Recueil de chroniques relatives à l'histoire de France et d'Angleterre jusqu'en 1434, le tout écrit de la main de Pierre Cochon.

Contient : 1 ; Table indiquant « le jourde Pasquez, depuis l'an mil IIIC. LX jusques à Pasquez l'an mil IIIIC XXIII » ; Notes chronologiques : « Nota que Paris fut fondée IXC. ans après le deluge... Led. Cesar mourut VIIC. VIII ans après la fondation de Romme et avant l'Incarnation de Nostre Seigeur LIII ans » ; Dictons : « En prinche loyalté, en clert humilité... En drap belle coulour, en vin bonne savour » ; Autres dictons : « Pitié de Lombart, labour de Picart... ces VIII choses, pris bon, ne vallent pas un bouton » ; Vers sur Du Guesclin ; 2 « L'extrait des annéez de la Nativité. D'aucuns pappes de Romme, empereurs, rois de Franche et d'Engleterre, dux de Normandie, et autres princes et grans seigneurs qui ont regné, en quel temps et combien, depuis l'an premier de l'Incarnacion Jhesu Christ, qui nasquit de la vierge Marie, si comme vous pourrés voir par ordre en la manière qui s'ensieut : Premierement. L'an I. Nostre Seigneur Jhesu Christ fu né de la vierge Marie, circonsis, offert au temple et envoié par l'angle en essil en Egipte... Mil IIIC. XVIII. La feste du saint sacrement fu ordenée ou temps du pape Urban Quart » ; 3 Fol. 11 à 13 ; 4 « Chy ensuit aucunes memoirez avenueez à Rouen y (sic) ès partiez d'icellez (sic). Premièrement, samedy XXIe jour de jung, l'an mil IIIC. LXXI l'abbé de Saint Ouein de Rouen fist lever une fourquez de souz son boys de Bihorel, et il firent pendre I. larron... » ; Cette chronique s'arrête à 1424 et finit par : «... et leur fist Diex grace de ne morir » ; 5 Chronique dite normande : « Depuis que Godeffroy de Billon et la baronnie de France orent conquis Anthyoce et Jerusalem... » Derniers mots : «... Or parleron d'un cas advenu à la court de l'eglise à Rouen. L'an de grace 1434, le samedi 20e jour de juin,... Et fu en ce ledit Cochon grandement dommagié, car il ne fu à la court ne ailleurs etc. »

Recueil des privilèges accordés par les rois de France à la ville d'Orléans. (1178-1434).

Il y a une table des lettres royaux et autres pièces en tête du volume. — On y remarque la grande ordonnance du Dauphin Charles (mars 1356 [1357]).

Siegelabzug des Erzbischof-Kurfürsten Konrads III [Illustration] : 1419-1434

Scan von Monochrom-Mikroform

Die Beziehungen der Mediceer zu Frankreich : während der Jahre 1434-1490, in ihrem Zusammenhang mit den allgemeinen Verhältnissen Italiens /

1. T., 1. Abschnitt. Cosimo de' Medici. Francesco Sforza. Frankreich (1434-69) 2. Abschnitt. Lorenzo de' Medici. Ludwig IX. Karl VIII. Florenz und Lorenzo unter dem Schutze Frankreichs (1469-1489) 3. Abschnitt. Die Ansprüche Frankreichs. Trennung Pieros de' Medici von Mailand und Bruch nit Frankreich. Sturz des mediceischen Hauses (1489-1494)--2.T. Dokumente und Anmerkungen.

The history of Florence under the domination of Cosimo, Piero, Lorenzo de' Médicis, 1434-1492,

Mode of access: Internet.

Leonardo Bruni, the Medici, and the Florentine histories

Others, like the prominent humanist and anti-Medicean agitator Francesco Filelfo, would soon join the first wave of exiles.4 Bruni was not only linked to such men by ties of patronage and friendship; he had also for many years acted as the chief ideologue of the preMedicean oligarchy.5 One might logically expect that he too would become a victim of Medici vengeance in 1434, or soon thereafter. Other scholars have stressed that Bruni-despite the occasional flamboyance of his civic rhetoric-was always an advocate of restricted government.8 While the power struggle between the Medici and their adversaries was real enough, the system Cosimo and his associates introduced after 1434 differed from its predecessor only in the consistency with which it was applied.

