452 resultados para bk: ilissAfrica


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Summary: Cut! : political film censorship in Finland, 1939-1947

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Doctoral dissertation, University of Tampere

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Summary: Unsuited to educate children! : attempted political purges of teachers in Finland from 1944-1948

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Summary: An "Old Finn" in the Agrarian Union : Jalo Lahdensuo's ideals and work in public life

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Doctoral dissertation, University of Tampere

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English summary: Efficient business activity in small Ostrobothnian towns : profitability and productivity of shipping by sail during the eighteenth and nineteenth century

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Doctoral dissertation, University of Turku

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Summary: A difficult freedom : social democracy's defeat to the church in the Finnish cultural struggle

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Summary: A law nailed down with force : the shutting down of labour halls in 1929-1932

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BACKGROUND: Polyomavirus-associated nephropathy (PVAN) is a serious complication and cause of graft loss in kidney transplant recipients. In the absence of specific antiviral drugs, early detection of the disease and reduction of immunosuppressive regimen is the cornerstone of therapy. Cidofovir, a nucleoside analogue, has been found to inhibit BK virus (BKV) replication in vitro and has been proposed as treatment of refractory PVAN at low doses; however, its efficacy has never been demonstrated in randomized controlled trials. METHODS: Cidofovir therapy (0.5 mg/kg at a 2-week interval for eight consecutive doses) was initiated in two patients with biopsy-proven PVAN and persistent BKV DNA viraemia (> or = 10,000 copies/ml despite sustained reduction of the immunosuppressive regimen). In addition to these two case reports, we performed a critical review of the literature on the use of cidofovir in PVAN. RESULTS: No significant decrease of BKV viral load in blood was observed during cidofovir therapy and in follow-up of the two patients treated with cidofovir. Our literature review identified 21 publications reporting the use of cidofovir for the treatment of PVAN. All were case reports or small series. The efficacy of cidofovir therapy could not be assessed in 17 of these publications because of lack of data or concomitant reduction of immunosuppressive regimen. The four remaining publications were case reports. CONCLUSIONS: In vitro and clinical data to support the efficacy of cidofovir in the treatment of PVAN are currently lacking. More promising compounds should be identified for further clinical studies.

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Summary: The discovery of Chairman Mao in Finland in the 1960s

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Väitöskirja, Tampereen yliopisto