FKBPL: a marker of good prognosis in breast cancer

FK506-binding protein-like (FKBPL) has established roles as an anti-tumor protein, with a therapeutic peptide based on this protein, ALM201, shortly entering phase I/II clinical trials. Here, we evaluated FKBPL's prognostic ability in primary breast cancer tissue, represented on tissue microarrays (TMA) from 3277 women recruited into five independent retrospective studies, using immunohistochemistry (IHC). In a meta-analysis, FKBPL levels were a significant predictor of BCSS; low FKBPL levels indicated poorer breast cancer specific survival (BCSS) (hazard ratio (HR) = 1.30, 95% confidence interval (CI) 1.14-1.49, p < 0.001). The prognostic impact of FKBPL remained significant after adjusting for other known prognostic factors (HR = 1.25, 95% CI 1.07-1.45, p = 0.004). For the sub-groups of 2365 estrogen receptor (ER) positive patients and 1649 tamoxifen treated patients, FKBPL was significantly associated with BCSS (HR = 1.34, 95% CI 1.13-1.58, p < 0.001, and HR = 1.25, 95% CI 1.04-1.49, p = 0.02, respectively). A univariate analysis revealed that FKBPL was also a significant predictor of relapse free interval (RFI) within the ER positive patient group, but it was only borderline significant within the smaller tamoxifen treated patient group (HR = 1.32 95% CI 1.05-1.65, p = 0.02 and HR = 1.23 95% CI 0.99-1.54, p = 0.06, respectively). The data suggests a role for FKBPL as a prognostic factor for BCSS, with the potential to be routinely evaluated within the clinic.

Proceedings of the Grand Chapter of Royal Arch Masons of Canada at the annual convocation, 1872

Annual Convocation proceedings for the year 1872. The title varies slightly and convocation is held at different cities or towns in Canada. Fifteenth annual convocation.

Proceedings of the Grand Chapter of Royal Arch Masons of Canada at the annual convocation, 1873

Annual Convocation proceedings for the year 1873. Title varies slightly and convocation is held at different cities or towns in Canada. Sixteenth annual convocation.

Proceedings of the Grand Chapter of Royal Arch Masons of Canada at the annual convocation, 1874

Annual Convocation proceedings for the year 1874. The title varies slightly and convocation is held at different cities or towns in Canada. Seventeenth annual convocation.

Proceedings of the Grand Chapter of Royal Arch Masons of Canada at the annual convocation, 1875

Annual Convocation proceedings for the year 1875. The title varies slightly and convocation is held at different cities or towns in Canada. Eighteenth annual convocation.

Proceedings of the Grand Chapter of Royal Arch Masons of Canada at the annual convocation, 1876

Annual Convocation proceedings for the year 1876. The title varies slightly and convocation is held at different cities or towns in Canada. Nineteenth annual convocation.

Proceedings of the Grand Chapter of Royal Arch Masons of Canada at the annual convocation, 1877

Annual Convocation proceedings for the year 1877. The title varies slightly and convocation is held at different cities or towns in Canada. Twentieth annual convocation.

Proceedings of the Grand Chapter of Royal Arch Masons of Canada at the annual convocation, 1878

Annual Convocation proceedings for the year 1878. The title varies slightly and convocation is held at different cities or towns in Canada. Twenty-First annual convocation.

Proceedings of the Grand Chapter of Royal Arch Masons of Canada at the annual convocation, 1879

Annual Convocation proceedings for the year 1879. The title varies slightly and convocation is held at different cities or towns in Canada. Twenty-second annual convocation.

Proceedings of the Grand Chapter of Royal Arch Masons of Canada at the annual convocation, 1880

Annual Convocation proceedings for the year 1880. The title varies slightly and convocation is held at different cities or towns in Canada. Twenty-third annual convocation.

Proceedings of the Grand Chapter of Royal Arch Masons of Canada at the annual convocation, 1881

Annual Convocation proceedings for the year 1881. The title varies slightly and convocation is held at different cities or towns in Canada. Twenty-fourth annual convocation.