An optically coupled power stimulus isolation unit with high voltage and fast rise time output

Recent technological developments have created new devices that could improve and simplify the construction of stimulus isolators. HEXFET transistors can switch large currents and hundreds of volts in nanoseconds. The newer opto-isolators can give a pulse rise time of a few nanoseconds, with output compatible with MOSFET devices, in which delays are reduced to nanoseconds. Integrated DC/DC converters are now available. Using these new resources we developed a new electrical stimulus isolator circuit with selectable constant-current and constant-voltage modes, which are precise and easy to construct. The circuit works like a regulated power supply in both modes with output switched to zero or to free mode through an opto-isolator device. The isolator analyses showed good practical performance. The output to ground resistance was 1011 ohms and capacitance 35 picofarads. The rise time and fall time were identical (5 µs) and constant. The selectable voltage or current output mode made it very convenient to use. The current mode, with higher output resistance values in low current ranges, permits intracellular stimulation even with tip resistances close to 100 megaohms. The high compliance of 200 V guarantees the value of the current stimulus. The very low output resistance in the voltage mode made the device highly suitable for extracellular stimulation with low impedance electrodes. Most importantly, these characteristics were achieved with a circuit that was easy to build and modify and assembled with components available in Brazil.

The decreased oxygen uptake during progressive exercise in ischemia-induced heart failure is due to reduced cardiac output rate

We tested the hypothesis that the inability to increase cardiac output during exercise would explain the decreased rate of oxygen uptake (VO2) in recent onset, ischemia-induced heart failure rats. Nine normal control rats and 6 rats with ischemic heart failure were studied. Myocardial infarction was induced by coronary ligation. VO2 was measured during a ramp protocol test on a treadmill using a metabolic mask. Cardiac output was measured with a flow probe placed around the ascending aorta. Left ventricular end-diastolic pressure was higher in ischemic heart failure rats compared with normal control rats (17 ± 0.4 vs 8 ± 0.8 mmHg, P = 0.0001). Resting cardiac index (CI) tended to be lower in ischemic heart failure rats (P = 0.07). Resting heart rate (HR) and stroke volume index (SVI) did not differ significantly between ischemic heart failure rats and normal control rats. Peak VO2 was lower in ischemic heart failure rats (73.72 ± 7.37 vs 109.02 ± 27.87 mL min-1 kg-1, P = 0.005). The VO2 and CI responses during exercise were significantly lower in ischemic heart failure rats than in normal control rats. The temporal response of SVI, but not of HR, was significantly lower in ischemic heart failure rats than in normal control rats. Peak CI, HR, and SVI were lower in ischemic heart failure rats. The reduction in VO2 response during incremental exercise in an ischemic model of heart failure is due to the decreased cardiac output response, largely caused by depressed stroke volume kinetics.

Deviations of Governance In IT Multi-Sourcing: A Case Study

IT outsourcing (ITO) refers to the shift of IT/IS activities from internal to external of an organization. In prior research, the governance of ITO is recognized with persistent strategic importance for practice, because it is tightly related to ITO success. Under the rapid transformation of global market, the evolving practice of ITO requires updated knowledge on effective governance. However, research on ITO governance is still under developed due to the lack of integrated theoretical frameworks and the variety of empirical settings besides dyadic client-vendor relationships. Especially, as multi-sourcing has become an increasingly common practice in ITO, its new governance challenges must be attended by both ITO researchers and practitioners. To address this research gap, this study aims to understand multi-sourcing governance with an integrated theoretical framework incorporating both governance structure and governance mechanisms. The focus is on the emerging deviations among formal, perceived and practiced governance. With an interpretive perspective, a single case study is conducted with mixed methods of Social Network Analysis (SNA) and qualitative inquiries. The empirical setting embraces one client firm and its two IT suppliers for IT infrastructure services. The empirical material is analyzed at three levels: within one supplier firm, between the client and one supplier, and among all three firms. Empirical evidences, at all levels, illustrate various deviations in governance mechanisms, with which emerging governance structures are shaped. This dissertation contributes to the understanding of ITO governance in three domains: the governance of ITO in general, the governance of multi-sourcing in particular, and research methodology. For ITO governance in general, this study has identified two research strands of governance structure and governance mechanisms, and integrated both concepts under a unified framework. The composition of four research papers contributes to multi-sourcing research by illustrating the benefits of zooming in and out across the multilateral relationships with different aspects and scopes. Methodologically, the viability and benefit of mixed-method is illustrated and confirmed for both researchers and practitioners.

