary phase has a composition that lies at the center of the nonstoichiometric field of the analogous phase YBa2Cu307_~ in the BaO-Y203-CuO-O2 system. The compound YCa2Cu306.s has the tetragonal structure and does not become superconducting at low temperature. Surprisingly, phase relations in the three systems CaO-Y203-CuO-O2, SrO-Y203-CuO-O2, and BaO-Y203-CuO-O2 are found to be quite different.

Sapientia, 1995, Vol. L, nº 195-196 (número completo)

Contenido: Naturaleza humana y gracia : el problema del humanismo cristiano / Octavio Nicolás Derisi – La moral de Tomás de Aquino en el Catecismo de la Iglesia Católica / Héctor Aguer – Santo Tomás de Aquino en la encíclica Veritatis Splendor de Juan Pablo II / Gustavo Eloy Ponferrada – La ética cartesiana entre teleología y deontología / Antonio Malo Pé – Por qué la filosofía de la naturaleza de Hegel es la parte más débil de sus sistema / Juan Alfredo Casaubon – Igualdad (ligelighed) y diferencia (forskjel) : en torno a la comunidad fraternal de S. Kierkegaard / Francisco Torralba Roselló – Metafísica de la libertad en Carlos Cardona / Eudaldo Forment – La normatividad de la naturaleza y los absolutos morales / Carlos Ignacio Massini Correas – El pecado colectivo : existencia y naturaleza / Victorino Rodríguez – The sacramental visión of lonergan’s grace and freedom / John M. McDermott – La afirmación de la trascendencia de Dios en la doctrina cristiana y en las conclusiones de la filosofía primera / Mario Enrique Sacchi – Notas y comentarios -- Bibliografía

Diário da Constituinte [gravação de vídeo] : [programa n. 196]

Representantes do PMDB, PT, PDT, PCB e PCdoB querem mudar o anteprojeto, por considerá-lo conservador. O Deputado Brandão Monteiro (PDT-RJ) declara que o grupo não aceita diversos pontos, tais como a definição do papel das Forças Armadas, a definição de anistia e o voto distrital. O grupo quer tentar mudar esses pontos através de negociação com o Relator Bernardo Cabral e com as lideranças que estão à frente do trabalho. O Deputado Nelton Friederich (PMDB-PR) considera que, caso não haja consenso, a decisão será por voto no Plenário. O Deputado José Genoíno (PT-SP) diz que o grupo tomou consciência da necessidade de agir em conjunto e da força que possui para atingir seus objetivos. Já tem data a entrega do anteprojeto de Constituição do Relator Bernardo Cabral a Comissão de Sistematização da Assembleia Nacional Constituinte (ANC). O Deputado Bernardo Cabral (PMDB-AM) esclarece que não declarou que há um complô a favor do presidencialismo e fala sobre os retoques no texto, nos tópicos da Anistia e da Reforma Agrária. Na sessão O Povo Pergunta cidadão quer saber quais os critérios que estão sendo usados na Assembleia Nacional Constituinte para uma melhor distribuição de renda. O Deputado Samir Achôa (PMDB-SP) responde que o governo deve dar maior amparo aos aposentados e aos inválidos e que a participação de empregados nos lucros das empresas faria justiça a esses trabalhadores.

贺兰山过去196年降水的树轮宽度重建及降水变率

IEECAS SKLLQG

C 196 INST-D 2013. 377 Tejido de lana en telares horizontales grandes de cuatro y más marcos.

15 fotografías, nueve a color y seis en tono de grises.

Français 1173

Contient : 1° « Le Gieu des eskies », par « NICHOLES DE S. NICHOLAÏ », de Lombardie ; 2° « Les Partures des taules » ; 3° Le Jeu « des merelles »

Resolución No. 196: Por la cual se resuelve un recurso de reposición y en subsidio de apelación

Servicios registrales

HG 196.20-196.30 Thin Section

Brown, coarse grained sediment , with clay material. Clasts range from small to large, and sub-angular to sub-rounded. Organic material can be seen. Lineations are abundant. Grain stacking edge-to-edge grain crushing can also be seen. Organic material can be seen. Edge-to-edge grain crushing is seen throughout the image. Contains the inclusion of a finer domain.