Microbiology of the human intestinal tract and approaches for its dietary modulation

Gut bacteria can be categorised as being either beneficial or potentially pathogenic due to their metabolic activities and fermentation end-products. Health-promoting effects of the microflora may include immunostimulation, improved digestion and absorption, vitamin synthesis, inhibition of the growth of potential pathogens and lowering of gas distension. Detrimental effects are carcinogen production, intestinal putrefaction, toxin production, diarrhoea/constipation and intestinal infections. Certain indigenous bacteria such as bifidobacteria and lactobacilli are considered to be examples of health-promoting constituents of the microflora. They may aid digestion of lactose in lactose-intolerant individuals, reduce diarrhoea, help resist infections and assist in inflammatory conditions. Probiotics, prebiotics and synbiotics are functional foods that fortify the lactate producing microflora of the human or animal gut.

The role of the gastrointestinal microbiota in colorectal cancer

Both environmental and genetic factors contribute to cancers of the gastrointestinal tract including, the stomach, colon and rectum. The mechanisms associated with gastrointestinal cancer causation and prevention are largely unknown and the subject of much research. Many of the proposed mechanisms implicate the metabolic activities of the bacterial biota normally resident in the gastrointestinal tract. This review examines both the adverse and beneficial consequences of bacterial activity of the gastrointestinal tract focusing, in particularly on the stomach and large intestine. Studies on the role of the bacterial biota in colon carcinogenesis have also resulted in several useful biomarkers for use in human.

A new scenario framework for climate change research: background, process, and future directions

The scientific community is developing new global, regional, and sectoral scenarios to facilitate interdisciplinary research and assessment to explore the range of possible future climates and related physical changes that could pose risks to human and natural systems; how these changes could interact with social, economic, and environmental development pathways; the degree to which mitigation and adaptation policies can avoid and reduce risks; the costs and benefits of various policy mixes; residual impacts under alternative pathways; and the relationship of future climate change and adaptation and mitigation policy responses with sustainable development. This paper provides the background to and process of developing the conceptual framework for these scenarios, as described in the three subsequent papers in this Special Issue (Van Vuuren et al.; O’Neill et al.; Kriegler et al.). The paper also discusses research needs to further develop and apply this framework. A key goal of the current framework design and its future development is to facilitate the collaboration of climate change researchers from a broad range of perspectives and disciplines to develop policy- and decision-relevant scenarios and explore the challenges and opportunities human and natural systems could face with additional climate change.

Glycemic Index, glycemic control and beyond

It is currently estimated that over 370 million individuals have diabetes, making diabetes a major public health issue contributing significantly to global morbidity and mortality. The steep rise in diabetes prevalence over the past decades is attributable, in a large part, to lifestyle changes, with dietary habits and behaviour significant contributors. Despite the relatively wide availability of anti-diabetic medicine, it is lifestyle approaches that still remain the cornerstone of diabetes prevention and treatment. Glycemic index (GI) is a nutritional tool, which represents the glycemic response to carbohydrate ingestion. In light of the major impact of nutrition on diabetes pathophysiology, with the rising need to combat the escalating diabetes epidemic, this review will focus on the role of GI in glycemic control, the primary target of diabetic treatment and beyond. The review will present the evidence relating GI and diabetes treatment and prevention, as well as weight loss, weight maintenance and CVD risk factors.

Modelagem organizacional da Comissão Nacional de Energia Nuclear (Cnen): da crítica à esperança

This research had the objective to verify if the current organization design of the Comissão Nacional de Energia Nuclear (CNEN) facilitates or makes it difficult the reach of the organization performance. In order to make the analysis, the used ways had been bibliographic, documental and field researches. The bibliographical survey allowed to conclude that it has a necessity of searching a balance between the objectivist and subjectivist approaches of the theory of the organization design. The documental survey supplied elements that they make possible to understand the main phases of the development of the CNEN in elapsing of the time and that they explain the current organization design. Finally, the research of field, carried through with the main managers of the institution, made possible the data-collecting that contributed to ratify the initial assumption of the research of that the current organization design of the CNEN makes it difficult the performance of the organization.

