Foucault goes to the footy: professionalism, performance, prudentialism and playstations in the life of AFL footballers

This paper will report on a research project funded by the Australian Football League (AFL) that is exploring the emergence and evolution of a ‘professional identity’ for AFL footballers – an identity that has many facets including the emerging ideas that a professional leads a balanced life, and has a prudent orientation to the future. The research is informed by Foucault’s later work on the care of the Self to focus on the ways in which player identities are governed by coaches, club officials, player agents and the AFL Commission/Executive; and the manner in which players conduct themselves in ways that can be characterised as professional - or not. The paper explores elements of these processes by analysing the forms of risk management that Clubs use in the processes of List and Player management that they engage in as a consequence of AFL rules. Psychological testing and profiling of players is becoming more important in identifying, recruiting and managing players. The paper discusses how this testing is used to identify character or personality traits prior to initial recruitment in the draft or trading processes – and suggests that a number of issues related to workplace surveillance and identity emerge as a result.

Enhancing web-based adaptive learning with colored timed petri net

One of the issues for Web-based learning applications is to adaptively provide personalized instructions for different learning activities. This paper proposes a high level colored timed Petri Net based approach to providing some level of adaptation for different users and learning activities. Examples are given to demonstrate how to realize adaptive interfaces and personalization. Future directions are also discussed at the end of this paper.

Natural and environmentally responsive building envelopes

In a context of global warming and our needs to reduce CO\d2 emissions, building envelopes will play an important role. A new imperative has been put forth to architects and engineers to develop innovative materials, components and systems, in order to make building envelopes adaptive and responsive to variable and extreme climate conditions. Envelopes serve multiple functions, from shielding the interior environment to collecting, storing and generating energy. Perhaps a more recent concern of terrestrial habitats is permeability and leakages within the building envelope. Such airtight and concealed envelopes with zero particle exchange are a necessity and already exist in regard to space capsules and habitats.

This paper attempts to acknowledge existing and visionary envelope concepts and their functioning in conjunction with maintaining a favorable interior environment. It introduces several criteria and requirements of advanced fa\acades along with interior pressurization control. Furthermore, the paper also takes a closer look at the principles of "biomimicry" of natural systems combined with the most up-to-date building materials and construction technologies, trying to integrate the notions of adaptation - where the capacity to survive depends on the ability to adjust to the environment - within the concept of technological evolution and innovation. An "adaptive" attitude in the way in which we conceive our built structures provides a conceptual basis for the advanced building design of our future, as well as one concerned about the efficient management of the available resources. Built environments of the future (in extreme climates or not) will need to respond to Renewable, Adaptive, Recyclable and Environmental (R.A.R.E.) concepts in order to coexist in a sustainable way with their surroundings.

