110-W fiber laser with homemade double-clad fiber

A high-power ytterbium-doped fiber laser (YDFL) with homemade double-clad fiber (DCF) is introduced in this letter. The geometric parameter and laser characteristics of the fiber have been studied. With one-end-pumping scheme, pumped by a high-power laser diode with launching power of 280 W, a maximum continuous wave (CW) output of 110 W is obtained with an optical-to-optical efficiency of 40%.

Projeto de redes neurais para determinar os ganhos PID de um sistema de posicionamento din��mico de uma embarca����o.

As sintonias dos Controladores PID existentes em um Sistema de Posicionamento Din��mico, utilizado em embarca����es e plataformas a fim de manter uma posi����o fixa em alto-mar ou de realizar determinada manobra, sempre tem sido um desafio a ser vencido. Trata-se de uma tarefa demorada, dependente das condi����es ambientais e com um elevado custo financeiro, uma vez que as horas dedicadas do profissional habilitado s��o caras. Al��m disso, a embarca����o deve-se manter estabilizada durante o per��odo de tempo no qual determinada fun����o �� realizada, como por exemplo, perfura����o, abastecimento, ou lan��amento de dutos. Foi utilizado um software para simular o posicionamento de uma embarca����o em alto-mar sob diversas condi����es de vento e correnteza, com o qual foi poss��vel verificar a influ��ncia da sintonia dos par��metros PID do Controlador no desempenho do sistema de controle. O Sistema din��mico abordado possui um comportamento n��o linear e sujeito a fortes dist��rbios n��o medidos, o que s��o apenas alguns exemplos de quest��es avaliadas deste trabalho. Neste contexto, foram projetadas Redes Neurais com o intuito de aprimorar a t��cnica utilizada para determinar os ganhos de um dos Controladores PID de um Sistema de Posicionamento Din��mico. Os melhores resultados foram obtidos atrav��s da avalia����o de desempenho de diversas simula����es de Redes Neurais que revelam a viabilidade da implementa����o da sintonia autom��tica de Controladores em Sistemas de Posicionamento Din��mico.

Sa��de p��blica, inova����o farmac��utica e propriedade intelectual: o desenvolvimento de um novo medicamento contra a mal��ria no Brasil

Esta disserta����o tem como objetivo estudar a rela����o entre propriedade intelectual, inova����o e sa��de p��blica, com foco na an��lise do cons��rcio farmac��utico para desenvolvimento do medicamento combina����o em dose fixa artesunato-mefloquina (ASMQ) contra a mal��ria. A concep����o dessa iniciativa se insere num momento hist��rico, final dos anos 1990 e in��cio dos anos 2000, em que estudos apontaram a insufici��ncia da pesquisa e desenvolvimento para as doen��as negligenciadas. Na ��poca, o cen��rio da mal��ria era particularmente preocupante, dada a dissemina����o de resist��ncia aos medicamentos dispon��veis e �� falta de perspectiva do lan��amento de novos produtos contra a doen��a. Para proteger a ��ltima classe de antimal��ricos eficazes, a saber,os derivados a base de artemisinina, uma estrat��gia encontrada foi a do recurso �� terapia combinada a base de artemisinina (artemisinin based combination therapy ACT). Contudo, dos 4 ACTs recomendados pela OMS em 2001, apenas 1 se encontrava dispon��vel no mercado. O projeto FACT foi ent��o criado, em 2002, com o prop��sito de desenvolver dois novos ACTs artesunato-mefloquina e artesunato-amodiaquina. O cons��rcio do ASMQ, por suas especificidades, em particular a produ����o de inova����o por um laborat��rio p��blico do Sul e a circula����o Sul-Sul de conhecimentos e tecnologias , o tornam de interesse para estudos nos campos da bio��tica e da sa��de p��blica; tendo sido, por isso, escolhido como objeto desta disserta����o. O estudo se apoiou em pesquisa bibliogr��fica, de fundamental relev��ncia para a compreens��o dos problemas de acesso e de disponibilidade de novos produtos para doen��as negligenciadas, decorrentes de um modelo de inova����o farmac��utica sustentado em patentes. De forma complementar, foram feitos: i) trabalho de observa����o durante a 65a Assembleia Mundial da Sa��de, da Organiza����o Mundial da Sa��dem, evento de import��ncia para os debates sobre propriedade intelectual e interesse p��blico; e ii) entrevistas com integrantes de equipes das duas principais institui����es participantes do cons��rcio FACT (Farmanguinhos/Fiocruz e DNDi).