Reduced power output in skeletal muscles devoid of skMLCK: RLC phosphorylation contributes to peak performance

Regulatory light chain (RLC) phosphorylation in fast twitch muscle is catalyzed by skeletal myosin light chain kinase (skMLCK), a reaction known to increase muscle force, work, and power. The purpose of this study was to explore the contribution of RLC phosphorylation on the power of mouse fast muscle during high frequency (100 Hz) concentric contractions. To determine peak power shortening ramps (1.05 to 0.90 Lo) were applied to Wildtype (WT) and skMLCK knockout (skMLCK-/-) EDL muscles at a range of shortening velocities between 0.05-0.65 of maximal shortening velocity (Vmax), before and after a conditioning stimulus (CS). As a result, mean power was increased to 1.28 ± 0.05 and 1.11 ± .05 of pre-CS values, when collapsed for shortening velocity in WT and skMLCK-/-, respectively (n = 10). In addition, fitting each data set to a second order polynomial revealed that WT mice had significantly higher peak power output (27.67 ± 1.12 W/ kg-1) than skMLCK-/- (25.97 ± 1.02 W/ kg-1), (p < .05). No significant differences in optimal velocity for peak power were found between conditions and genotypes (p > .05). Analysis with Urea Glycerol PAGE determined that RLC phosphate content had been elevated in WT muscles from 8 to 63 % while minimal changes were observed in skMLCK-/- muscles: 3 and 8 %, respectively. Therefore, the lack of stimulation induced increase in RLC phosphate content resulted in a ~40 % smaller enhancement of mean power in skMLCK-/-. The increase in power output in WT mice suggests that RLC phosphorylation is a major potentiating component required for achieving peak muscle performance during brief high frequency concentric contractions.

Land Ownership, Working Capital, and the Agricultural Output: Egypt, 1913-1958.

A simple model is constructed in which short-term credit is needed to finance the purchase of inputs, in which there is bankruptcy risk, and in which we argue were important characteristics of Egyptian agriculture during the first half of this century, result in aggregate agricultural output being dependant on the distribution of land ownership. The main theorical insight is that aggregate agricultural output will be increased by a decrease in the inequality of the distribution of land ownership when returns to scale are decreasing. Testable short- and long-run empirical propositions are formulated and carefully tested on Egyptian data for the 1913-1958 period. We find that, controlling for factor inputs, there is no tradeoff between equity and efficiency for Egyptian agriculture - they go hand in hand in the short run.

Land Ownership, Working Capital, and the Agricultural Output: Egypt, 1913-1958.

A simple model is constructed in which short-term credit is needed to finance the purchase of inputs, in which there is bankruptcy risk, and in which we argue were important characteristics of Egyptian agriculture during the first half of this century, result in aggregate agricultural output being dependant on the distribution of land ownership. The main theorical insight is that aggregate agricultural output will be increased by a decrease in the inequality of the distribution of land ownership when returns to scale are decreasing. Testable short- and long-run empirical propositions are formulated and carefully tested on Egyptian data for the 1913-1958 period. We find that, controlling for factor inputs, there is no tradeoff between equity and efficiency for Egyptian agriculture - they go hand in hand in the short run.

Movement of Input and Output Prices of Rice in Kerala and its Impact on Area, Yield and Outp

Rice is the most extensively cultivated crop in the world, particularly concentrated in Asia and the Far East. Asian countries together make up for as much as 91.80 per cent of the world production of rice in 1986. The main objective of the present study is to analyse the rice economy of Kerala over time and space at the State, district and taluk level. The thesis analyses the trends in area, yield and total production of rice during the three seasons in the state, districts and taluks and studies the trends in input and output prices of rice and coconut in the state, districts and taluks. The researcher estimates the impact of input and output prices on area, yield and total output of rice in the state, districts and selected taluks and examines the conversion of paddy field into coconut garden and rubber plantation.

Entwicklung eines Windleistungprognosemodells zur Verbesserung der Kraftwerkseinsatzplanung

