FWS/0BS.

77/16.2

FWS/0BS.

77/16.4

FWS/0BS.

77/15

FWS/0BS.

7703

FWS/0BS.

80/09

FWS/0BS.

82/20

FWS/0BS.

77/16.3

FWS/0BS.

78/80

FWS/0BS.

85(7.2)

Evaluation des campagnes de prévention contre le SIDA en Suisse : Les éducateurs et assistants sociaux : rôle de conseillers dans la prévention et l'accompagnement : rapport final 1988

Dans le cadre de l'évaluation de la campagne STOP-SIDA, les auteurs avaient pour but d'examiner: 1) l'influence et l'intégration des messages préventifs dans la pratique professionnelle des travailleurs sociaux chargés de missions diverses avec les adolescents; 2) le poids de l'épidémie de SIDA dans les pratiques de ceux qui affrontent déjà le problème; 3) l'émergence de demandes particulières, formatives ou matérielles, pour aider à l'accompagnement de jeunes séropositifs ou de malades; 4) les difficultés et les blocages de l'action préventive dus à des conflits de rôles, à des contradictions entre discours professionnels et pratiques personnelles. ANNEXE: Questionnaire envoyé aux institutions. Guide d'entretien.

Comparison between a high-resolution single-stage Orbitrap and a triple quadrupole mass spectrometer for quantitative analyses of drugs.

The capabilities of a high-resolution (HR), accurate mass spectrometer (Exactive-MS) operating in full scan MS mode was investigated for the quantitative LC/MS analysis of drugs in patients' plasma samples. A mass resolution of 50,000 (FWHM) at m/z 200 and a mass extracted window of 5 ppm around the theoretical m/z of each analyte were used to construct chromatograms for quantitation. The quantitative performance of the Exactive-MS was compared with that of a triple quadrupole mass spectrometer (TQ-MS), TSQ Quantum Discovery or Quantum Ultra, operating in the conventional selected reaction monitoring (SRM) mode. The study consisted of 17 therapeutic drugs including 8 antifungal agents (anidulafungin, caspofungin, fluconazole, itraconazole, hydroxyitraconazole posaconazole, voriconazole and voriconazole-N-oxide), 4 immunosuppressants (ciclosporine, everolimus, sirolimus and tacrolimus) and 5 protein kinase inhibitors (dasatinib, imatinib, nilotinib, sorafenib and sunitinib). The quantitative results obtained with HR-MS acquisition show comparable detection specificity, assay precision, accuracy, linearity and sensitivity to SRM acquisition. Importantly, HR-MS offers several benefits over TQ-MS technology: absence of SRM optimization, time saving when changing the analysis from one MS to another, more complete information of what is in the samples and easier troubleshooting. Our work demonstrates that U/HPLC coupled to Exactive HR-MS delivers comparable results to TQ-MS in routine quantitative drug analyses. Considering the advantages of HR-MS, these results suggest that, in the near future, there should be a shift in how routine quantitative analyses of small molecules, particularly for therapeutic drugs, are performed.

05007-003 Hewitt Creek Watershed Final Report

The goal of this project is to help residents of the Hewitt Creek watershed identify themselves as a watershed community and use cost-effective approaches to control non-point source nutrient and sediment contaminants according to collective science-based environmental goals. The project will tap the low-cost, high-return human resources of local knowledge and resident leadership for economical and sustainable solutions. A watershed council will implement an incentive program to engage their watershed community in locally-acceptable practices and performance (outcome) measures for environmental stewardship that have reasonable cost and are linked with accountable crop and livestock management decisions. The Iowa and Dubuque County Farm Bureau have supported one year of management practice incentives. The performance incentive program will take this effort to the next level, to focus on outcomes.

05037-014 Elk River Watershed Final Report

The Watershed Improvement Review Board (WIRB) Grant will be used to enhance an on-going water quality project in Elk River Watershed. A targeted, locally controlled project has been active in the watershed since 2001. Current funding is being received primarily from the EPA-319 program, administrated by IDNR and the Watershed Protection Fund (WSPF) administrated by IDALS-DSC. Substantial funding is also obtained from the yearly county allocation of the Environmental Quality Incentive Program (EQIP) administrated by the USDA-NRCS. The overall objective of the Elk River Water Quality Project is to improve and restore the water quality in this water body by keying in on the potential sources of the identified impairments, and forging a working partnership between the local residents and the conservation agencies and organizations involved in the project. The major potential sources of the known surface water quality problems were identified during the assessment process and pointed to feedlot runoff and sediment delivery from within priority sub-watersheds. WIRB Funds will be used to cost share the application of Best Management Practices, thus reducing the projects dependency on federal funds. Funds will also be used to overcome a project’s limiting factor associated with insufficient technical assistance.