滇东南南温河花岗岩年代学和地球化学初步研究

南温河花岗岩分布于中-越接壤处的云南省马关县、麻栗坡县老君山地区穹隆状变形-变质岩系的内核部位，大地构造位置位于华南褶皱带西端与上扬子地块、哀牢山褶皱带和印支地块的接合部位，是研究华南大陆形成与演化及特提斯构造域时空发展的关键地区。前人对本地区花岗岩的研究，更多的集中在燕山期老君山花岗岩的研究上，而对南温河花岗岩的研究还没有引起足够的重视，还停留在初步的岩石学和地球化学阶段。 本文对滇东南老君山地区南温河花岗岩进行了U-Pb、Rb-Sr同位素年代学和主微量、Sr-Nd同位素地球化学的系统研究，取得了以下主要认识： 1、通过对南温河花岗岩 SHRIMP锆石U-Pb、TIMS锆石U-Pb年代学和全岩Rb-Sr年代学的研究，确定了南温河花岗岩主体的结晶年龄为440Ma左右，少量结晶为420Ma左右， 属于广西运动产物。在同位素年代学和岩石学研究基础上，重新对南温河花岗岩进行了岩石单元划分，归并为猛洞河单元和南加河单元两个单元。南捞片麻岩并非如1：50000麻栗坡县幅、都龙幅所认为的新元古代岩浆岩，也同属加里东期岩浆岩，应归属于猛洞河单元。 2、南温河序列花岗岩成分来源主要为上部地壳的泥质岩、粉砂岩、杂砂岩的部分熔融，可能还有少量地幔物质和下部地壳物质的加入。成因上主要属于S型花岗岩，少量属于 I型花岗岩。 形成的构造环境上，主要为同碰撞环境，少部分为造山后环境。 继承锆石年龄和Sr-Nd同位素地球化学特征显示，源区存在古元古代的古老地壳。 3、结合SHRIMP和TIMS锆石U-Pb年代学两种测年方法的差异，确定了后期的主变质年龄为 230Ma左右，提出了确定后期中-浅变质作用年龄的一种新思路。 4、通过南温河花岗岩热年代史反演，恢复了本区加里东期以来的构造历史，并初步探讨了本区加里东期的大地构造环境。

