Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 1159 - Zum Streit zwischen Professor Böck und den Homöopathen

u.a. Besuch von Fedor Stauwe;

Ms. Ff. Mus. 1159 - Jubilate

[Georg Philipp Telemann]. [Text: Gottfried Simonis]

Batalla de Putaha 1159 [Material gráfico]

Resumen: Descripción: hombres a caballo luchando con sus lanzas y espadas

Aircraft accident report : International Business Machines, inc., Grumman G-1159, N720Q, Kline, South Carolina, June 24, 1974 /

"File no. 3-1400."

Organizational, direct support, and general support maintenance repair parts and special tools list (including depot maintenance repair parts and special tools) for dual time base plug-in unit TD-1159/U (NSN 6625-00-261-5139).

"9 October 1982."

Operator, organizational, direct and general support and depot maintenance manual : air conditioner, floor mounting, air cooled, 6 HP, AC 208/416 V, 3 phase, 60 cycle, 60,000 BTU (Keco model F-60), FSN 4120-926-1159.

"December 1967."

Organizational, direct and general support, and depot maintenance repair parts and special tools list : air conditioner, floor mounted, air cooled, 6 hp, AC, 208/416V, 3 phase, 60 cycle, 60,000 Btu/hr (Keco model F-60), FSN 4120-926-1159.

"September 1968."

Operator, organizational, direct support, general support, and depot maintenance manual including repair parts and special tool lists : filter kit, infrared, MK-1159/PAS-5.

"May 1969."

Inactivation Of Ampk Mediates High Phosphate-induced Extracellular Matrix Accumulation Via Nox4/tgfß-1 Signaling In Human Mesangial Cells.

High phosphate (Pi) levels and extracellular matrix (ECM) accumulation are associated with chronic kidney disease progression. However, how high Pi levels contribute to ECM accumulation in mesangial cells is unknown. The present study investigated the role and mechanism of high Pi levels in ECM accumulation in immortalized human mesangial cells (iHMCs). iHMCs were exposed to normal (0.9 mM) or increasing Pi concentrations (2.5 and 5 mM) with or without diferent blockers or activators. NOX4, phosphorylated AMPK (p-AMPK), phosphorylated SMAD3 (p-SMAD3), fibronectin (F/N), collagen IV (C-IV) and alpha-smooth muscle actin (α-SMA) expression was assessed via western blot and immunofluorescence. Lucigenin-enhanced chemiluminescence, and dihydroethidium (DHE) assessed NADPH oxidase activity and superoxide (SO), respectively. In iHMCs, a Pi transporter blocker (PFA) abrogated high Pi-induced AMPK inactivation, increase in NADPH oxidase-induced reactive oxygen species (ROS) levels, NOX4, p-SMAD3, α-SMA and C-IV expression. AMPK activation by AICAR, NOX4 silencing or NADPH oxidase blocker prevented high Pi-induced DHE levels, p-SMAD3, F/N, C-IV and α-SMA expression. AMPK inactivation with NOX4-induced ROS formation and transforming growth factor ß-1 (TGFß-1) signaling activation mediates high Pi-induced ECM accumulation in iHMCs. Maneuvers increasing AMPK or reducing NOX4 activity may contribute to renal protection under hyperphosphatemia.