Metabolism and transport of oxazphosphorines and the clinical implications

The oxazaphosphorines including cyclophosphamide (CPA), ifosfamide (IFO), and trofosfamide represent an important group of therapeutic agents due to their substantial antitumor and immuno-modulating activity. CPA is widely used as an anticancer drug, an immunosuppressant, and for the mobilization of hematopoetic progenitor cells from the bone marrow into peripheral blood prior to bone marrow transplantation for aplastic anemia, leukemia, and other malignancies. New oxazaphosphorines derivatives have been developed in an attempt to improve selectivity and response with reduced toxicity. These derivatives include mafosfamide (NSC 345842), glufosfamide (D19575, β-D-glucosylisophosphoramide mustard), NSC 612567 (aldophosphamide perhydrothiazine), and NSC 613060 (aldophosphamide thiazolidine). This review highlights the metabolism and transport of these oxazaphosphorines (mainly CPA and IFO, as these two oxazaphosphorine drugs are the most widely used alkylating agents) and the clinical implications. Both CPA and IFO are prodrugs that require activation by hepatic cytochrome P450 (CYP)-catalyzed 4-hydroxylation, yielding cytotoxic nitrogen mustards capable of reacting with DNA molecules to form crosslinks and lead to cell apoptosis and/or necrosis. Such prodrug activation can be enhanced within tumor cells by the CYP-based gene directed-enzyme prodrug therapy (GDEPT) approach. However, those newly synthesized oxazaphosphorine derivatives such as glufosfamide, NSC 612567 and NSC 613060, do not need hepatic activation. They are activated through other enzymatic and/or non-enzymatic pathways. For example, both NSC 612567 and NSC 613060 can be activated by plain phosphodiesterase (PDEs) in plasma and other tissues or by the high-affinity nuclear 3'-5' exonucleases associated with DNA polymerases, such as DNA polymerases and ε. The alternative CYP-catalyzed inactivation pathway by N-dechloroethylation generates the neurotoxic and nephrotoxic byproduct chloroacetaldehyde (CAA). Various aldehyde dehydrogenases (ALDHs) and glutathione S-transferases (GSTs) are involved in the detoxification of oxazaphosphorine metabolites. The metabolism of oxazaphosphorines is auto-inducible, with the activation of the orphan nuclear receptor pregnane X receptor (PXR) being the major mechanism. Oxazaphosphorine metabolism is affected by a number of factors associated with the drugs (e.g., dosage, route of administration, chirality, and drug combination) and patients (e.g., age, gender, renal and hepatic function). Several drug transporters, such as breast cancer resistance protein (BCRP), multidrug resistance associated proteins (MRP1, MRP2, and MRP4) are involved in the active uptake and efflux of parental oxazaphosphorines, their cytotoxic mustards and conjugates in hepatocytes and tumor cells. Oxazaphosphorine metabolism and transport have a major impact on pharmacokinetic variability, pharmacokinetic-pharmacodynamic relationship, toxicity, resistance, and drug interactions since the drug-metabolizing enzymes and drug transporters involved are key determinants of the pharmacokinetics and pharmacodynamics of oxazaphosphorines. A better understanding of the factors that affect the metabolism and transport of oxazaphosphorines is important for their optional use in cancer chemotherapy.

A platform for dynamic organization of agents in agent-based systems

In most agent-based systems, different middle agents are employed to increase their flexibility. However, there are still three issues remain unsolved. In centralized architecture with single middle agent, the middle agent itself is a bottleneck and suffers from single point failure; middle agents in distributed architecture lack capability of dynamic organization of agents; The reliability is not strong because of the single point failure and lack of effective architecture. We introduce a platform with ring architectural model to solve all above problems. In the platform, multiple middle agents are dynamically supported for solving the first problem. For solving the second problem, middle agents dynamically manage the registration and cancellation of service provider agents and application teams, each of which includes a set of closely interacting requester agents to complete an independent task. Redundancy middle agent technique is proposed for solving the third problem. All middle agents are of the feature of proliferation and self-cancellation according to the sensory inputs from their environment. For organizing the middle agents effectively, a ring architectural model is proposed. We demonstrate the applicability of the platform by its application and present experimental evidence that the platform is flexible and robust.

Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development

Human contains 49 ATP-binding cassette (ABC) transporter genes and the multidrug resistance associated proteins (MRP1/ABCC1, MRP2/ABCC2, MRP3/ABCC3, MRP4/ABCC4, MRP5/ABCC5, MRP6/ABCC6, MRP7/ABCC10, MRP8/ABCC11 and MRP9/ABCC12) belong to the ABCC family which contains 13 members. ABCC7 is cystic fibrosis transmembrane conductance regulator; ABCC8 and ABCC9 are the sulfonylurea receptors which constitute the ATP-sensing subunits of a complex potassium channel. MRP10/ABCC13 is clearly a pseudo-gene which encodes a truncated protein that is highly expressed in fetal human liver with the highest similarity to MRP2/ABCC2 but without transporting activity. These transporters are localized to the apical and/or basolateral membrane of the hepatocytes, enterocytes, renal proximal tubule cells and endothelial cells of the blood-brain barrier. MRP/ABCC members transport a structurally diverse array of important endogenous substances and xenobiotics and their metabolites (in particular conjugates) with different substrate specificity and transport kinetics. The human MRP/ABCC transporters except MRP9/ABCC12 are all able to transport organic anions, such as drugs conjugated to glutathione, sulphate or glucuronate. In addition, selected MRP/ABCC members may transport a variety of endogenous compounds, such as leukotriene C(4) (LTC(4) by MRP1/ABCC1), bilirubin glucuronides (MRP2/ABCC2, and MRP3/ABCC3), prostaglandins E1 and E2 (MRP4/ABCC4), cGMP (MRP4/ABCC4, MRP5/ABCC5, and MRP8/ABCC11), and several glucuronosyl-, or sulfatidyl steroids. In vitro, the MRP/ABCC transporters can collectively confer resistance to natural product anticancer drugs and their conjugated metabolites, platinum compounds, folate antimetabolites, nucleoside and nucleotide analogs, arsenical and antimonial oxyanions, peptide-based agents, and in concert with alterations in phase II conjugating or biosynthetic enzymes, classical alkylating agents, alkylating agents. Several MRP/ABCC members (MRPs 1-3) are associated with tumor resistance which is often caused by an increased efflux and decreased intracellular accumulation of natural product anticancer drugs and other anticancer agents. Drug targeting of these transporters to overcome MRP/ABCC-mediated multidrug resistance may play a role in cancer chemotherapy. Most MRP/ABCC transporters are subject to inhibition by a variety of compounds. Based on currently available preclinical and limited clinical data, it can be expected that modulation of MRP members may represent a useful approach in the management of anticancer and antimicrobial drug resistance and possibly of inflammatory diseases and other diseases. A better understanding of their substrates and inhibitors has important implications in development of drugs for treatment of cancer and inflammation.

