ACE research vignette 019 : exploring the "Dark Side" of entrepreneurship

This series of research vignettes is aimed at sharing current and interesting research findings from our team of international Entrepreneurhsip researchers. In this vignette, Dr Rene Bakker explores "the dark side" of entrepreneurship.

Teología, 1971, Tomo IX nº 019 (número completo)

Dios se llama Padre / Ricardo Ferrara -- La imagen de Cristo / Ramón Bilbao -- Dios y los valores humanos / Orlando Yorio -- Algunas reflexiones teológico-pastorales acerca de la no creencia práctica / Enrique Küppers -- El misterio de Dios y la situación actual del pensamiento religioso comprendida desde su historia / Juan Carlos Scannone -- Soportes cristológicos en “Gaudium en Spes” / Joaquín Ruiz Escribano

Diário da Constituinte [gravação de vídeo] : [programa n. 019]

O Ministro da Previdência Social Rafael de Almeida Magalhães participa de audiência pública na Subcomissão de Saúde, Seguridade e do Meio Ambiente e defende a mudança de conceito da Previdência Social para Seguridade Social. A Subcomissão da Nacionalidade, da Soberania e das Relações Internacionais recebe em audiência pública, Paulo Tarso Flexa de Lima, Secretário-Geral do Itamaraty, que expõe o papel da chancelaria brasileira nas relações internacionais, da dívida externa e do protecionismo. Roberto D'Ávila (PDT-RJ), Presidente da Subcomissão comenta a importância da presença do secretário do Itamaraty na comissão. Plenário da Assembleia Nacional Constituinte (ANC), presidido por Ulysses Guimarães, vão a tribuna os oradores: O Senador Álvaro Arantes (PC do B-GO) que se solidariza com os professores da rede de ensino pública do DF e critica o Governador José Aparecido de Oliveira; o Deputado Augusto Carvalho (PCB - DF) que em discurso acredita existir um plano para desmantelar e desmoralizar as empresas públicas. O Deputado Francisco Rossi (PTB-SP) defende a pena de morte em casos específicos de extrema violência.

Survival with Newly Diagnosed Metastatic Prostate Cancer in the "Docetaxel Era": Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019)

BACKGROUND Prostate cancer (PCa) is the second most common disease among men worldwide. It is important to know survival outcomes and prognostic factors for this disease. Recruitment for the largest therapeutic randomised controlled trial in PCa-the Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy: A Multi-Stage Multi-Arm Randomised Controlled Trial (STAMPEDE)-includes men with newly diagnosed metastatic PCa who are commencing long-term androgen deprivation therapy (ADT); the control arm provides valuable data for a prospective cohort. OBJECTIVE Describe survival outcomes, along with current treatment standards and factors associated with prognosis, to inform future trial design in this patient group. DESIGN, SETTING, AND PARTICIPANTS STAMPEDE trial control arm comprising men newly diagnosed with M1 disease who were recruited between October 2005 and January 2014. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS Overall survival (OS) and failure-free survival (FFS) were reported by primary disease characteristics using Kaplan-Meier methods. Hazard ratios and 95% confidence intervals (CIs) were derived from multivariate Cox models. RESULTS AND LIMITATIONS A cohort of 917 men with newly diagnosed M1 disease was recruited to the control arm in the specified interval. Median follow-up was 20 mo. Median age at randomisation was 66 yr (interquartile range [IQR]: 61-71), and median prostate-specific antigen level was 112 ng/ml (IQR: 34-373). Most men (n=574; 62%) had bone-only metastases, whereas 237 (26%) had both bone and soft tissue metastases; soft tissue metastasis was found mainly in distant lymph nodes. There were 238 deaths, 202 (85%) from PCa. Median FFS was 11 mo; 2-yr FFS was 29% (95% CI, 25-33). Median OS was 42 mo; 2-yr OS was 72% (95% CI, 68-76). Survival time was influenced by performance status, age, Gleason score, and metastases distribution. Median survival after FFS event was 22 mo. Trial eligibility criteria meant men were younger and fitter than general PCa population. CONCLUSIONS Survival remains disappointing in men presenting with M1 disease who are started on only long-term ADT, despite active treatments being available at first failure of ADT. Importantly, men with M1 disease now spend the majority of their remaining life in a state of castration-resistant relapse. PATIENT SUMMARY Results from this control arm cohort found survival is relatively short and highly influenced by patient age, fitness, and where prostate cancer has spread in the body.