山东地区中生代岩浆作用与地壳拉张-兼论煌斑岩与金成矿的关系

燕山期（205～65Ma）山东地区地壳活动强烈，构造体系已由古亚洲构造域完全转化为滨太平洋构造域，构造活动导源于太平洋板块对欧亚板块的俯冲。由于太平洋板块对欧亚板块的俯冲（NW向），鲁东地区岩石圈发生了快速拆沉减薄作用．同时鲁东地区也可能会出现地l漫柱的活动；另外，在太平洋板块俯冲作用影响下，炎区庐断裂（山东称沂沐断裂）带发生了大型左行走滑剪切和拉张活动。以上构造因素加上早白至世末一晚白至世期间燕山造山带的垮塌，都可能为山东地区中生代地壳拉张提供了动力条件。山东地区中生代（燕山期）基性脉岩特别发育，这些慢源基性岩脉充填张性裂隙，是大陆地壳拉张的标志；另外，山东地区也存在大量拉张背景下的燕山期火山岩和碱性岩。但关于它们的年代学和系统的地球化学研究还比较薄弱，且对其成因和形成的构造环境，仍存在着争议。本论文主要从同位素年代学、岩石化学、地球化学和Sr-Nd-Pb同位素方面对山东地区燕山期基性脉岩、火山岩和碱性超基性脉岩进行了系统研究。同时，考虑到鲁东地区煌斑岩中金含量普遍较高，且燕山期又是山东金矿的主成矿期，论文中对煌斑岩与金成矿之间的关系也作了一定的研究。通过研究，得出以下主要认识：1、火山岩为一套以钙碱性安山岩为主，含少量拉斑玄武岩和英安岩。成因上为富集地慢部分熔融作用的结果，但在成岩过程中也可能存在单斜辉石、斜长石、橄榄石和Ti-Fe氧化物等矿物的分离结晶作用。碱性超基性脉岩岩性上为单一的橄榄辉石岩，为富集地慢源低度（3.4％）部分熔融作用的产物，岩浆演化过程经历了以橄榄石为主的分馏作用。基性脉岩主要包括辉长岩、辉绿岩（主要分布在鲁西地区）和煌斑岩（以斜闪煌斑岩为主，同时含部分拉辉煌斑岩和角闪煌斑岩）（主要分布在鲁东地区），都为富集岩石圈地慢部分熔融的产物。三类岩石在侵位结晶过程都不存在明显的地壳混染。2、火山岩、碱性超基性脉岩和基性脉岩（除少数外）都形成于大陆板内拉张环境。3、富集地慢源区（EMI）的产生是俯冲并熔融的扬子下地壳物质进入华北岩石圈地慢并与之相互交代作用形成的。4、研究区中生代基性脉岩K-Ar年龄分布范围为72.2±1.70Ma～204.2±5.4Ma，且基本上在90～140Ma之间变化。综合碱性超基性脉岩和已知的青山组的火山岩、基性脉岩年龄数据，认为山东地区中生代地壳拉张至少存在四次：即约80Ma、100Ma、120Ma和 140Ma。但鲁东地区在地壳拉张方面可能存在着与鲁西地区不同的制约因素：即鲁东地区存在拆沉作用和可能存在地慢柱的影响，而鲁西地区可能受到了郊庐断裂的左行走滑剪切和拉张活动的影响。5、胶北地区煌斑岩为钙碱性系列，且金含量普遍较高（平均28ppb），该研究对胶北地区的找矿勘探工作具有一定意义。

Suplementação com Vitamina D e seus derivados na prevenção e tratamento do cancro da próstata

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas

Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors.

In our continuing study of triterpene derivatives as potent anti-HIV agents, different C-3 conformationally restricted betulinic acid (BA, 1) derivatives were designed and synthesized in order to explore the conformational space of the C-3 pharmacophore. 3-O-Monomethylsuccinyl-betulinic acid (MSB) analogues were also designed to better understand the contribution of the C-3' dimethyl group of bevirimat (2), the first-in-class HIV maturation inhibitor, which is currently in phase IIb clinical trials. In addition, another triterpene skeleton, moronic acid (MA, 3), was also employed to study the influence of the backbone and the C-3 modification toward the anti-HIV activity of this compound class. This study enabled us to better understand the structure-activity relationships (SAR) of triterpene-derived anti-HIV agents and led to the design and synthesis of compound 12 (EC(50): 0.0006 microM), which displayed slightly better activity than 2 as a HIV-1 maturation inhibitor.

Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT2/5-HT3/5-HT4 ligands

The present study examined the effects of administering selective 5-HT antagonists and agonists to rats tested in the elevated zero-maze (EZM) model of anxiety. The EZM paradigm has advantages over the elevated plus-maze (EPM) paradigm with respect to measuring anxiety, yet has been utilized less frequently. Three experiments were conducted each with a diazepam control (0.25, 0.5 and 0.75 mg/kg). In the first experiment, we administered the 5-HT_2C antagonist RS 102221 (0.5, 1.0, and 2.0 mg/kg) and 5-HT_2C agonist MK-212 (0.25, 0.5 and 0.75 mg/kg); in the second experiment, we administered the 5-HT₃ antagonist Y-25130 (0.1, 1.0 and 3.0 mg/kg) and 5-HT₃ agonist SR 57227A (0.1, 1.0 and 3.0 mg/kg), and in the third experiment, we administered the 5-HT₄ antagonist RS 39604 (0.01, 0.1, 1.0 mg/kg) and 5-HT₄ agonist RS 67333 (0.01, 0.1 and 0.5 mg/kg). The administration of 5-HT_2/3/4 subtype antagonists all generated behavioral profiles indicative of anxiolytic-like effects in the EZM, which was apparent from examination of both traditional and ethological measures. While little effect was observed from 5-HT₂ and 5-HT₃ agonists, the 5-HT₄ agonist RS 67333 was found to produce a paradoxical anxiolytic-like effect similar to that produced by the 5-HT₄ antagonist RS 39604. We conclude by discussing the implications of these findings.

