The Man in the moon. Consisting of essays and critiques on the politics, morals, manners, drama, &c. of the present day ... [no. 1-24; Nov. 12, 1803-Jan. 28 [i.e. Feb. 11] 1804]

"By Will. Smelley."-Catalogue of a collection of early newspapers and essayists formed by the late J.T. Hope. no. 564.

The new American practical navigator : being an epitome of navigation; containing all the tables necessary to be used with the nautical almanac, in determining the latitude, and the longitude by lunar observations, and keeping a complete reckoning at sea; illustrated by proper rules and examples ... dictionary of sea terms; and the manner of performing the most useful evolutions at sea: : with an appendix, containing methods of calculating eclipses of the sun and moon, and occultations of the fixed stars ... /

Three pages at end contain a publishers' advertisement.

Margetts's Longitude tables for correcting the effects of parallax and refraction, on the observed distance taken between the moon and the sun or a fixed star ... and the corresponding time at Greenwich, found by inspection.

Mode of access: Internet.

The new American practical navigator : being an epitome of navigation; containing all the tables necessary to be used with the Nautical almanac, in determining the latitude and the longitude by lunar observations; and keeping a complete reckoning at sea ... The whole exemplified in a journal kept from Boston to Madeira ... With an appendix, containing methods of calculating eclipses of the sun and moon, and occultations of the fixed stars /

Campbell 10. First issue with plates dated 1826.

Historic background and annals of the Swiss and German pioneer settlers of southeastern Pennsylvania, and of their remote ancestors, from the middle of the dark ages, down to the time of the revolutionary war; an authentic history, from original sources ... with particular reference to the German-Swiss Mennonites or Anabaptists, the Amish and other nonresistant sects.

Mode of access: Internet.

Through the Dark Continent : or, The sources of the Nile around the Great Lakes of equatorial Africa and down the Livingstone River to the Atlantic Ocean /

Includes index.

A pearl in dark waters : a tale of the times of blessed Margaret Mary.

Mode of access: Internet.

The moon out of reach,

Mode of access: Internet.

The wild garden : or, our groves and gardens made beautiful by the naturalisation of hardy exotic plants; being one way onwards from the dark ages of flower gardening, with suggestions for the regeneration of the bare borders of the London Parks, /

Includes index.

A flight to the moon, or, The vision of Randalthus /

Shaw & Shoemaker

From flying horse to man in the moon; a history of flight from it earliest beginnings to the conquest of space.

Mode of access: Internet.

Heroes of the dark continent : and how Stanley found Emin Pasha : a complete history of all the great explorations and discoveries in Africa, from the earliest ages to the present time.

Mode of access: Internet.

Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague-Dawley rats: Influence of streptozotocin-induced diabetes

Purpose. The aims of this study are to evaluate whether cytochrome P450 (CYP)2D1/2D2-deficient dark agouti (DA) rats and/or CYP2D1/2D2-replete Sprague-Dawley (SD) rats are suitable preclinical models of the human, with respect to mirroring the very low plasma concentrations of metabolically derived oxymorphone seen in humans following oxycodone administration, and to examine the effects of streptozotocin-induced diabetes on the pharmacokinetics of oxycodone and its metabolites, noroxycodone and oxymorphone, in both rodent strains. Methods. High-performance liquid chromatography-electrospray ionization-tandem mass spectrometry was used to quantify the serum concentrations of oxycodone, noroxycodone, and oxymorphone following subcutaneous administration of bolus doses of oxycodone (2 mg/kg) to groups of nondiabetic and diabetic rats. Results. The mean (+/- SEM) areas under the serum concentration vs. time curves for oxycodone and noroxycodone were significantly higher in DA relative to SD rats (diabetic, p < 0.05; nondiabetic, p < 0.005). Serum concentrations of oxymorphone were very low (< 6.9 nM). Conclusions. Both DA and SD rats are suitable rodent models to study oxycodone's pharmacology, as their systemic exposure to metabolically derived oxymorphone (potent mu-opioid agonist) is very low, mirroring that seen in humans following oxycodone administration. Systemic exposure to oxycodone and noroxycodone was consistently higher for DA than for SD rats showing that strain differences predominated over diabetes status.