Modelling financial investment planning from agent perspectives

Multi-agent Systems (MASs) offer strong models for representing complex and dynamic real-world environments. Taking financial investment planning as an example, this paper describes how to model complex systems from agent perspectives. Different agents and their behaviours are identified for financial investment planning. These agents are put together as an agent-based system. The experimental results show that all agents in the system can work cooperatively to provide reasonable investment advice. The system is very flexible and robust. The success of the system indicates that (MASs) can significantly facilitate the modelling of complex systems.

Agency theory and accounting research : an overview of some conceptual and empirical issues

This chapter aims to give the reader an overview of agency theory (AT) and its application in accounting research. It delineates the basic assumptions and concepts of AT and identifies the various measures that can be undertaken to minimise agency costs. The chapter also provides a summary of the commonalities and differences across the three major paradigms adopted by accounting researches when using an agency framework: Principal-Agent, Transaction Cost Economics and Positivist (Rochester) model. Further, a review of some recent theoretical and empirical studies on the design of optimal contracts, namely those relating to implicit contracts, multi-agents and multi-period issues is undertaken. Several suggestions are made for future studies adopting an AT-based approach.

Hypothesis generation for management intelligence

Investigation of the role of hypothesis formation in complex (business) problem solving has resulted in a new approach to hypothesis generation. A prototypical hypothesis generation paradigm for management intelligence has been developed, reflecting a widespread need to support management in such areas as fraud detection and intelligent decision analysis. This dissertation presents this new paradigm and its application to goal directed problem solving methodologies, including case based reasoning. The hypothesis generation model, which is supported by a dynamic hypothesis space, consists of three components, namely, Anomaly Detection, Abductive Reasoning, and Conflict Resolution models. Anomaly detection activates the hypothesis generation model by scanning anomalous data and relations in its working environment. The respective heuristics are activated by initial indications of anomalous behaviour based on evidence from historical patterns, linkages with other cases, inconsistencies, etc. Abductive reasoning, as implemented in this paradigm, is based on joining conceptual graphs, and provides an inference process that can incorporate a new observation into a world model by determining what assumptions should be added to the world, so that it can explain new observations. Abductive inference is a weak mechanism for generating explanation and hypothesis. Although a practical conclusion cannot be guaranteed, the cues provided by the inference are very beneficial. Conflict resolution is crucial for the evaluation of explanations, especially those generated by a weak (abduction) mechanism.The measurements developed in this research for explanation and hypothesis provide an indirect way of estimating the ‘quality’ of an explanation for given evidence. Such methods are realistic for complex domains such as fraud detection, where the prevailing hypothesis may not always be relevant to the new evidence. In order to survive in rapidly changing environments, it is necessary to bridge the gap that exists between the system’s view of the world and reality.Our research has demonstrated the value of Case-Based Interaction, which utilises an hypothesis structure for the representation of relevant planning and strategic knowledge. Under, the guidance of case based interaction, users are active agents empowered by system knowledge, and the system acquires its auxiliary information/knowledge from this external source. Case studies using the new paradigm and drawn from the insurance industry have attracted wide interest. A prototypical system of fraud detection for motor vehicle insurance based on an hypothesis guided problem solving mechanism is now under commercial development. The initial feedback from claims managers is promising.

