Bibliotheca arabico-hispana escurialensis : sive Librorum omnium Mss. quos Arabice ab auctoribus magnam partem Arabo-Hispanus compositos Bibliotheca coenobii Escurialensis complectitur recensio & explanatio

Sign.: [A]-B4, A-F1/3, A-2Z4, 3A-3Y4

Genetic and comparative analyses reveal an alternative secondary structure in the region of nt 912 of Escherichia coli 16S rRNA.

Mutations at position 912 of Escherichia coli 16S rRNA result in two notable phenotypes. The C-->U transition confers resistance to streptomycin, a translational-error-inducing antibiotic, while a C-->G transversion causes marked retardation of cell growth rate. Starting with the slow-growing G912 mutant, random mutagenesis was used to isolate a second site mutation that restored growth nearly to the wild-type rate. The second site mutation was identified as a G-->C transversion at position 885 in 16S rRNA. Cells containing the G912 mutation had an increased doubling time, abnormal sucrose gradient ribosome/subunit profile, increased sensitivity to spectinomycin, dependence upon streptomycin for growth in the presence of spectinomycin, and slower translation rate, whereas cells with the G912/C885 double mutation were similar to wild type in these assays. Comparative analysis showed there was significant covariation between positions 912 and 885. Thus the second-site suppressor analysis, the functional assays, and the comparative data suggest that the interaction between nt 912 and nt 885 is conserved and necessary for normal ribosome function. Furthermore, the comparative data suggest that the interaction extends to include G885-G886-G887 pairing with C912-U911-C910. An alternative secondary structure element for the central domain of 16S rRNA is proposed.

Second St. Gallen European Organisation for Research and Treatment of Cancer Gastrointestinal Cancer Conference: consensus recommendations on controversial issues in the primary treatment of rectal cancer

Primary treatment of rectal cancer was the focus of the second St. Gallen European Organisation for Research and Treatment of Cancer (EORTC) Gastrointestinal Cancer Conference. In the context of the conference, a multidisciplinary international expert panel discussed and voted on controversial issues which could not be easily answered using published evidence. Main topics included optimal pretherapeutic imaging, indication and type of neoadjuvant treatment, and the treatment strategies in advanced tumours. Here we report the key recommendations and summarise the related evidence. The treatment strategy for localised rectal cancer varies from local excision in early tumours to neoadjuvant radiochemotherapy (RCT) in combination with extended surgery in locally advanced disease. Optimal pretherapeutic staging is a key to any treatment decision. The panel recommended magnetic resonance imaging (MRI) or MRI + endoscopic ultrasonography (EUS) as mandatory staging modalities, except for early T1 cancers with an option for local excision, where EUS in addition to MRI was considered to be most important because of its superior near-field resolution. Primary surgery with total mesorectal excision was recommended by most panellists for some early tumours with limited risk of recurrence (i.e. cT1-2 or cT3a N0 with clear mesorectal fascia on MRI and clearly above the levator muscles), whereas all other stages were considered for multimodal treatment. The consensus panel recommended long-course RCT over short-course radiotherapy for most clinical situations where neoadjuvant treatment is indicated, with the exception of T3a/b N0 tumours where short-course radiotherapy or even no neoadjuvant therapy were regarded to be an option. In patients with potentially resectable tumours and synchronous liver metastases, most panel members did not see an indication to start with classical fluoropyrimidine-based RCT but rather favoured preoperative short-course radiotherapy with systemic combination chemotherapy or alternatively a liver-first resection approach in resectable metastases, which both allow optimal systemic therapy for the metastatic disease. In general, proper patient selection and discussion in an experienced multidisciplinary team was considered as crucial component of care.

Die Empörung der Sklaven von Sankt Domingo : (Bug-Jargal) /

Mode of access: Internet.

Geschichte und merkwürdigkeiten der Stiftsbibliothek in Zeiz. Als einladung zu einer redeübung in der Stiftsschule zu Zeiz den 16. may 1808.

Mode of access: Internet.

A check-list and index of microfilm M-75, Dr. Alfred Einstein's mss. at Smith College, Mass. /

Cover title: Einstein (Alfred) mss. at Smith College : a checklist & index.

The Wheatley manuscript : a collection of Middle English verse and prose contained in a ms. now in the British museum. Add. mss. 39574 /

Fifteenth century manuscript named in honor of Dr. H.B. Wheatley.

King Horn : with fragments of Floriz and Blancheflur, and of the Assumption of Our Lady : from a MS (GG. 4.27.2) in the Cambridge University Library : also from MSS. in the British Museum The Assumption of Our Lady (A.D. MSS. 10036), and Fragments of the Floyres and Blanchefleur (Cotton Vitelluis D.111) /

Includes glossarial index.

Treasures of art in Great Britain : being an account of the chief collections of paintings, drawings, sculptures, illuminated mss., &c. &c. /

Supplemented by: "Summary of an index to Waagen, by Algernon Graves" ([9], 366 p., plate. port. 25 cm.) published: London, Cornmarket, 1970. Facsim. of 1912 ed.

Omnibus judgeship bill. Report to accompany S. 912.

Mode of access: Internet.