Stereoselective synthesis of 8,9-licarinediols

The total synthesis of 8,9-licarinediols was selectively carried out from licarin A, previously obtained by oxidative coupling of (E)-isoeugenol. The corresponding enantiomerically pure (+)- and(-)-licarin A ester derivatives were subjected to Sharpless oxidation to yield the asymmetric C-8, C-9 dihydroxylation products, whose absolute configurations were established by means of the CD and NMR spectroscopic analyses of their Mosher ester derivatives. (C) 2000 Elsevier B.V. Ltd. All rights reserved.

Effect of reduced myristoylated alanine-rich C kinase substrate expression on hippocampal mossy fiber development and spatial learning in mutant mice: Transgenic rescue and interactions with gene background

The myristoylated alanine-rich C kinase substrate (MARCKS) is a prominent protein kinase C (PKC) substrate in brain that is expressed highly in hippocampal granule cells and their axons, the mossy fibers. Here, we examined hippocampal infrapyramidal mossy fiber (IP-MF) limb length and spatial learning in heterozygous Macs mutant mice that exhibit an ≈50% reduction in MARCKS expression relative to wild-type controls. On a 129B6(N3) background, the Macs mutation produced IP-MF hyperplasia, a significant increase in hippocampal PKCɛ expression, and proficient spatial learning relative to wild-type controls. However, wild-type 129B6(N3) mice exhibited phenotypic characteristics resembling inbred 129Sv mice, including IP-MF hypoplasia relative to inbred C57BL/6J mice and impaired spatial-reversal learning, suggesting a significant contribution of 129Sv background genes to wild-type and possibly mutant phenotypes. Indeed, when these mice were backcrossed with inbred C57BL/6J mice for nine generations to reduce 129Sv background genes, the Macs mutation did not effect IP-MF length or hippocampal PKCɛ expression and impaired spatial learning relative to wild-type controls, which now showed proficient spatial learning. Moreover, in a different strain (B6SJL(N1), the Macs mutation also produced a significant impairment in spatial learning that was reversed by transgenic expression of MARCKS. Collectively, these data indicate that the heterozygous Macs mutation modifies the expression of linked 129Sv gene(s), affecting hippocampal mossy fiber development and spatial learning performance, and that MARCKS plays a significant role in spatial learning processes.

On the measurement of correlation with special reference to some characters of Indian corn [abstract] /

Cover title.

The case of the German Jews vs. Germany; a legal basis for the claims of the German Jews against Germany,

Bibliography: p. 119-124.

Mathematics of finance,

Mode of access: Internet.

A plea for the supremacy of Christ as the king and head of his own church in two sermons, preached in the Presbyterian Church, (Old School) Madison, Wis., March 18, 1860 /

These sermons are a response to the exclusion of slaveowners from communion. The author states why he opposes this practice and interprets New Testament passages on slavery.

En les landes.

Mode of access: Internet.

Hell-hole of creation; the exploration of Abyssinian Danakil.

"First American edition."

The Tasmanian law reports : cases determined in the Supreme Court of Tasmania.

Earlier reports in: Reports of cases determined in the Supreme Court of Tasmania / Herbert Nicholls and W. J. T. Stops.

Reports of cases determined in the Supreme Court of Judicature of the State of New Jersey.

Publisher and place of publication vary.

Bibliographie générale des inventaires imprimés,

The "Tables" announced in the publisher's catalog as t. II, fasc. II, have signature t. III.

A digest of the law of easements /

Mode of access: Internet.

Relation of the discovery and conquest of the kingdoms of Peru /

Reprint. Originally published: New York : The Cortes Society, 1921, in series: Documents and narratives concerning the discovery and conquest of Latin America ; no. 4, v. 1.