Aplicação de técnicas de conservação in vitro para a conservação de espécies ameaçadas

Dissertação mest., Engenharia Biológica, Universidade do Algarve, 2008

Mémoires de la Société impériale des antiquaires de France

Variante(s) de titre : Mémoires de la Société nationale des antiquaires de France (1852)

Systematic studies of the effect of pressure on magnetic and electronic properties of La2/3Ca1/3MnO3 thin films with various thicknesses /

Interest in mixed-valent perovskite manganese oxides of La\-xAxMnO^ (v4-divalent alkaline earth Ca, Sr or Ba), whose unusual properties were discovered nearly a half century ago, has recently been revived. The discovery of the colossal magnetoresistance and pressure effects introduced new questions concerning the complex interplay between lattice structure, magnetism and transport in doped perovskite manganites. In this study, we report our experimental investigations of pressure and magnetic field dependencies of La-i/sCai/sMnOs (LCMO) epitaxial films with various thickness on SrTiO$ substrate. An analysis of film thickness dependency of the resistivity of LCMO epitaxial films under pressure and magnetic field has been performed by taking into account substrate contributions. This verifies the correlation of lattice distortion with magnetic and transport properties. Strong dependencies of Mn — O — Mn bond bending and Mn — O bond stretching with pressure as well as Mn spin alignment with magnetic field, and the lattice distortion induced by the substrate are discussed.

Geochemistry and petrogenesis of the Proterozoic Pater metavolcanic suite, Spragge, Ontario /

The Pater metavolcanic suite (PVS) was extruded as part O'f the basal Pater Formation of the Huronian Supergroup ca. 2.4 Ga. They Ars classified as wi thin-plate tholeiites associated with an immature ri-fting episode, and are inter layered with associated vol cani clastic and metasedimentary units. Post-solidif ication alteration caused redistribution o-f the alkalies, Sr, Rb, Ba, Cu, and SiO^. Ce, Y, Zr, CFezOs (as total Fe), Al^Os, TiOa, and, PaOa are considered to have remained essentially immobile in least altered samples. Petrogenetic modelling indicates the PVS was derived from the partial melting of two geochemical ly similar sources in the sub-continental lithosphere. Fractionation was characterized by an oli vine-plagioclase assemblage and a sub-volcanic plagioclase-clinopyroxene assemblage. A comparative study indicates that enrichment of the postulated Huronian source cannot be reconciled by Archean contamination. Enrichment is thought to have been caused by hydrous veined metasomatic heterogeneities in the sub-continental lithosphere, generated by an Archean subduct ion event before 2.68 Ga.