Annual Report of the Game and Fisheries Department for the period 1st July 1956 to 30th June, 1957

This report continues to cover the period of the financial year. Although, as before, for the sake of continuity and accuracy many of the statistics refer to the calendar year. The year has been notable in particular for the launching of extensive research projects on wild-life conservation problems, and much progress has already been made. This has been rendered possible by the greatly appreciated help and interest of the Fulbright Commission, who arranged for three experienced American wild-life scientists to work on these problems in Uganda. The latter have been working in conjunction with The Game and Fisheries Department's Biologist, as a team under the general Direction of the recently created Fauna Research Committee.

Mode division multiplexing exploring hollow-core photonic bandgap fibers

We review our recent exploratory investigations on mode division multiplexing using hollow-core photonic bandgap fibers (HC-PBGFs). Compared with traditional multimode fibers, HC-PBGFs have several attractive features such as ultra-low nonlinearities, low-loss transmission window around 2 ��m etc. After having discussed the potential and challenges of using HC-PBGFs as transmission fibers for mode multiplexing applications, we will report a number of recent proof-of-concept results obtained in our group using direct detection receivers. The first one is the transmission of two 10.7 Gbit/s non-return to zero (NRZ) data signals over a 30 m 7-cell HC-PBGF using the offset mode launching method. In another experiment, a short piece of 19-cell HC-PBGF was used to transmit two 20 Gbit/s NRZ channels using a spatial light modulator for precise mode excitation. Bit-error-ratio (BER) performances below the forward-error-correction (FEC) threshold limit (3.3��10-3) are confirmed for both data channels when they propagate simultaneously. �� 2013 IEEE.

Quantum key distribution for 10 Gb/s dense wavelength division multiplexing networks

We demonstrate quantum key distribution (QKD) with bidirectional 10 Gb/s classical data channels in a single fiber using dense wavelength division multiplexing. Record secure key rates of 2.38 Mbps and fiber distances up to 70km are achieved. Data channels are simultaneously monitored for error-free operation. The robustness of QKD is further demonstrated with a secure key rate of 445 kbps over 25km, obtained in the presence of data lasers launching conventional 0 dBm power. We discuss the fundamental limit for the QKD performance in the multiplexing environment. �� 2014 AIP Publishing LLC.

���������������������������������������������������

���������������������������������������������������������������������������������������������,������������������������������������������������������������������������������������������������������������������,���������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������,���������������������������������������������������������,���������������������������������������������������������������������������������������������������������������������������������������

Il Sistema di Revenue Management strumento per lo sviluppo turistico sostenibile delle destinazioni

