Influência da ovariectomia associada à dieta deficiente em cálcio na periodontite experimental

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Maturação nuclear e citoplasmática de oócitos de cadelas colhidos em diferentes fases do ciclo estral e cultivados in vitro em meios sequenciais com hormônios e espermatozóides

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Efeitos do laser e da terapia fotodinâmica no tratamento periodontal mecânico em ratas ovariectomizadas e sob influência sistêmica de nicotina: estudo histomorfométrico e imunoistoquímico

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Efeito da ovariectomia sobre os tecidos periodontais após o reimplante dentário imediato: análise histomorfométrica, imunoistoquímica e micro-ct em ratas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Biomechanical and Microstructural Benefits of Physical Exercise Associated With Risedronate in Bones of Ovariectomized Rats

Several treatments have been developed aiming the prevention of bone loss. There are discussions about the best prophylactic and therapeutic procedures for osteoporosis. This study evaluated the effects of physical exercise associated with risedronate as a prophylactic and therapeutic procedure in osteopenic bones of rats submitted to ovariectomy. We used 48 Wistar rats divided into: ovariectomized or subjected to sham surgery. Ovariectomized rats were divided into the following sub-groups: OVX, 12 weeks sedentary; OVX-EX, treadmill training for 12 weeks; OVX-RA, 12 weeks with risedronate administration; and OVX-EX-RA, 12 weeks with risedronate administration and treadmill training. Rats subjected to sham surgery were divided into the following sub-groups: SH, 12 weeks sedentary; SH-EX, treadmill training for 12 weeks; SH-RA, 12 weeks with risedronate administration; and SH-EX-RA, 12 weeks with risedronate administration and training on the treadmill. The effectiveness of the treatment was evaluated in tibias using biomechanical, radiological, histomorphometric, and immunohistochemical analyses. Data were analyzed by statistical tests, with significance level of P < 0.05. Results of mechanical tests showed that the SH-RA group had lower values compared with OVX-RA group; densitometry showed no significant differences; according to histomorphometric methods, OVX group presented lower results than the SH-EX, OVX-RA, SH-EX-RA, and OVX-EX-RA groups, and SH-EX-RA and OVX-EX-RA groups showed values higher than SH-RA, SH, and OVX-EX groups. The SH-EX-RA and OVX-EX-RA groups had decreased immunostaining for tartrate-resistant acid phosphatase and receptor activator of nuclear factor kappa-B ligand and increased osteoprotegerin immunostaining. In this experimental model, it was concluded that the physical training associated with use of risedronate exerted positive effects on biomechanical and microstructural properties in bones of ovariectomized rats. (C) 2014 Wiley Periodicals, Inc.

Efeitos do treinamento em natação sobre propriedades mecânicas e estruturais do fêmur de ratas ovariectomizadas

We investigated the effects of swimming training (ST) on femoral mechanical and structural properties in ovariectomized female rats. Female Wistar rats [age = 20 weeks; body weight (BW) = 271,42 +/- 17,6 g] were subjected to ovariectomy (OVX) or laparotomy (SHAM) and allocated to one of the following groups: swimming OVX (SO, n=12), control OVX (CO, n=12), swimming SHAM (SS, n=12) and control SHAM (CS, n=12). Fifteen days after surgery SO and SS groups were subjected to a ST (60 min/day, 5 days/week, overload of 3% of BW) for 10 weeks. Alkalin phosfatase was reduced in OVX as compared to SHAM (18,87 pg/mL vs. 53,93 pg/mL, respectively), but not altered by ST. Animals SHAM showed more cancellous bone than OVX (255,50 +/- 38,27 vs 288,75 +/- 39,63 points, respectively). Exercised animals exhibited more cancellous bone than controls (292,00 +/- 33,54 vs 251,54 +/- 38,99 points, respectively) in this region and in the grater trochanter (281,50 +/- 34,42 vs 237,23 +/- 53,03 points; respectively). Bone mineral density and cortical bone in the femur midshaft were not altered either by OVX or ST. The maximum force and thoughness of the femoral neck and midshaft were not affected either by OVX or ST. It was concluded that ST benefits cancellous bone mass in the femoral proximal region (i.e. femoral neck and greater trochanter), independently of ovariectomy, which did not reflect in improved mechanical properties either in the femoral neck or midshaft.

Healing of normal and osteopenic bone with titanium implant and low-level laser therapy (GaAlAs): a histomorphometric study in rats

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Ovarian blood vessel occlusion as a surgical sterilization method in rats

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Actions of oestradiol and progesterone on the prostate in female gerbils: reversal of the histological effects of castration

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Influência da sinvastatina na reparação óssea de mandíbulas da ratas ovariectomizadas e nos níveis de colesterol sanguíneo

Pós-graduação em Biopatologia Bucal - ICT

Candidose experimental e recuperação de candida albicans na cavidade bucal de ratas ovariectomizadas

Pós-graduação em Biopatologia Bucal - ICT

Treinamento em corrida de baixa intensidade: propriedades estruturais e mecânicas da epífise proximal do fêmur de ratas osteopênicas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Clinical, biomechanical and histological study on oophorectomy induced menopause

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Reparação óssea em alvéolos de ratas ovarectomizadas após implante com biovidro: análise histomorfométrica e imunoistoquímica

Pós-graduação em Odontologia - FOA

Efeito do tratamento com Raloxifeno sobre o processo de reparo de reimplante dentário tardio. Estudo histológico em ratas

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)