Ecology of Pittosporum undulatum Vent. (Pittosporaceae) an environmental weed in south east Australia

Pittosporum undulatum Vent. (Sweet Pittosporum) is a densely foliaged tall shrub or small tree, native to the wet forests of south east Australia, This species now functions as a serious environmental weed in a range of habitats in Australia and on other continents and islands throughout the temperate, sub-tropical and tropical zones. This study investigated some of the ecological causes and consequences of P. undulatum invasion across a range of habitat types in south east Australia. Key aspects of P. undulatum biology and ecology investigated in the current study include; patterns of morphological variation across the range of habitats occupied (as a measure of the species’ plasticity), dispersal ecology and seed germinability, population structure and spatial pattern, community relationships and the ecological impacts of invasion. Phenotypic plasticity is considerable in P. undulatum. No clear patterns of geographic variation emerged from a study of leaf morphological attributes across the current range of this species on mainland south east Australia. The pattern of morphological variation is particularly complex in Victoria, where the invasion of this species is most advanced. The species’ adaptability to a range of environments and environmental conditions will likely promote further range expansion. The abundant winter fruit crop produced by functionally female P. undulatum plants attracts a suite of generalist opportunistic frugivores, which feed on P. undulatum fruits and seeds at various stages of fruit dehiscence, thereby enhancing dispersal opportunities for this species. P. undulatum seed collected from natural and invasive populations, at two stages of fruit maturity and from the scats and pellets of dispersal agents, displayed high germinability. European Blackbirds and Pied Currawongs are implicated as the main avian dispersal agents of P undulatum in south east Australia. The broader ecological implications of developing relationships between invasive fleshy-fruited bird-dispersed plant species and adaptive frugivores are likely to be considerable. The distribution of P. undulatutn seedlings was significantly negatively correlated with adult conspecifics and significantly positively correlated with trees and shrubs of other genera. This pattern reflects the importance of both firugivorous dispersal agents and the species’ germination and establishment requirements, in shaping the contagious distribution pattern typical of this species. These analyses suggest that recruitment opportunities for conspecific seedlings are limited beneath the canopy of adult conspecifics. Densities of P. undulatum were on average, 2.7 times higher in invaded populations, compared to the natural populations sampled. A male-bias was evident in all populations and no relationships between reproductive activity and the density of seedlings and juveniles were evident. Invading populations of P. undulatum impose substantial changes on ecosystem-level properties and functions. Mean species richness and cover-abundance declined notably once P. undulatum cover-abundance exceeded 20% at the invaded sites and 60% at the natural sites sampled. The natural communities sampled displayed comparatively greater resilience to the competitive effects of P. undulatum, but community attributes were affected at high densities and cover-abundance of this species. The cover-abundance of herbs and grasses declined most substantially with increasing P. undulatum at invaded sites, whereas, at the natural sites sampled, the species’ structural analogues appeared to be most affected by increasing P. undulatum cover-abundance. This study has demonstrated that the ecological consequences of P. undulatum population expansion are substantial and contribute to changes in the composition and successional trajectory of affected communities. These processes ultimately lead to the loss and simplification of biodiversity values and the homogenisation of affected habitats. P. undulatum has the potential to emerge as one of south east Australia's most serious environmental weed species.

