Portrait of Franz Catzenstein with his uncle Ernst Gottschalk.

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Portrait of Walter Godshaw, Charlie Sloan (Karl-Hermann Solomon), and Ida, Kaete Solomon's maid; Hannover, Germany.

From left to right: Walter Gottschalk, Ida, Charlie Sloan (Karl Hermann Solomon); Ida, Kaete Solomon's maid, nursed Charlie back to health after his release from Dachau

Portrait of Franz Catzenstein and his little sister Ellen. Portraits Children

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Portrait of Aenny Catzenstein nee Gottschalk holding her infant son Franz Portraits Family

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Portrait of Franz Matthiesen.

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Studio portrait of Franz Matthiesen Portraits Men

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Franz Matthiesen outdoors with his second wife Katherina Früh outside of Franz's Carton Hill home; London.

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Gottschalk family on vacation in front of Kurhaus Brunig; Norderney, Germany.

From left to right: man with camera: Karl Gottschalk; sitting on stairs: Fritz Gottschalk, unidentified woman, Therese Gottschalk nee Molling, Hans Ludwig, Kurt Gottschalk, unidentified woman (maid?) and Elizabeth Gottschalk

Franz Matthiesen and his mother Aenny Catzenstein nee Gottschalk; Oslo Court, London.

At the time Franz was ill with cancer but Aenny did not know.

Arthur Liebert, Albert Einstein, Franz Oppenheimer, Mrs. Kurt Goldstein, Fritz Medicus and Arthur Liebert's son walking outside the Grand Hotel Curhaus during the Davoser Hochschulkurse; Davos, Switzerland Portraits Groups

The Davoser Hochschulkurse took place for the first time in 1928. Mainly university teachers from Germany, France, Switzerland (perhaps elsewhere) offered lectures to students recovering from tuberculosis at the health resort in the Swiss mountains. The lecturers were accommodated at the Grand Hotel Curhaus, where the lectures also took place.

Lucien Levy-Bruehl, Albert Einstein, Franz Oppenheimer, Arthur Liebert and his son, Paul Tillich, unidentified woman and Mrs. Charles Blondel outside the Grand Hotel Curhaus during the Davoser Hochschulkurse; Davos, Switzerland Portraits Groups

The Davoser Hochschulkurse took place for the first time in 1928. Mainly university teachers from Germany, France, Switzerland (perhaps elsewhere) offered lectures to students recovering from tuberculosis at the health resort in the Swiss mountains. The lecturers were accommodated at the Grand Hotel Curhaus, where the lectures also took place.

Portrait of Walter Godshaw, Charlie Sloan (Karl-Hermann Solomon), and Ida, Kaete Solomon's maid; Hannover, Germany.

From left to right: Walter Gottschalk, Ida, Charlie Sloan (Karl Hermann Solomon); Ida, Kaete Solomon's maid, nursed Charlie back to health after his release from Dachau

Henriette Gottschalk nee Rothschild with her grandson Franz Catzenstein at the dining table in her garden.

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New genetic loci link adipose and insulin biology to body fat distribution

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10−8). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10−8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ~2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.