Anaerobic performance in ice hockey : the effect of skate blade radius of hollow

The purpose of the study was to investigate the effect of skate blade radius of hollow (ROH) on anaerobic performance, specifically during the acceleration and stopping phases of an on-ice skating test. Fifteen, male Junior B hockey players (mean age 19 y ± 1.46) were recruited to participate. On-icc testing required each participant to complete an on-ice anaerobic performance test [Reed Repeat Skate (RRS)) on three separate days. During each on-ice test, the participant's skate blades were sharpened to one of three, randomly assigned, ROH values (0.63 cm, 1.27 cm, 1.90 cm). Performance times were recorded during each RRS and used to calculate anaerobic variables [anaerobic power (W), anaerobic capacity (W), and fatigue index (s, %)). Each RRS was video recorded for the purpose of motion analysis. Video footage was imported into Peak Motus™ to measure kinematic variables of the acceleration and stopping phases. The specific variables calculated from the acceleration phase were: average velocity over 6 m (m/s), average stride length (m), and mean stride rate (strides/s). The specific variables calculated from the stopping phase were: velocity at initiation of stopping (rn/s), stopping distance (m), stopping time (s). A repeated measures ANOV A was used to assess differences in mean performance and kinematic variables across the three selected hollows. Further analysis was conducted to assess differences in trial by trial performance and kinematic variables for all hollows. The primary findings of the study suggested that skate blade ROH can have a significant effect on kinematic variables, namely stride length and stride rate during the acceleration phase and stopping distance and stopping time during the stopping phase of an on-ice anaerobic performance test. During the acceleration phase, no significant difdifferences were found in SR and SL across the three selected hollows. Mean SR on the 1.27 cm hollow was significantly slower than both the 0.63 cm and 1.90 cm hollows and SL was significantly longer when skating on the 1.27 cm hollow in comparison to the 1.90 cm hollow. During the stopping phase, stopping distance on the 0.63 cm hollow (4.12 m ± 0.14) was significantly shorter than both the 1.27 cm hollow (4.43 m ± 0.08) (p < 0.05) and the 1.90 cm ho])ow (4.35 m ± 0.12) (p < 0.05). Mean ST was also significantly shorter when stopping on the 0.63 cm hollow then both the 1.27 cm and 1.90 cm hollows. Trial by trial results clearly illustrated the affect of fatigue on kinematic variables; AV, SR, IV decreased from trial 1 to 6. There was no significant effect on anaerobic performance variables during the RRS. Altering the skate blade ROH has a significant and practical affect on accelerating and stopping performance will be discussed in this paper.

Los universitarios extremeños ante la Unión Europea : análisis de conocimientos y actitudes.

Conocer el grado de información, compromisos y actitudes de los estudiantes de la Universidad de Extremadura en relación con la Unión Europea. Se realizaron 675 encuestas a estudiantes de la Universidad de Extremadura en sus cuatro campus (Badajoz, Cáceres, Mérida, Plasencia) y en el Centro Cultural Santa Ana de Almendralejo. El cuestionario cuenta con 65 preguntas principales, incluyendo algunas de ellas sus propias baterías de preguntas secundarias. Se han procesado 104 ítems. La mayoría de las cuestiones son homologables a los eurobarómetros y otras encuestas actitudinales realizadas en la Unión Europea, con el fin de realizar comparaciones. Se incluyen cuestiones relativas a las características socioeconómicas de los estudiantes. La muestra seleccionada permite hacer comparaciones de los niveles de información y actitudes atendiendo a una serie de variables fundamentales: campus, tipo de carrera, edad, sexo, nivel socioeconómico, etc.. La autovaloración que los alumnos hacen de su conocimiento de la UE es baja, aunque su nivel es más elevado que en el conjunto de la UE y de España. Se pone de manifiesto la importancia de los medios de comunicación para tener más conocimientos y se muestra de forma generalizada interés por los asuntos de la UE. Aún existe mucho desconocimiento tal y como se desprende del bajo nivel de aciertos en cinco preguntas de asuntos de actualidad de la UE. Uno de cada tres alumnos ha seguido algún curso relacionado con la UE. Se pone de manifiesto un amplio talante europeista y se valora positivamente la pertenencia de España a la UE, considerando que Extremadura se ha beneficiado de la integración. Los principales problemas comunes a los Estados miembros que preocupan a los alumnos son, por un lado los relacionados con intereses locales o personales, y por otro, por los problemas de tipo social. Las acciones prioritarias que debe realizar la UE son las relacionadas con temas sociales (lucha contra la pobreza y desigualdad) y de seguridad (lucha contra tráfico de drogas, etc.). Se muestran bajos niveles de aceptación a la hora de ceder competencias de los Estados miembros a las instituciones comunitarias. La implantanción de la moneda única entusiasma a los universitarios, aunque se manifiestan dudas sobre las ventajas y riesgos de su instauración. La ampliación de la UE es aceptada favorablemente, pero se teme que pueda tener consecuencias negativas para España.