Agent-based hybrid framework for decision making on complex problems

Electronic commerce and the Internet have created demand for automated systems that can make complex decisions utilizing information from multiple sources. Because the information is uncertain, dynamic, distributed, and heterogeneous in nature, these systems require a great diversity of intelligent techniques including expert systems, fuzzy logic, neural networks, and genetic algorithms. However, in complex decision making, many different components or sub-tasks are involved, each of which requires different types of processing. Thus multiple such techniques are required resulting in systems called hybrid intelligent systems. That is, hybrid solutions are crucial for complex problem solving and decision making. There is a growing demand for these systems in many areas including financial investment planning, engineering design, medical diagnosis, and cognitive simulation. However, the design and development of these systems is difficult because they have a large number of parts or components that have many interactions. From a multi-agent perspective, agents in multi-agent systems (MAS) are autonomous and can engage in flexible, high-level interactions. MASs are good at complex, dynamic interactions. Thus a multi-agent perspective is suitable for modeling, design, and construction of hybrid intelligent systems. The aim of this thesis is to develop an agent-based framework for constructing hybrid intelligent systems which are mainly used for complex problem solving and decision making. Existing software development techniques (typically, object-oriented) are inadequate for modeling agent-based hybrid intelligent systems. There is a fundamental mismatch between the concepts used by object-oriented developers and the agent-oriented view. Although there are some agent-oriented methodologies such as the Gaia methodology, there is still no specifically tailored methodology available for analyzing and designing agent-based hybrid intelligent systems. To this end, a methodology is proposed, which is specifically tailored to the analysis and design of agent-based hybrid intelligent systems. The methodology consists of six models - role model, interaction model, agent model, skill model, knowledge model, and organizational model. This methodology differs from other agent-oriented methodologies in its skill and knowledge models. As good decisions and problem solutions are mainly based on adequate information, rich knowledge, and appropriate skills to use knowledge and information, these two models are of paramount importance in modeling complex problem solving and decision making. Follow the methodology, an agent-based framework for hybrid intelligent system construction used in complex problem solving and decision making was developed. The framework has several crucial characteristics that differentiate this research from others. Four important issues relating to the framework are also investigated. These cover the building of an ontology for financial investment, matchmaking in middle agents, reasoning in problem solving and decision making, and decision aggregation in MASs. The thesis demonstrates how to build a domain-specific ontology and how to access it in a MAS by building a financial ontology. It is argued that the practical performance of service provider agents has a significant impact on the matchmaking outcomes of middle agents. It is proposed to consider service provider agents' track records in matchmaking. A way to provide initial values for the track records of service provider agents is also suggested. The concept of ‘reasoning with multimedia information’ is introduced, and reasoning with still image information using symbolic projection theory is proposed. How to choose suitable aggregation operations is demonstrated through financial investment application and three approaches are proposed - the stationary agent approach, the token-passing approach, and the mobile agent approach to implementing decision aggregation in MASs. Based on the framework, a prototype was built and applied to financial investment planning. This prototype consists of one serving agent, one interface agent, one decision aggregation agent, one planning agent, four decision making agents, and five service provider agents. Experiments were conducted on the prototype. The experimental results show the framework is flexible, robust, and fully workable. All agents derived from the methodology exhibit their behaviors correctly as specified.

Aspergillus species, cyclic dimeric dipeptide derivative substance P antagonist biosynthetic products thereof, and process for preparation thereof

A novel Aspergillus species, cyclic dimeric dipeptide derivatives which are biosynthetic products thereof and are useful as Substance P antagonists and therefore as analgesic and/or antiinflammatory agents, and a process for preparation of the biosynthetic products are disclosed.

Conceptualising, conducting and disseminating research for the 'public'

Drawing upon one research project Home-School-Community Partnerships for Enhancing Children's Numeracy Development we examine, critically, some problems entailed in the processes of conceptualizing the subjects and objects of inquiry, conducting field work with subjects (as knowing agents) and interpreting and disseminating the knowledge gained. Addressing these issues, in practice, has entailed some necessary consideration of fundamental tensions centred around the professional power-knowledge of teachers and a dominant cultural discourse that situates numeracy learning in the school.

A theoretical model (based upon Engeström's Activity Theory) was used to specify and analyse various types of partnerships within a network of mutually interconnected activities to support children's learning (Bloome et al., 2000; Engeström, 1999). By decentering the school, within this model, we have been led to a closer analysis of the concept of 'partnership' and of the social construction of parental and community involvement in children's numeracy development. One of the most problematic aspects of partnerships evident in our research is the way in which the term 'numeracy' is understood by different stakeholders. Awareness of this has shaped the conduct and dissemination of our research and ultimately enabled us to identify critical issues for further inquiry.

Influence of age and DNA damage on expression of damage-processing genes

The effect of DNA damaging agents and age on expression of damage-processing genes was examined in plants and mice. Treatment with these agents increased expression of some genes. The effect of gene expression in the absence of treatment decreased with age, suggesting links between ageing and genetic instability.

Individual differences in affective responses to violence and sexual violence

The thesis aimed to identify and compare individual differences in anger related affective responses upon exposure to neutral, violent and sexually violent film. The findings revealed that both graphic and non-graphic sexually violent film content may have a stronger impact on viewers' anger levels than exposure to standard violent film. The portfolio examined in four case studies the utility of the Violence Risk Scale when seeking to identify factors associated with risk of violent recidivism and subsequent treatment targets for intellectually disabled offenders . Treatment indications must consider the impaired cognitive and adaptive abilities and the difficulties inherent in modifying the behavioural characteristics of intellectually disabled offenders.