Businesses interact constantly with the environment, realizing several and heterogeneous exchanges. Organizations can be considered a system of different interests, frequently conflicting and the satisfaction of different stakeholders is a condition of success and survival. National and international literature attempts to explain the complex connection between companies and environment. In particular, the Stakeholder Theory considers crucial for businesses the identification of different stakeholders and their involvement in decision-making process. In this context, profit can not be considered the only purpose of companies existence and business aims become more numerous and different. The Stakeholder Theory is often utilized as framework for tourism studies, in particular in Sustainable Tourism Development research. In fact, authors consider sustainable the tourism development able to satisfy interests of different stakeholders, traditionally identified as local community and government, businesses, tourists and natural environment. Tourism businesses have to guarantee the optimal use of natural resources, the respect of socio-cultural tradition of local community and the creation of socio-economic benefits for all stakeholders in destinations. An obstacle to sustainable tourism development that characterizes a number of destinations worldwide is tourism demand seasonality. In fact, its negative impact on the environment, economy and communities may be highly significant. Pollution, difficulties in the use of public services, stress for residents, seasonal incomes, are all examples of the negative effects of seasonality. According to the World Tourism Organization (2004) the limitation of seasonality can favour the sustainability of tourism. Literature suggests private and public strategies to minimize the negative effects of tourism seasonality, as diversification of tourism products, identification of new market segments, launching events, application of public instruments like eco-taxes and use of differential pricing policies. Revenue Management is a managerial system based on differential pricing and able to affect price sensitive tourists. This research attempts to verify if Revenue Management, created to maximize profits in tourism companies, can also mitigate the seasonality of tourism demand, producing benefits for different stakeholders of destinations and contributing to Sustainable Tourism Development. In particular, the study attempts to answer the following research questions: 1) Can Revenue Management control the flow of tourist demand? 2) Can Revenue Management limit seasonality, producing benefits for different stakeholders of a destination? 3) Can Revenue Management favor the development of Sustainable Tourism? The literature review on Stakeholder Theory, Sustainable Tourism Development, tourism seasonality and Revenue Management forms the foundation of the research, based on a case study approach looking at a significant destination located in the Southern coast of Sardinia, Italy. A deductive methodology was applied and qualitative and quantitative methods were utilized. This study shows that Revenue Management has the potential to limit tourism seasonality, to mitigate negative impacts occurring from tourism activities, producing benefits for local community and to contribute to Sustainable Tourism Development.

Characterization of basal pseudopod-like processes in ileal and colonic PYY cells.

The peptide tyrosine tyrosine (PYY) is produced and secreted from L cells of the gastrointestinal mucosa. To study the anatomy and function of PYY-secreting L cells, we developed a transgenic PYY-green fluorescent protein mouse model. PYY-containing cells exhibited green fluorescence under UV light and were immunoreactive to antibodies against PYY and GLP-1 (glucagon-like peptide-1, an incretin hormone also secreted by L cells). PYY-GFP cells from 15 ��m thick sections were imaged using confocal laser scanning microscopy and three-dimensionally (3D) reconstructed. Results revealed unique details of the anatomical differences between ileal and colonic PYY-GFP cells. In ileal villi, the apical portion of PYY cells makes minimal contact with the lumen of the gut. Long pseudopod-like basal processes extend from these cells and form an interface between the mucosal epithelium and the lamina propria. Some basal processes are up to 50 ��m in length. Multiple processes can be seen protruding from one cell and these often have a terminus resembling a synapse that appears to interact with neighboring cells. In colonic crypts, PYY-GFP cells adopt a spindle-like shape and weave in between epithelial cells, while maintaining contact with the lumen and lamina propria. In both tissues, cytoplasmic granules containing the hormones PYY and GLP-1 are confined to the base of the cell, often filling the basal process. The anatomical arrangement of these structures suggests a dual function as a dock for receptors to survey absorbed nutrients and as a launching platform for hormone secretion in a paracrine fashion.

Measurements and simulations of noise imposed on supercontinuum generated in microstructure fiber

We present experimental and theoretical investigations of the highly nonlinear and broadband noise that exists on supercontinuum spectra generated from launching femtosecond Ti:Sapphire pulses into microstructure fiber.