A Prodrug Approach to Improve the Physico-Chemical Properties and Decrease the Genotoxicity of Nitro Compounds

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Automatic dimming multi-lamp fluorescent management system with active input power factor corrector stage

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Sistema automático para o controle eficiente de iluminação para multiplas lâmpadas fluorescentes

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise dos projetos ambientais desenvolvidos em um bairro de Bauru (SP) sob a perspectiva educativa

Pós-graduação em Educação para a Ciência - FC

Progress made in the implementation of the CARICOM single market and economy

Includes bibliography

Hypusine Modification of the Ribosome-binding Protein eIF5A, a Target for New Anti-Inflammatory Drugs: Understanding the Action of the Inhibitor GC7 on a Murine Macrophage Cell Line

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Futebol brasileiro: uma análise comparativa das fórmulas de disputa do campeonato brasileiro da série A nos últimos 15 anos (1995-2010)

In Brazil, the football is more than just a sport, it's a passion and part of country's DNA almost a century ago. By this prerogative the club national championship, nowadays known as Brazilian Championship and organized by Brazilian Football Confederation, it is a mark in this modality. During the soccer history, were made several changes of nomenclature, rules and dispute mode, that generated many controversies, contributing for discussing about credibility of the championship. There were many changes about dispute mode, alternating the mixed mode (eliminatory + classificatory and vice versa) and a dispute mode based on classification. This research aimed to described and to analyzed the changes that have occurred in dispute types of the Brazilian Championship, series A, in the last 15 years (1995 to 2010). It was analyzed each edition, with data like average of public, matches and participants number, period that the championship was conducted, beyond the dispute mode. In the last 15 years, have been used five different types and it was observed that the current mode to consecutive points is the most appropriate, because this mode showed the best public average, greater coherence to elect the competition champion and this mode also encouraged the clubs about planning, organization and professional management. This issues contributed to a significant improvement in quality of Championship

Os cadernos de física: algumas inquietações sobre o currículo oficial do Estado de São Paulo

The assumptions of Marxist philosophy helps us understand the inherent contradictions of the historical process. The category mode of production is understood as the means and the ends for which mankind produces and reproduces reality objectively and subjectively. The temporal evolution of the mode of production has spurred antagonistic social classes, which are the world capitalist bourgeoisie and proletariat. At the rise of the current mode of production each class produced a pedagogy according to your interests. The proposal of the workers is centered on unity between teaching and non-alienated labor, enabling the development of human potential and building a new social order. The last historical period was marked by the implementation of the neoliberal agenda to reduce social spending and market liberalization. The educational reforms of the state of São Paulo followed the same goals. From the program São Paulo Faz Escola, São Paulo School Curriculum was introduced in the State of São Paulo, which integrates several documents. The Student Notebook, separated by discipline and delivered bimonthly to students of public schools, is one of those publications. Specifically, the physics notebook brings a content with no depth, where theories are presented by minimizing the mathematical formalism for a broad education that meets the needs for dynamize the economy

A multi-objective adaptive immune algorithm for multi-application NoC mapping

Current SoC design trends are characterized by the integration of larger amount of IPs targeting a wide range of application fields. Such multi-application systems are constrained by a set of requirements. In such scenario network-on-chips (NoC) are becoming more important as the on-chip communication structure. Designing an optimal NoC for satisfying the requirements of each individual application requires the specification of a large set of configuration parameters leading to a wide solution space. It has been shown that IP mapping is one of the most critical parameters in NoC design, strongly influencing the SoC performance. IP mapping has been solved for single application systems using single and multi-objective optimization algorithms. In this paper we propose the use of a multi-objective adaptive immune algorithm (M(2)AIA), an evolutionary approach to solve the multi-application NoC mapping problem. Latency and power consumption were adopted as the target multi-objective functions. To compare the efficiency of our approach, our results are compared with those of the genetic and branch and bound multi-objective mapping algorithms. We tested 11 well-known benchmarks, including random and real applications, and combines up to 8 applications at the same SoC. The experimental results showed that the M(2)AIA decreases in average the power consumption and the latency 27.3 and 42.1 % compared to the branch and bound approach and 29.3 and 36.1 % over the genetic approach.