Die Maßnahmen zur Förderung der Windenergie in Deutschland haben wichtige Anstöße zur technologischen Weiterentwicklung geliefert und die Grundlagen für den enormen Anlagenzubau geschaffen. Die installierte Windleistung hat heute eine beachtliche Größenordnung erreicht und ein weiteres Wachstum in ähnlichen Dimensionen ist auch für die nächsten Jahre zu erwarten. Die aus Wind erzeugte elektrische Leistung deckt bereits heute in einigen Netzbereichen die Netzlast zu Schwachlastzeiten. Dies zeigt, dass die Windenergie ein nicht mehr zu vernachlässigender Faktor in der elektrischen Energieversorgung geworden ist. Im Rahmen der Kraftwerkseinsatzplanung sind Betrag und Verlauf der Windleistung des folgenden Tages mittlerweile zu wichtigen und zugleich schwierig zu bestimmenden Variablen geworden. Starke Schwankungen und falsche Prognosen der Windstromeinspeisung verursachen zusätzlichen Bedarf an Regel- und Ausgleichsleistung durch die Systemführung. Das im Rahmen dieser Arbeit entwickelte Prognosemodell liefert die zu erwartenden Windleistungen an 16 repräsentativen Windparks bzw. Gruppen von Windparks für bis zu 48 Stunden im Voraus. Aufgrund von prognostizierten Wetterdaten des deutschen Wetterdienstes (DWD) werden die Leistungen der einzelnen Windparks mit Hilfe von künstlichen neuronalen Netzen (KNN) berechnet. Diese Methode hat gegenüber physikalischen Verfahren den Vorteil, dass der komplexe Zusammenhang zwischen Wettergeschehen und Windparkleistung nicht aufwendig analysiert und detailliert mathematisch beschrieben werden muss, sondern anhand von Daten aus der Vergangenheit von den KNN gelernt wird. Das Prognosemodell besteht aus zwei Modulen. Mit dem ersten wird, basierend auf den meteorologischen Vorhersagen des DWD, eine Prognose für den Folgetag erstellt. Das zweite Modul bezieht die online gemessenen Leistungsdaten der repräsentativen Windparks mit ein, um die ursprüngliche Folgetagsprognose zu verbessern und eine sehr genaue Kurzzeitprognose für die nächsten drei bis sechs Stunden zu berechnen. Mit den Ergebnissen der Prognosemodule für die repräsentativen Standorte wird dann über ein Transformationsmodell, dem so genannten Online-Modell, die Gesamteinspeisung in einem größeren Gebiet berechnet. Das Prognoseverfahren hat seine besonderen Vorzüge in der Genauigkeit, den geringen Rechenzeiten und den niedrigen Betriebskosten, da durch die Verwendung des bereits implementierten Online-Modells nur eine geringe Anzahl von Vorhersage- und Messstandorten benötigt wird. Das hier vorgestellte Prognosemodell wurde ursprünglich für die E.ON-Netz GmbH entwickelt und optimiert und ist dort seit Juli 2001 im Einsatz. Es lässt sich jedoch auch leicht an andere Gebiete anpassen. Benötigt werden dazu nur die Messdaten der Leistung ausgewählter repräsentativer Windparks sowie die dazu gehörenden Wettervorhersagen, um die KNN entsprechend zu trainieren.

Vom Input zum Output

Infolge der durch die internationalen Schulvergleichstests eingeleiteten empirischen Wende in der Erziehungswissenschaft hat sich die Aufmerksamkeit vom Input schulischen Lehrens und Lernens zunehmend auf die Ergebnisse (Output) bzw. Wirkungen (Outcomes) verlagert. Die Kernfrage lautet nun: Was kommt am Ende in der Schule bzw. im Unterricht eigentlich heraus? Grundlegende Voraussetzung ergebnisorienterter Steuerung schulischen Unterrichts ist die Formulierung von Bildungsstandards. Wie Bildungsstandards mit Kompetenzmodellen und konkreten Aufgabenstellungen im Unterricht des Faches "Politik & Wirtschaft" verknüpft werden können, wird in diesem Beitrag einer genaueren Analyse unterzogen. Vor dem Hintergrund bildungstheoretischer Vorstellungen im Anschluss an Immanuel Kant kommen dabei das Literacy-Konzept der Pisa-Studie sowie die "Dokumentarische Methode" nach Karl Mannheim zur Anwendung.

Output from the 1998 Product Development Value Stream Workshop: A Framework for Understanding Information Flow in the Product Development Process

The descriptions below and the attached diagrams are outputs of the 1998 LAI Product Development Focus Team workshop on the Value Chain in Product Development. A working group at that workshop was asked to model the product development process: in terms of the phases of product development and their interfaces, boundaries and outputs. Their work has proven to be generally useful to LAI researchers and industry members, and so is formalized here.

Sistema de información geográfica para web con informaciones espaciales (geográficas) de output y input para expediciones

This project is a Web Geographic Information System built on an Open Source geographic structure like MapServer (Minnesota University) and PostgreSQL/PostGIS (object relational database management system). The study case is a web site for expeditions in a specific Brazilian region

Digital Output

Slides from Lecture on making PDF's - the de facto standard for printing and setting up your own publishing and distribution channel via a Blog!