Desenvolvimento e aplicação de biomateriais à base de quitosana para reconstrução óssea: avaliação radiográfica e histológica

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Efeito do plasma rico em plaquetas associado ao enxerto autógeno na tíbia de coelhos: estudos histomorfométrico e biomecânico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo da ação local do alendronato sódico, da hidroxiapatita e da associação alendronato sódico com a hidroxiapatita, no reparo ósseo de fêmures de ratos

Pós-graduação em Biopatologia Bucal - ICT

Reparação óssea em fêmures de ratas ovariectomizadas sob a ação local do alendronato sódico, da hidroxiapatita e da associação alendronato com a hidroxiapatita

Pós-graduação em Biopatologia Bucal - ICT

Estudo comparativo dos efeitos da calcitonina e do plumbum metallicum 30ch na reparação óssea em mandíbula de ratos

Pós-graduação em Biopatologia Bucal - ICT

Avaliação do processo de reparo periimplantar utilizando matriz óssea heterógena desmineralizada ou osso autógeno: análise histológica e histométrica em tíbias de coelhos

Pós-graduação em Odontologia - FOA

Placas em ponte para tratamento de falhas segmentadas em mandíbulas de cães: projetos e desenvolvimento

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Utilização de plasma rico ou pobre em plaquetas, associado ou não a enxerto ósseo cortical alógeno, na reparação cirúrgica de falha ulnar em ovinos

Pós-graduação em Cirurgia Veterinária - FCAV

Efeitos da Calcarea phosphorica 6CH e do alendronato na reparação da lesão óssea em ratas ovariectomizadas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Efeito do Symphytum officinale L. (confrei) fitoterápico e homeopático na reparação óssea em tíbias de ratos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Aspecto radiológico e macroscópico de matriz óssea mineralizada heteróloga fragmentada e polimetilmetacrilato autoclavados em falha óssea de tíbia de coelho

A segmental defect of 6mm diameter was performed in the medial metaphyseal region of the tibia of 12 rabbits. For the bone defect reconstruction there was implanted a combination of micro and macro fragments of heterologous fragmented cortical bone matrix preserved in glycerin (98%) and polymethylmethacrylate, both autoclaved. Radiological and macroscopic evaluation was performed at 30, 60, 90 and 120 days. Adhesion in relation to time of the micro and macro composites to the recipient bed was observed in 100% of the cases. This showed that this implant is biologically biocompatible, since it promoted bone defects repair, with no signs of infection, migration and/or rejection. In this way, this implant can be classified as one more option of substitute to fill large bone defects.

Influência da calcitonina na regeneração óssea em mandíbulas de ratas ovariectomizadas

In This work we studied the action of calcitonin on bone regeneration in the jaws of normal and ovariectomized rats with and without administration of calcitonin. One hundred rats aged approximately sixty days were used for this study. Of these fifty were ovariectomizedOv forming group and one month after the surgery, animals in all a hundred surgical bone defect was made in the angle of the mandible, creating a bone lesion of approximately 4 mm, covered with a PTFE barrier. OvThe animals were divided into two equal groups: Ov (ovaricctomizados) and LMO (ovariectomized with calcitonin). The other fifty animals, only with the bone lesion were also divided into two groups: control (C) and CM (control with calcitonin). Treated groups received the first dose of the substance immediately after surgery, the dose of 2 IU / kg IM three times per week. The animals were sacrificed after three, seven, 14, 21 and 28 days, with their jaws removed and sent for histological preparation. Densitometric analyzes were performed histological and histomorphometric verifying that it was observed that the Ov animals showed decreased bone density and a much slower regenerative process, when compared with control animals. Calcitonin proved effective in both ovariectomized animals and in those with only bone injury.

Avaliação histológica do processo de reparação do tecido ósseo do rato frente à aplicação de um adesivo à base de cianoacrilato

This research objective was to verify the tissues reactions obtained, in surgical experimental bone defect, after the etil cyanoacrylate chemical adhesive application in rats parietal bones. 1t was investigated the acceptance or no acceptance of the tissues surround the bone defect in which was placed the etil cyanoacrylate and the control bone defect. The specimens were submitted to light microscopic analysis. 24 adults rats were used (Rattus norvergicus, albinus, Wistar) with the average weight to 300 gr. and were divided in two groups: treated and control. After the bone defects were realized, etil cyanoacrylate was placed over one of the defects at the parietal bone (treated group). On the other defect nothing was placed and it was used like control group. After 24 hours, 3,5,7,30 and sixty days after surgery, for animals of each group were sacrificed. The bone samples were removed and fixed in 10% formalin during 72 hours and analyzed using light microscopy. The results showed that the acute inflammatory responses was more observed at lhe treated group than the control group. The chemical adhesive was observed until 60 days follow the surgery and the tissues around it present normal appearance. The chemical adhesive, etil cyanaocrylate, did not impede at the bone repair process

Influência da sinvastatina na reparação óssea de mandíbulas da ratas ovariectomizadas e nos níveis de colesterol sanguíneo

Pós-graduação em Biopatologia Bucal - ICT

Caracterização radiográfica ex vivo de biomateriais utilizados para regeneração óssea em mandíbulas de porcos

Introduction: The radiographic characteristics of a biomaterial, such as its density, may influence the evaluation of the results obtained following its clinical use. Objective: The aim of this study was to evaluate the radiographic density of biomaterials used as bone substitutes, inserted into dental sockets and bone defects in created in the jaws of pigs. The influence of a soft tissue simulator on the results was also evaluated. Material and method: Two and three-millimeter-deep bone defects were created in the pigs mandible and the right first molar extraction socket were used. Commercial samples of five biomaterials were tested: Hydroxyapatite, Lyophilized Bovine Bone, 45S5 bioglass (generic), PerioGlass and β-Tri-Calcium Phosphate, and compared to a positive (mandibular bone) and negative (empty alveolar bone defects) controls. Radiographic images were acquired with and without a 10 mm thick soft-tissue simulator. Result: The results for the extraction sockets showed no differences between the biomaterials and the negative control. For the bone defects, the depth of the defect density influenced the density, both in the negative control (p < 0.01) and biomaterials (p < 0.05) groups. The soft- tissue simulator did not alter the results. Conclusion: The type of the evaluated defect can interfere in the radiographic features presented by each biomaterial, while the simulation of soft tissues was not statistically significant.