New players driving inflammation in monogenic autoinflammatory diseases.

Systemic autoinflammatory diseases are caused by abnormal activation of the cells that mediate innate immunity. In the past two decades, single-gene defects in different pathways, driving clinically distinct autoinflammatory syndromes, have been identified. Studies of these aberrant pathways have substantially advanced understanding of the cellular mechanisms that contribute to mounting effective and balanced innate immune responses. For example, mutations affecting the function of cytosolic immune sensors known as inflammasomes and the IL-1 signalling pathway can trigger excessive inflammation. A surge in discovery of new genes associated with autoinflammation has pointed to other mechanisms of disease linking innate immune responses to a number of basic cellular pathways, such as maintenance of protein homeostasis (proteostasis), protein misfolding and clearance, endoplasmic reticulum stress and mitochondrial stress, metabolic stress, autophagy and abnormalities in differentiation and development of myeloid cells. Although the spectrum of autoinflammatory diseases has been steadily expanding, a substantial number of patients remain undiagnosed. Next-generation sequencing technologies will be instrumental in finding disease-causing mutations in as yet uncharacterized diseases. As more patients are reported to have clinical features of autoinflammation and immunodeficiency or autoimmunity, the complex interactions between the innate and adaptive immune systems are unveiled.

Gobert [André H., joueur de tennis français aux qualificatifs des Jeux interalliés, à la Croix-Catelan, le 1er juin 1919] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54163

Gobert [André H., joueur de tennis français aux qualificatifs des Jeux interalliés à la Croix-Catelan, le 1er juin 1919] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54162

[Karel] Kozeluh, [Watson] Wasburn [i. e. Washburn, joueurs de tennis aux éliminatoires des Jeux interalliés] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54241

Melle Lenglen championne du monde de tennis photographiée après sa victoire [à Londres] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54785

Melle [Suzanne] Lenglen, championne du monde de tennis [gagnante de Wimbledon, le samedi 5 juillet 1919] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54732

[Pat O']Hara-Wood [joueur de tennis australien aux éliminatoires des Jeux interalliés] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54239

[Karel] Kozeluh [joueur de tennis aux éliminatoires des Jeux interalliés] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54243

Matthey [i. e. Dean Mathey, joueur américain de tennis aux éliminatoires des Jeux interalliés] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54242

[Watson] Washburn [joueur de tennis américain aux éliminatoires des Jeux interalliés] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54240

Cannes 21-1-20, Miss Ryan [Elisabeth] et Ritchie [Josiah] [contre] Mlle Lenglen [Suzanne] et Albarran [Pierre] [tournoi de lawn-tennis du Carlton-Club de Cannes] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57735

Steroid profiles of professional soccer players: an international comparative study.

BACKGROUND AND OBJECTIVES: Urinary steroid profiling is used in doping controls to detect testosterone abuse. A testosterone over epitestosterone (T/E) ratio exceeding 4.0 is considered as suspicious of testosterone administration, irrespectively of individual heterogeneous factors such as the athlete's ethnicity. A deletion polymorphism in the UGT2B17 gene was demonstrated to account for a significant part of the interindividual variability in the T/E between Caucasians and Asians. Here, the variability of urinary steroid profiles was examined in a widely heterogeneous cohort of professional soccer players. Method: The steroid profile of 57 Africans, 32 Asians, 50 Caucasians and 32 Hispanics was determined by gas chromatography-mass spectrometry. RESULTS: Significant differences have been observed between all ethnic groups. After estimation of the prevalence of the UGT2B17 deletion/deletion genotype (African: 22%; Asian: 81%; Caucasian: 10%; Hispanic: 7%), ethnic-specific thresholds were developed for a specificity of 99% for the T/E (African: 5.6; Asian: 3.8; Caucasian: 5.7; Hispanic: 5.8). Finally, another polymorphism could be hypothesised in Asians based on specific concentration ratio of 5alpha-/5beta-androstane-3alpha,17beta-diol in urine. CONCLUSION: These results demonstrate that a unique and non-specific threshold to evidence testosterone misuse is not fit for purpose. An athlete's endocrinological passport consisting of a longitudinal follow-up together with the ethnicity and/or the genotype would strongly enhance the detection of testosterone abuse. Finally, additional genotyping studies should be undertaken to determine whether the remaining unexplained disparities have an environmental or a genetic origin.

Cannes, 21-1-20, prince Philippe de Bourbon [jouant au tennis] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57740

Cannes 21-1-20, lord Rochsavage [i. e. marquis de Cholmondeley au tournoi de lawn-tennis du Carlton-Club de Cannes] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57737