Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects

Deficits in lentiform nucleus volume and morphometry are implicated in a number of genetically influenced disorders, including Parkinson's disease, schizophrenia, and ADHD. Here we performed genome-wide searches to discover common genetic variants associated with differences in lentiform nucleus volume in human populations. We assessed structural MRI scans of the brain in two large genotyped samples: the Alzheimer's Disease Neuroimaging Initiative (ADNI; N = 706) and the Queensland Twin Imaging Study (QTIM; N = 639). Statistics of association from each cohort were combined meta-analytically using a fixed-effects model to boost power and to reduce the prevalence of false positive findings. We identified a number of associations in and around the flavin-containing monooxygenase (FMO) gene cluster. The most highly associated SNP, rs1795240, was located in the FMO3 gene; after meta-analysis, it showed genome-wide significant evidence of association with lentiform nucleus volume (PMA = 4. 79 × 10-8). This commonly-carried genetic variant accounted for 2. 68 % and 0. 84 % of the trait variability in the ADNI and QTIM samples, respectively, even though the QTIM sample was on average 50 years younger. Pathway enrichment analysis revealed significant contributions of this gene to the cytochrome P450 pathway, which is involved in metabolizing numerous therapeutic drugs for pain, seizures, mania, depression, anxiety, and psychosis. The genetic variants we identified provide replicated, genome-wide significant evidence for the FMO gene cluster's involvement in lentiform nucleus volume differences in human populations.

El Forment a la Barcelona baixmedieval: preus, mesures i fiscalitat (1283-1345)

A través de l'anàlisi de dos sèries de diferents llibres de comptabilitat de Barcelona, els procedents de la gestió dels molins reals i els redactats per una institució eclesiàstica, la Pia Almoina, vam començar a estudiar el mercat del blat a Barcelona durant l'edat mitjana. Hem analitzat anteriorment el valor de les mesures a Barcelona i, per poder qualificar el preu real del pa, també hem estudiat els diferents processos industrials per fer pa de blat. Després, hem analitzat el conjunt d'impostos que pesaven sobre la comercialització de cereals. A través de l'estudi de l'evolució dels preus, hem tractat de fer una primera aproximació de la primera etapa de la crisi baixmedieval, concretament entre 1283 i 1345, tenint en compte els contrastos amb els treballs ja coneguts sobre la base de les fonts on la noció de quantitat no va ser considerada. Finalment, hem comparat els nostres resultats amb alguns treballs referents a la Corona d'Aragó i el món mediterrani, a fi d'obtenir una idea més precisa de la cronologia de les crisis de subsistència

Accounts of the English Crown with Italian merchant societies, 1272-1345

The credit arrangements between the three Edwards and Italian merchants were crucial for financing England’s ambitious foreign policies and ensuring the smooth running of governmental administration. The functioning of this credit system can be followed in detail through the well-kept but mostly unpublished records of the English Exchequer. This volume combines a transcription of the most important surviving accounts between the merchants and the Crown, with a parallel abstract presenting the core data in a double-entry format as credits to or debits from the king's account. This dual format was chosen to facilitate the interpretation of the source while still retaining the language and, as far as possible, the structure of the original documents. The wealth of evidence presented here has much value to add to our understanding of the financing of medieval government and the early development of banking services provided by Italian merchant societies. In particular, although the relationship between king and banker was, for the most part, mutually profitable, the English kings also acquired a reputation for defaulting on their debts and thus 'breaking' a succession of merchant societies. These documents provide an essential basis for a re-examination of the 'credit rating' of the medieval English Crown.

Le credit au Moyen Age: les prets a la couronne D'Angleterre entre 1272 et 1345

A summary of some of the key findings of a recent ESRC-funded project based at the ICMA centre, University of Reading. This study applied modern financial analysis and theories to the early history of sovereign debt, in this case the credit arrangements between the ‘Three Edwards’, kings of England 1272-1377, and a succession of Italian merchant societies.

El discurso de Polinices (vv. 1284-1345) en Edipo en Colono de Sófocles

Edipo en Colono de Sófocles resulta una obra fuertemente argumentativa por los debates dialécticos que se presentan entre los Episodios II a IV, cuya función dramática consiste en demorar el destino de Edipo y, a su vez, desplegar una densidad intratextual muy rica. Easterling (1999: 95-107) afirma que hay tres rasgos que definen el estilo de Sófocles, ellos son, por un lado, la tensión de opuestos o contradicciones; en segundo lugar, la oscilación entre el sentido literal y el sentido metafórico y, por último, la concentración junto con el uso de repeticiones. En el presente estudio analizamos el discurso de Polinices como el ejemplo de las características mencionadas, las que convierten la intervención del joven guerrero en el punto cultimante de las escenas agonales, que constituyen el núcleo de la obra. Estas instancias disonantes que los enfrentamientos producen son atemperadas por la presencia de Teseo.