Exercise-induced energy expenditure : implications for exercise prescription and obesity

Objective: Walking is commonly recommended to help with weight management. We measured total energy expenditure (TEE) and its components to quantify the impact of increasing exercise-induced energy expenditure (ExEE) on other components of TEE. Methods: Thirteen obese women underwent an 8-week walking group intervention. TEE was quantified using doubly labeled water, ExEE was quantified using heart rate monitors, daily movement was assessed by accelerometry and resting metabolic rate was measured using indirect calorimetry. Results: Four of the 13 participants achieved the target of 1500 kcal wk−1 of ExEE and all achieved 1000 kcal wk−1. The average ExEE achieved by the group across the 8 weeks was 1434 ± 237 kcal wk−1. Vigorous physical activity, as assessed by accelerometry, increased during the intervention by an average of 30 min per day. Non-exercise activity thermogenesis (NEAT) decreased, on average, by 175 kcal d−1 (−22%) from baseline to the intervention and baseline fitness was correlated with change in NEAT. Conclusions: Potential alterations in non-exercise activity should be considered when exercise is prescribed. The provision of appropriate education on how to self-monitor daily activity levels may improve intervention outcomes in groups who are new to exercise. Practice implications: Strategies to sustain incidental and light physical activity should be offered to help empower individuals as they develop and maintain healthy and long-lasting lifestyle habits.

Preliminary validation of a novel high-resolution melt-based typing method based on the multilocus sequence typing scheme of Streptococcus pyogenes

The major limitation of current typing methods for Streptococcus pyogenes, such as emm sequence typing and T typing, is that these are based on regions subject to considerable selective pressure. Multilocus sequence typing (MLST) is a better indicator of the genetic backbone of a strain but is not widely used due to high costs. The objective of this study was to develop a robust and cost-effective alternative to S. pyogenes MLST. A 10-member single nucleotide polymorphism (SNP) set that provides a Simpson’s Index of Diversity (D) of 0.99 with respect to the S. pyogenes MLST database was derived. A typing format involving high-resolution melting (HRM) analysis of small fragments nucleated by each of the resolution-optimized SNPs was developed. The fragments were 59–119 bp in size and, based on differences in G+C content, were predicted to generate three to six resolvable HRM curves. The combination of curves across each of the 10 fragments can be used to generate a melt type (MelT) for each sequence type (ST). The 525 STs currently in the S. pyogenes MLST database are predicted to resolve into 298 distinct MelTs and the method is calculated to provide a D of 0.996 against the MLST database. The MelTs are concordant with the S. pyogenes population structure. To validate the method we examined clinical isolates of S. pyogenes of 70 STs. Curves were generated as predicted by G+C content discriminating the 70 STs into 65 distinct MelTs.

Matrix metalloproteinase biosensor based on a porous silicon reflector

Matrix metalloproteinases (MMPs) are proteolytic enzymes important to wound healing. In non-healing wounds, it has been suggested that MMP levels become dysfunctional, hence it is of great interest to develop sensors to detect MMP biomarkers. This study presents the development of a label-free optical MMP biosensor based on a functionalised porous silicon (pSi) thin film. The biosensor is fabricated by immobilising a peptidomimetic MMP inhibitor in the porous layer using hydrosilylation followed by amide coupling. The binding of MMP to the immobilised inhibitor translates into a change of effective optical thickness (EOT) over the time. We investigate the effect of surface functionalisation on the stability of pSi surface and evaluate the sensing performance. We successfully demonstrate MMP detection in buffer solution and human wound fluid at physiologically relevant concentrations. This biosensor may find application as a point-of-care device that is prognostic of the healing trajectory of chronic wounds.

Polarized infrared absorption spectrum of matrix-isolated methylperoxyl radicals, CH3OO (X)over-tilde 2A ''

We have used a tandem pair of supersonic nozzles to produce clean samples of CH3OO radicals in cryogenic matrices. One hyperthermal nozzle decomposes azomethane (CH3NNCH3) to generate intense pulses of CH3 radicals, While the second nozzle alternately fires a burst Of O-2/Ar at the 20 K matrix. The CH3/O-2/20 K argon radical sandwich acts to produce target methylperoxyl radicals: CH3 + O-2 --> CH3OO. The absorption spectra of the radicals are monitored with a Fourier transform infrared spectrometer. We report 10 of the 12 fundamental infrared bands of the methylperoxyl radical CH3OO, (X) over tilde (2)A", in an argon matrix at 20 K. The experimental frequencies (cm(-1)) and polarizations follow: the a' modes are 3032, 2957, 1448, 1410, 1180, 1109, 90, 492, while the a" modes are 3024 and 1434. We cannot detect the asymmetric CH3 rocking mode, nu(11), nor the torsion, nu(12). The infrared spectra of (CH3OO)-O-18-O-18, (CH3OO)-C-13, and CD3OO have been measured as well in order to determine the isotopic shifts. The experimental frequencies, {nu}, for the methylperoxyl radicals are compared to harmonic frequencies, {omega}, resulting from a UB3LYP/6-311G(d,p) electronic structure calculation. Linear dichroism spectra were measured with photooriented radical samples in order to establish the experimental polarizations of most vibrational bands. The methylperoxyl radical matrix frequencies listed above are within +/-2% of the gas-phase vibrational frequencies. A final set of vibrational frequencies for the H radical, are recommended. See also http://ellison.colorado.edu/methylperoxyl.