A Novel Chemically Modified Curcumin Reduces Severity of Experimental Periodontal Disease in Rats: Initial Observations

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Severe secondary hyperparathyroidism and panoramic radiography parameters

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Total Spontaneous Regression of a Central Giant Cell Granuloma After Incisional Biopsy: A Four-Year Follow-Up Case Report

Central giant cell granuloma (CGCG) of the jaws represents a localized and benign neoplastic lesion sometimes characterized by aggressive osteolytic proliferation. The World Health Organization defines it as an intraosseous lesion composed of cellular and dense connective tissues that contain multiple hemorrhagic foci, an aggregation of multinucleated giant cells, and occasional bone tissue trabeculae. The origin of this lesion is uncertain; however, factors such as local trauma, inflammation, intraosseous hemorrhage, and genetic abnormalities have been identified as possible causes. CGCG generally affects those younger than 30 years and occurs more frequently in women (2: 1). This lesion corresponds to approximately 7% of all benign tumors of the jaws, with prevalence in the anterior region of the jaw. Aggressive lesions are characterized by symptoms, such as pain, numbness, rapid growth, cortical perforation, root resorption, and a high recurrence rate after curettage. In contrast, nonaggressive CGCGs have a slow rate of growth, may contain sparse trabeculation, and are less likely to move teeth or cause root resorption or cortical perforation. Nonaggressive CGCGs are generally asymptomatic lesions and thus are frequently found on routine dental radiographs. Radiographically, the 2 forms of CGCG present as radiolucent, expansive, unilocular or multilocular masses with well-defined margins. The histopathology of CGCG is characterized by multinucleated giant cells, surrounded by round, oval, and spindle-shaped mononuclear cells, scattered in dense connective tissue with hemorrhagic and abundant vascularization foci. The final diagnosis is determined by histopathologic analysis of the biopsy specimen. The preferred treatment for CGCG consists of excisional biopsy, curettage with a safety margin, and partial or total resection of the affected bone. Conservative treatments include local injections of steroids, calcitonin, and antiangiogenic therapy. Drug treatment using antibiotics, painkillers, and corticosteroids and clinical and radiographic monitoring are necessary for approximately 10 days after surgery. There are only a few cases of spontaneous CGCG regression described in the literature; therefore, a detailed case report of CGCG regression in a 12-yearold boy with a 4-year follow-up is presented and compared with previous studies. (c) 2014 American Association of Oral and Maxillofacial Surgeons

Efeito do raloxifeno na lesão periapical em ratas ovariectomizadas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Central Giant Cell Granuloma in Pediatric Maxilla: Surgical Management

Central giant cell granuloma (CGCG) is an intraosseous lesion consisting of fibrous cellular tissue that contains multiple foci of hemorrhage, multinucleated giant cells, and occasional trabeculae of woven bone. An 8-year-old boy presented himself complaining of a painless swelling in the left maxilla that had started 1 year. Computed tomography (CT) scan confirmed a poorly defined multilocular radiolucent lesion in the left maxilla crossing the midline. The patient underwent enucleation through an intraoral approach of the lesion. The biopsy revealed multinucleated giant cells in a fibrous stroma. A CT was taken approximately 1 year postoperatively. There was no clinical or radiographic evidence of recurrence. Therefore, surgical treatment of CGCG can be performed, trying to preserve the surrounding anatomic structures, which can be maintained in case the lesion does not show an aggressive clinical behavior, avoiding large surgical defects which are undesirable in children.

Metabolismo oxidativo sérico em ratos diabéticos com lesão periapical

Pós-graduação em Ciência Odontólogica - FOA

Estabilidade esquelética da multisegmentação maxilar

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Expressão de genes relacionados à remodelação óssea na fase inicial da reabsorção do rebordo residual em mandíbulas humanas

Pós-graduação em Biopatologia Bucal - ICT

Caracterização radiográfica ex vivo de biomateriais utilizados para regeneração óssea em mandíbulas de porcos

Introduction: The radiographic characteristics of a biomaterial, such as its density, may influence the evaluation of the results obtained following its clinical use. Objective: The aim of this study was to evaluate the radiographic density of biomaterials used as bone substitutes, inserted into dental sockets and bone defects in created in the jaws of pigs. The influence of a soft tissue simulator on the results was also evaluated. Material and method: Two and three-millimeter-deep bone defects were created in the pigs mandible and the right first molar extraction socket were used. Commercial samples of five biomaterials were tested: Hydroxyapatite, Lyophilized Bovine Bone, 45S5 bioglass (generic), PerioGlass and β-Tri-Calcium Phosphate, and compared to a positive (mandibular bone) and negative (empty alveolar bone defects) controls. Radiographic images were acquired with and without a 10 mm thick soft-tissue simulator. Result: The results for the extraction sockets showed no differences between the biomaterials and the negative control. For the bone defects, the depth of the defect density influenced the density, both in the negative control (p < 0.01) and biomaterials (p < 0.05) groups. The soft- tissue simulator did not alter the results. Conclusion: The type of the evaluated defect can interfere in the radiographic features presented by each biomaterial, while the simulation of soft tissues was not statistically significant.

