Neogene calcareous nannofossils in ODP Leg 116 holes

The three sites (717, 718, and 719) drilled on the distal Bengal Fan during ODP Leg 116 cored turbidite sediments almost exclusively. Calcareous nannofossils were recovered sporadically and, although all of them probably have been redeposited, it is possible to date the sediments at all three sites with reasonable confidence. Site 717 penetrated the uppermost middle Miocene Catinaster coalitus highest occurrence datum and represents the most nearly continuous succession of turbidites. Site 718 penetrated the lower Miocene, well below the Helicosphaera ampliaperta highest occurrence datum, but this site contains a major late Pliocene to mid-Pleistocene hiatus. Site 719, the shallowest hole, penetrated only into the upper Miocene. Identification of several critical lowest occurrence datums allows using the poorly constrained but more numerous highest occurrence datums for comparison with the model succession (zonal markers) and thereby to derive a reasonably accurate time framework for the sediments.

Sedimentary history and chemical characteristics of clay minerals from the Bengal Fan

The purpose of this study is to clarify the sedimentary history and chemical characteristics of clay minerals found in sediments deposited in the distal part of the Bengal Fan since the Himalayas were uplifted 17 m.y. ago. A total of seventy-eight samples were collected from three drilled cores which were to be used for the clay mineral analyses by means of XRD and ATEM. The results obtained from the analyses show that individual clay mineral species in the sediment samples at each site have similar features when the samples are of the same age, whereas these species have different features in samples of differing geological ages. Detrital clay minerals such as illite and chlorite were deposited in greater amounts than kaolinite and smectite during the Early to Middle Miocene. This means that the Himalayan uplift was vigorous at least until the Middle Miocene. In the Pliocene chemical weathering was more prevalent so that instead, in the distal part of the Bengal Fan, kaolinite shows the highest concentrations. This would accord with weaker uplift in the Himalayas. In the Pleistocene period, vigorous Himalayan uplift is characterized by illite-rich sediment in place of kaolinite. In the Holocene, smectite shows the highest concentration in place of the illite and kaolinite which were the predominant clay minerals of the earlier periods. Increasing smectite concentration suggests the Himalayan uplift to have been stable after the Pleistocene period. The smectite analyzed here is found to be dioctahedral Fe-beidellite, and it originated largely from the augite-basalt on the Indian Deccan Traps. The tri-octahedral chlorite is subdivided into three sub-species, an Fe-type, a Mg-type and an intermediate type. The mica clay mineral can be identified as di-octahedral illite which is rich in potassium. The chemical composition and morphology of each clay mineral appears to exhibit no change with burial depth in the sedimentary columns. This implies that there was no systematic transformation of clay minerals with time.

Carbonate cements and fluid circulation of ODP Leg 116 samples

The carbonate cements found in Sites 717-719 of ODP Leg 116 correspond to the precipitation of inorganic calcite due to circulation of hot fluid associated with intraplate deformation in the central Indian Ocean. A first burst of hydrothermal activity may have occurred 7.5-9 Ma and a second burst less than 0.5 Ma. These fluids were probably derived from the basaltic basement and the immediately overlying sediments.

Grain size analyses of ODP Leg 116 holes

Ocean Drilling Program (ODP) Leg 116 cored the distal part of the Bengal Fan at three closely spaced sites (717-719). The recovered sediments consisted dominantly of turbidites that varied in thickness between a few centimeters and 2 m or more. A number of different facies have been identified in the sequence and are described by Stow et al. (1990, doi:10.2973/odp.proc.sr.116.110.1990). Representative examples of these facies types were selected and sampled for grain-size analysis. The results of these analyses are tabulated in this data report.

Benthic foraminifera of ODP Leg 116 holes

Benthic foraminifers were examined from turbiditic sequences at Sites 717, 718, and 719. Three assemblages, 1, 2, 3, were identified and are interpreted as reflecting different bathymetric environments. Based on the distribution patterns of these assemblages, six paleontological intervals (a to f) were distinguished and correlated to the lithostratigraphic units and calcareous nannofossil biostratigraphy and biochronology. This relationship indicated three signals of climatic deterioration, the first in the late Pliocene (around 2.42 Ma) and two others in the Pleistocene (younger than 1.59 Ma and 0.93 Ma).

Bioavailability study of oral and intravenous OGT 719, a novel nucleoside analogue with preferential activity in the liver

Purpose: Although oral fluoropyrimidine pro-drugs are increasingly being administered in preference to intravenous nucleoside analogues in cancer chemotherapy, their activation in malignant liver tissue may be insufficient. OGT 719 (1-galactopyranosyl-5-fluorouracil) is a novel nucleoside analogue, preferentially localized in hepatocytes and hepatoma cells via the asialoglycoprotein receptor. The aim of this study was to assess the systemic bioavailability of this rationally designed drug in 16 patients with advanced solid cancers. Method: Crossover pharmacokinetic study of oral (400 or 800 mg) and intravenous (250 mg/m 2) OGT 719. Results: Linear pharmacokinetics and oral bioavailability of approximately 25% were observed at the dose levels used in this study. Like other 5-FU prodrugs, considerable interpatient variability was observed in bioavailability following oral dosing. The mean half-life for oral doses was 4 h. OGT 719 was well tolerated. No objective tumour responses were demonstrated. Conclusion: The systemic bioavailability and half-life of oral OGT 719 are sufficient to merit dose escalation studies with frequent daily dosing. Subsequent efficacy studies should be performed in patients with primary and secondary liver malignancies.

Bioavailability study of oral and intravenous OGT 719, a novel nucleoside analogue with preferential activity in the liver

Purpose: Although oral fluoropyrimidine pro-drugs are increasingly being administered in preference to intravenous nucleoside analogues in cancer chemotherapy, their activation in malignant liver tissue may be insufficient. OGT 719 (1-galactopyranosyl-5-fluorouracil) is a novel nucleoside analogue, preferentially localized in hepatocytes and hepatoma cells via the asialoglycoprotein receptor. The aim of this study was to assess the systemic bioavailability of this rationally designed drug in 16 patients with advanced solid cancers. Method: Crossover pharmacokinetic study of oral (400 or 800 mg) and intravenous (250 mg/m 2) OGT 719. Results: Linear pharmacokinetics and oral bioavailability of approximately 25% were observed at the dose levels used in this study. Like other 5-FU prodrugs, considerable interpatient variability was observed in bioavailability following oral dosing. The mean half-life for oral doses was 4 h. OGT 719 was well tolerated. No objective tumour responses were demonstrated. Conclusion: The systemic bioavailability and half-life of oral OGT 719 are sufficient to merit dose escalation studies with frequent daily dosing. Subsequent efficacy studies should be performed in patients with primary and secondary liver malignancies.