El discurso de Polinices (vv. 1284-1345) en Edipo en Colono de Sófocles

Edipo en Colono de Sófocles resulta una obra fuertemente argumentativa por los debates dialécticos que se presentan entre los Episodios II a IV, cuya función dramática consiste en demorar el destino de Edipo y, a su vez, desplegar una densidad intratextual muy rica. Easterling (1999: 95-107) afirma que hay tres rasgos que definen el estilo de Sófocles, ellos son, por un lado, la tensión de opuestos o contradicciones; en segundo lugar, la oscilación entre el sentido literal y el sentido metafórico y, por último, la concentración junto con el uso de repeticiones. En el presente estudio analizamos el discurso de Polinices como el ejemplo de las características mencionadas, las que convierten la intervención del joven guerrero en el punto cultimante de las escenas agonales, que constituyen el núcleo de la obra. Estas instancias disonantes que los enfrentamientos producen son atemperadas por la presencia de Teseo.

El discurso de Polinices (vv. 1284-1345) en Edipo en Colono de Sófocles

Edipo en Colono de Sófocles resulta una obra fuertemente argumentativa por los debates dialécticos que se presentan entre los Episodios II a IV, cuya función dramática consiste en demorar el destino de Edipo y, a su vez, desplegar una densidad intratextual muy rica. Easterling (1999: 95-107) afirma que hay tres rasgos que definen el estilo de Sófocles, ellos son, por un lado, la tensión de opuestos o contradicciones; en segundo lugar, la oscilación entre el sentido literal y el sentido metafórico y, por último, la concentración junto con el uso de repeticiones. En el presente estudio analizamos el discurso de Polinices como el ejemplo de las características mencionadas, las que convierten la intervención del joven guerrero en el punto cultimante de las escenas agonales, que constituyen el núcleo de la obra. Estas instancias disonantes que los enfrentamientos producen son atemperadas por la presencia de Teseo.

Amstelredams eer ende opcomen, : door de denckwaerdighe miraklen aldaer gescheid, aen ende door het H. Sacrement des altaers. Anno 1345 /

Head- and tail-pieces; initials.

Thorner denkwürdigkeiten von 1345-1547.

Mode of access: Internet.

Army ammunition data sheets for land mines (FSC 1345).

"February 1977."

A differential kinetic spectrophotometric method for determination of three sulphanilamide artificial sweeteners with the aid of chemometrics

A simple and sensitive spectrophotometric method for the simultaneous determination of acesulfame-K, sodium cyclamate and saccharin sodium sweeteners in foodstuff samples has been researched and developed. This analytical method relies on the different kinetic rates of the analytes in their oxidative reaction with KMnO4 to produce the green manganate product in an alkaline solution. As the kinetic rates of acesulfame-K, sodium cyclamate and saccharin sodium were similar and their kinetic data seriously overlapped, chemometrics methods, such as partial least squares (PLS), principal component regression (PCR) and classical least squares (CLS), were applied to resolve the kinetic data. The results showed that the PLS prediction model performed somewhat better. The proposed method was then applied for the determination of the three sweeteners in foodstuff samples, and the results compared well with those obtained by the reference HPLC method.

Raman spectroscopy of selected borate minerals of the pinakiolite group

The Raman spectra of a series of related minerals of the pinakiolite group of minerals have been collected and the spectra related to the mineral structure. These minerals are based upon an isolated BO33- ion. The site symmetry is reduced from D3h to C1. Intense Raman bands are observed for the minerals takeuchiite, pinakiolite, fredrikssonite and azoproite at 1084, 1086, 1086 and 1086 cm-1. These bands are assigned to the ν1 BO33- symmetric stretching mode. Low intensity Raman bands are observed for the minerals at 1345, 1748; 1435, 1748; 1435, 1750; 1436, 1749 cm-1. One probable assignment is to ν3 BO33- antisymmetric stretching mode. Intense Raman bands of takeuchiite, pinakiolite, fredrikssonite and azoproite at 712 cm-1 attributed to the ν2 out-of-plane bending mode. Importantly, through the comparison of the Raman spectra, the molecular structure of borate minerals with ill-defined structures can be obtained.

The Influence of work motivation on project success : towards a framework

The purpose of this paper is to suggest a framework to study the influence of 'Work motivation' on 'Project success' from a team members' perspective. Results from a literature review of 1345 articles on ' Project success' and 1063 articles of 'Work motivation' appearing in peer-reviewed journals between 1985 and 2005 are presented. We then propose a framework to study the impact of 'Work motivation' on 'Project success' by incorporating the key constructs pertaining to these variables derived from the literature review.