Diário da Constituinte [gravação de vídeo] : [programa n. 132]

Relatores Adjuntos da Comissão de Sistematização cumpriram o prazo e entregaram a revisão final das emendas ao anteprojeto de Constituição ao Presidente da Comissão Afonso Arinos (PFL-RJ). José Ignácio Ferreira (PMDB-ES) explica como foi minuciosa a análise das emendas. O PMDB, o PFL e o PDT fecharam acordo para aprovar o parecer sobre as emendas, sem admissão de destaques. Adolfo Oliveira (PL-RJ) diz que o anteprojeto receberá milhares de contribuições e vai merecer um estudo criterioso por parte do Relator Bernardo Cabral para o preparo de um projeto que some as propostas das comissões temáticas com as do Plenário. Vivaldo Barbosa (PDT-RJ) ressalta que, durante os próximos trinta dias, a sociedade como um todo e os constituintes poderão enviar suas emendas e espera que desse trabalho conjunto se possa produzir uma Constituição capaz de promover a democracia e a justiça social no país. Na sessão O Povo Pergunta, cidadão quer saber como os constituintes estão fazendo para a melhoria dos transportes públicos. Átila Lira (PFL-PI) responde que a Constituição tratará de princípios em relação ao sistema de transporte, como um serviço público de responsabilidade do Estado, podendo ser explorado diretamente ou por concessão à iniciativa privada. A Comissão de Sistematização da Assembleia Nacional Constituinte (ANC) reuniu-se extraordinariamente para votar dois projetos de decisão. O primeiro sobre a dívida externa e o outro sobre a transmissão obrigatória de todas as votações plenárias pelo rádio e televisão. Artur da Távola (PMDB-RJ) não considera que impor ao telespectador a transmissão obrigatória de todas as sessões seja a melhor solução, mas sugere que o tempo do programa Diário da Constituinte possa ser ampliado, de tal forma que seja transmitido o resumo dos trabalhos. Plínio de Arruda Sampaio (PT-SP) defende o projeto de decisão.

MicroRNA-132 is a physiological regulator of hematopoietic stem cell function and B-cell development

MicroRNAs are a class of small non-coding RNAs that negatively regulate gene expression. Several microRNAs have been implicated in altering hematopoietic cell fate decisions. Importantly, deregulation of many microRNAs can lead to deleterious consequences in the hematopoietic system, including the onset of cancer, autoimmunity, or a failure to respond effectively to infection. As such, microRNAs fine-tune the balance between normal hematopoietic output and pathologic consequences. In this work, we explore the role of two microRNAs, miR-132 and miR-125b, in regulating hematopoietic stem cell (HSC) function and B cell development. In particular, we uncover the role of miR-132 in maintaining the appropriate balance between self-renewal, differentiation, and survival in aging HSCs by buffering the expression of a critical transcription factor, FOXO3. By maintain this balance, miR-132 may play a critical role in preventing aging-associated hematopoietic conditions such as autoimmune disease and cancer. We also find that miR-132 plays a critical role in B cell development by targeting a key transcription factor, Sox4, that is responsible for the differentiation of pro-B cells into pre-B cells. We find that miR-132 regulates B cell apoptosis, and by delivering miR-132 to mice that are predisposed to developing B cell cancers, we can inhibit the formation of these cancers and improve the survival of these mice. In addition to miR-132, we uncovered the role of another critical microRNA, miR-125b, that potentiates hematopoietic stem cell function. We found that enforced expression of miR-125b causes an aggressive myeloid leukemia by downregulation of its target Lin28a. Importantly, miR-125b also plays a critical role in inhibiting the formation of pro-B cells. Thus, we have discovered two microRNAs with important roles in regulating normal hematopoiesis, and whose dregulation can lead to deleterious consequences such as cancer in the aging hematopoietic system. Both miR-132 and miR-125b may therefore be targeted for therapeutics to inhibit age-related immune diseases associated with the loss of HSC function and cancer progression.

Holopedium gibberum - an indicator of soft-water lakes? [Translation from: Fauna 21 130-132, 1968.]

In fresh waters the planktonic Crustacea are represented mainly by the two large groups, the Copepoda and the Cladocera. This study focuses on Holopedium gibberum and examines if the plankton is an indicator of soft-water lakes. H. gibberum is found throughout the northern half of the globe but its distribution is scattered and irregular. The study is based on a literature review and samples taken from water bodies in Norway.

Constraints on the symmetry energy and neutron skins from pygmy resonances in Ni-68 and Sn-132

Correlations between the behavior of the nuclear symmetry energy, the neutron skins, and the percentage of energy-weighted sum rule (EWSR) exhausted by the pygmy dipole resonance (PDR) in Ni-68 and Sn-132 are investigated by using different random phase approximation (RPA) models for the dipole response, based on a representative set of Skyrme effective forces plus meson-exchange effective Lagrangians. A comparison with the experimental data has allowed us to constrain the value of the derivative of the symmetry energy at saturation. The neutron skin radius is deduced under this constraint.

Rare earth complexes with Ge-132 and their catalytic hydrolysis to phosphatide bond of mononucleotide

The complexes of a series of rare earths with Ge-132 have been prepared. The carboxyl anions of Ge-132 molecule were coordinated to rare earth ion with chelate style. In the complexes molecule, the GeO3/2 group of Ge-132 were hydrolyzed to become -Ge(OH)(3) group, and later does:not coordinate with rare earth ions. All of the complexes possess similar properties. In aqueous solution of pH 6 and 50 degrees C, these complexes can obviously selectively catalytically hydrolize the phosphatide bond of 5'-AMP and 5'-dAMP into phosphatic acid and riboside.