La formación permanente del profesorado de Educación Primaria en Cáceres (1986-1996) y su incidencia en el desarrollo profesional.

Estudio que tiene como propósito primordial conocer la formación permanente del profesorado de Educación Primaria en el ámbito del Centro de Profesores y Recursos de Cáceres. El eje central del trabajo han sido los diez primeros años (1986-1996) de funcionamiento del centro, desde su creación, su configuración interna y evolución, la red de formación pasando por el debate e implantación de la LOGSE, para poder comprender y explicar lo ocurrido en el proceso de planificación y desarrollo de dicha formación permanente y su incidencia en el desarrollo profesional de los profesores. Los objetivos de la investigación son: conocer el sistema adoptado por la Administración en materia de formación permanente, saber cuáles son los criterios, líneas, objetivos prioritarios a la hora de abordar la formación permanente del profesorado de Educación Primaria, analizar el papel desempeñado por el CPR, examinar las implicaciones del profesorado en las diferentes modalidades formativas y la incidencia de la LOGSE en su práctica docente, crear instrumentos para el análisis que ayuden a interpretar representativamente los hechos y los fenómenos que ocurren holísticamente, conocer las opiniones de los profesores y de las personas que han participado en los programas formativos, profundizar en los contenidos y en los procesos que han incidido en el itinerario formativo realizado, formular propuestas que tiendan a la adecuación y mejora de la formación del profesorado y contribuir a una línea de investigación centrada en la formación permanente del profesorado de Educación Primaria.

III Encuentro de la Red Extremeña de Escuelas Promotoras de Salud.

Cada experiencia recogida esta descrita por los profesores que la han llevado a cabo

Designing Gaussian basis sets to the theoretical study of the piezoelectric effect of perovskite (BaTiO3)

Gaussian basis sets (24s14p, 30s19p14d, and 33s21p14d for O (P-3), Ti (S-5), and Ba (S-1) atoms, respectively), are designed with the strategy of the Generator Coordinate Hartree-Fock method. The basis sets are then contracted to [6s4p], [10s5p4d], and [16s9p5d] to O, Ti, and Ba atoms, respectively, and used in calculations of total and orbital energies of (TiO+2)-Ti-1 and (BaO)-Ba-1 fragments for quality evaluation in molecular studies. For O atom, the [6s4p] basis set is enriched with d polarization function and used along with the [10s5p4d] and [16s9p5d] basis sets for the theoretical study of the piezoelectric effect of perovskite (BaTiO3). The results of this work evidence that the piezoelectric properties in BaTiO3 can be caused by electrostatic interactions. (C) 2003 Elsevier B.V. All rights reserved.

Evidence of thermostable amylolytic activity from Rhizopus microsporus var. rhizopodiformis using wheat bran and corncob as alternative carbon source

Rhizopus microsporus var. rhizopodiformis produced high levels of alpha-amylase and glucoamylase under solid state fermentation, with several agricultural residues, such as wheat bran, cassava flour, sugar cane bagasse, rice straw, corncob and crushed corncob as carbon sources. These materials were humidified with distilled water, tap water, or saline solutions-Segato Rizzatti (SR), Khanna or Vogel. The best substrate for amylase production was wheat bran with SR saline solution (1:2 v/v). Amylolytic activity was still improved (14.3%) with a mixture of wheat bran, corncob, starch and SR saline solution (1:1:0.3:4.6 w/w/w/v). The optimized culture conditions were initial pH 5, at 45 degrees C during 6 days and relative humidity around 76%. The crude extract exhibited temperature and pH optima around 65 degrees C and 4-5, respectively. Amylase activity was fully stable for 1 h at temperatures up to 75 degrees C, and at pH values between 2.5 and 7.5.