Implantes curtos em região posterior da mandíbula

The rehabilitation of edentulous areas with osseointegrated dental implants is a well-documented, predictable procedure in the literature, with high success rates. However, the lack of bone at the recipient bed or proximity to anatomic structures limits the rehabilitation procedure especially at the posterior mandible. Thus, short implants are an alternative treatment for such cases of severe bone resorption. The purpose of this study was to review the success rate of short implants, especially those based in the posterior mandible and to show a clinical case. A literature review was made on electronic databases PubMed and Bireme with articles published between the years 2005 to 2012, using the keywords "short dental implants". It was concluded that the success rates of short implants are similar to those presented by conventional implants but still related to their geometry and surface treatment. Also, short implants can be considered as a viable alternative for the rehabilitation of severely resorbed jaws. However, many authors consider that more research is necessary when a short implant is compared to a long dental implant.

Protocolo mandibular com implantes curtos

Jaws atrophy represents a great challenge to Implantology regarding rehabilitation of edentulous areas. This paper reports an extreme mandibular atrophy with only 9mm of height between the mental foramina. In these situations, treatment options include bone augmentation techniques, transmandibular, or short dental implants. It is well accepted that bone grafts to improve height do not have good predictability. Besides, osteogenic distraction is associated with a great patient discomfort and transmandibular implants are related with high failure rates. Also, surgical-prosthetic rehabilitations with short dental implants had been associated to good success rates. The purpose of this clinical case is to report a severe mandibular atrophy, successfully treated with four short dental implants between mental foramina for implant-supported prosthesis.

Prótese metalocerâmica associada à prótese metaloplástica implantossuportada em paciente desdentado total

The use of different methods and materials should be considered during the planning of implant-supported prostheses. Complications such as fractures of the acrylic resin base, wear and fracture of teeth can occur frequently, creating the need for careful planning for each patient, which can make the selection of the type of treatment more complex. Thus, this article describes the oral rehabilitation of a completely edentulous patient with bimaxillary fixed implant-supported prosthesis, with complaints on aesthetics, loss of vertical dimension and fracture of acrylic resin teeth of the upper arch. After the restoration of vertical dimension, his dentures were replaced with new bimaxillary implant-supported fixed prostheses, ceramic and acrylic resin were used as veneering material for maxilla and mandible, respectively. At the end of the treatment, the patient received bimaxillary flat occlusal splints to protect the teeth and implants of possible parafunctional habits. The approach for the treatment allowed a quick and effective resolution, with aesthetic and functional outcomes very favorable for the patient.

Implantes curtos revisão da literatura

The contemporary implant dentistry is in constant technological development, improving the oral rehabilitation process of partial or totally edentulous patients. On the other hand, anatomical limitations, such as the maxillary sinus and the mandibular canal in the posterior region of the jaws can limit the implant placement. Furthermore, due to the absence of dental elements, alveolar ridge atrophy is frequently observed. This aspect represents a loss either in quantity or quality of the bone tissue available for the dental implant rehabilitation. To make possible the dental implant rehabilitation even in adverse conditions, some solutions have been considered, such as the use of short implants (≤ 10 mm length) and/or small diameter implants (2,8; 3,3 and 3,5 mm width). The aim of this study is to present a literature review considering the use of short implants in oral rehabilitation, presenting the currently view of the matter. Based on the literature review, the use of short implants produced similar clinical success to conventional implants (greater than 10 mm in length). Therefore, its use can be considered a viable alternative, where anatomical limitations are present.

Avaliação da espessura da mandíbula com relação à fixação interna rígida em osteotomia sagital: estudo anatômico

Purpose: Trying to provide more anatomical data to the oral and maxillofacial surgeons regarding to orthognathic surgery, specifically about sagittal split osteotomy, the authors accomplished an anatomical study in dry human jaws, measuring the thickness in four previously established points of the body and mandibular ramus, at the usual spots used for the internal fixation by screws. Material and Methods: The authors also use the data collected to evaluate if there are significant differences between the group I (human dry mandibles with teeth) and group II (edentulous human dry mandibles). Results: For the group I the authors found the following results: x1 = 14,48, x2 = 14,94, x3=12,82 and x4 = 9,41, being the x2 the thickest point, and the least thick the x4. However in the group II, the found medium values were: x1 = 13,38, x2 = 13,08, x3 = 11,63 and x4 = 12,18, being the thickest point in that group the x1 and the least thick x3. The coefficient of simple correlation between the variables (group I and II) revealed a value of 0,6194, being this difference no significant at the meaning level of 95%.

Estudo anatomico da posição do forame mandibular e da língula em mandíbulas secas

Purpose: The authors tried to verify the anatomic location of the mandibular foramen and língula in dry jaws regarding the anterior and posterior border of the mandible and the incisure, alveolar border and mandibular base, in order to correlate the data with the sagittal split ramus osteotomy. Methods: There were evaluated 44 mandibles (88 sides) from the Morphology Department of the Araraquara Dental School of the São Paulo University (UNESP). The distances measured were previously deter - mined according to the figures presented in this article and were done by the use of a sliding caliper (Brow & Sharpe Digit-Cal Plus), with the mandibles positioned over a Erickson table, and the distan - ces were always measured in millimeters. Results: The pre-determined points and distances founded were X=17,67; Y=14,35; W=20,96 and Z=21,89 for the mandibular foramen, and the relationship between this anatomical structure and the língula shows that the mandibular foramen is in average 5,82 mm below the língula. Conclusions: The authors conclude that the mandibular foramen is lightly posterior in comparison with the ramus mandibular center and that the língula is a very important anatomic landmark for the ramus surgeries as well the knowledge of the distance between it and the mandibular foramen entrance.