Surface plasmon polariton propagation length: A direct comparison using photon scanning tunneling microscopy and attenuated total reflection

The propagation of surface plasmon polaritons (SPP's) is studied using a photon scanning tunneling microscope (PSTM) and conventional attenuated total reflection (ATR). The PSTM experiment uses localized (focused beam) launching or SPP's at a wavelength of 632.8 nm. Propagation of the SPP is observed as an exponentially decaying tail beyond the launch site acid the 1/e propagation length is measured directly for a series of Ag films of different thicknesses. The ATR measurements are used to characterize the thin film optical and thickness parameters, revealing, notably, the presence of a contaminating adlayer of Ag2S of typical dielectric function, 8.7 + i2.7, and thickness 1-2 nm. Values of the SPP propagation length, based on the ATR- derived film parameters used in the four-media implicit SPP dispersion relation, show very good agreement with those based on the PSTM images for the case of undercoupled or optimally coupled SPP modes. The observed propagation lengths are quantitatively analyzed taking explicit account of additional intrinsic damping due to the growth of the Ag2S layer and of reradiation of the SPP back into the prism outside the launch site. Finally, the PSTM images show excellent SPP beam confinement in the original propagation direction.

Discovery of multiple neuropeptide families in the phylum Platyhelminthes

Available evidence shows that short amidated neuropeptides are widespread and have important functions within the nervous systems of all flatworms (phylum Platyhelminthes) examined, and could therefore represent a starting point for new lead drug compounds with which to combat parasitic helminth infections. However, only a handful of these peptides have been characterised, the rigorous exploration of the flatworm peptide signalling repertoire having been hindered by the dearth of flatworm genomic data. Through searches of both expressed sequence tags and genomic resources using the basic local alignment search tool (BLAST), we describe 96 neuropeptides on 60 precursors from 10 flatworm species. Most of these (51 predicted peptides on 14 precursors) are novel and are apparently restricted to flatworms; the remainder comprise nine recognised peptide families including FMRFamide-like (FLPs), neuropeptide F (NPF)-like, myomodulin-like, buccalin-like and neuropeptide FF (NPFF)-like peptides; notably, the latter have only previously been reported in vertebrates. Selected peptides were localised immunocytochemically to the Schistosoma mansoni nervous system. We also describe several novel flatworm NPFs with structural features characteristic of the vertebrate neuropeptide Y (NPY) superfamily, previously unreported characteristics which support the common ancestry of flatworm NPFs with the NPY-superfamily. Our dataset provides a springboard for investigation of the functional biology and therapeutic potential of neuropeptides in flatworms, simultaneously launching flatworm neurobiology into the post-genomic era. (C) 2009 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

Convict Criminology: Provocazioni da Oltreoceano. La Ricerca Etnografica in Carcere

This review essay describes the New School of Convict Criminology through an analysis of its main manifesto and some of the more recent articles which have been published on the subject. It suggests that this new brand of criminology is placed on a continuum with the established tradition of critical criminology without arriving at its most radical consequences: abolitionism. The school���s endeavor is that of launching a ���realist criminology��� able to change prisoners��� conditions and facilitating their re-entry in society, starting from consideration of their personal needs rather than from legislative issues. The School which was led by John Irwin is constituted by former prisoners and embrace ethnographic research as the only way to understand inmates��� conditions.

Dubai revisited: is new planned housing sustainable?

Dubai, the second largest city of the United Arab Emirates, is a fast growing hub with increasing need for infrastructure, housing and public facilities. Dubai is trying to market itself as an attractive holiday destination, which saw the launching and building of large scale planned communities, some of which are located on reclaimed land along the city's coast line. This paper reviews Dubai\'s green building agenda by examining the scale and typologies of new and planned low carbon projects, and discusses the potential of renewable sources of energy that can reduce the country's dependence on fossil fuels and improve the country's long term sustainability. It assesses the potential of solar energy, wind power, and geo-thermal energy in Dubai and the UAE in general.

Magneto-optical trapping and background-free imaging for atoms near nanostructured surfaces

We demonstrate a combined magneto-optical trap and imaging system that is suitable for the investigation of cold atoms near surfaces. In particular, we are able to trap atoms close to optically scattering surfaces and to image them with an excellent signal-to-noise ratio. We also demonstrate a simple magneto-optical atom cloud launching method. We anticipate that this system will be useful for a range of experimental studies of novel atom-surface interactions and atom trap miniaturization.