Analysis of the suitability of existing medical ontologies for building a scalable semantic interoperability solution supporting multi-site collaboration in oncology

Semantic interoperability is essential to facilitate efficient collaboration in heterogeneous multi-site healthcare environments. The deployment of a semantic interoperability solution has the potential to enable a wide range of informatics supported applications in clinical care and research both within as ingle healthcare organization and in a network of organizations. At the same time, building and deploying a semantic interoperability solution may require significant effort to carryout data transformation and to harmonize the semantics of the information in the different systems. Our approach to semantic interoperability leverages existing healthcare standards and ontologies, focusing first on specific clinical domains and key applications, and gradually expanding the solution when needed. An important objective of this work is to create a semantic link between clinical research and care environments to enable applications such as streamlining the execution of multi-centric clinical trials, including the identification of eligible patients for the trials. This paper presents an analysis of the suitability of several widely-used medical ontologies in the clinical domain: SNOMED-CT, LOINC, MedDRA, to capture the semantics of the clinical trial eligibility criteria, of the clinical trial data (e.g., Clinical Report Forms), and of the corresponding patient record data that would enable the automatic identification of eligible patients. Next to the coverage provided by the ontologies we evaluate and compare the sizes of the sets of relevant concepts and their relative frequency to estimate the cost of data transformation, of building the necessary semantic mappings, and of extending the solution to new domains. This analysis shows that our approach is both feasible and scalable.

(Table 8.4, Page 220-223) Chemical composition of different growth structures of manganese nodules, SONNE cruise SO78

In the nodule field of the Peru Basin, situated south of the zone of high bioproductivity, a relatively high flux of biogenic matter explains a distinct redox boundary at about 10 cm depth separating very soft oxic surface sediments from stiffer suboxic sediments. Maximum abundance (50 kg/m**2) of diagenetic nodules is found near the calcite compensation depth (CCD), currently at 4250 m. There, the accretion rate of nodules is much higher (100 mm/Ma) than on ridges (5 mm/Ma). Highest accretion rates are found at the bottom of large nodules that repeatedly sink to a level immediately above the redox boundary. There, distinct diagenetic growth conditions prevail and layers of dense laminated Mn oxide of very pure todorokite are formed. The layering of nodules is mainly the result of organisms moving nodules within the oxic surface sediment from diagenetic to hydrogenetic environments. The frequency of such movements is much higher than that of climatic changes. Two types of nodule burial occur in the Peru Basin. Large nodules are less easily moved by organisms and become buried. Consequently, buried nodules generally are larger than surface nodules. This type of burial predominates in basins. At ridges where smaller nodules prevail, burial is mainly controlled by statistical selection where some nodules are not moved up by organisms.

Symphony no. 1 in C minor : the bells of Zlonice /

Mode of access: Internet.

Fantin-Latour, sa vie et ses amitiés : lettres inédites et souvenirs personnels /

"Appendice: catalogue des tableaux à huile et pastels envoyés par Fantin-Latour aux Salons de Paris et de quelques autres importants dans son œuvre": p. [193]-210.

Records and maps of the old Sante Fe Trail.

Mode of access: Internet.

Oeuvres choisies de E. Scribe.

t. 1. La nuit d'un garde national ; Le nouveau pourceaugnac ; Le solliciteur ; Les deux précepteurs ; Une visite à Bedlam ; La somnambule ; L'ours et le pacha ; La secrétaire et le cuisinier ; Frontin mari-garc̦on ; L'intérieur d'une étude ; Michel et Christine ; Mémoires d'un Colonel de hussards ; La loge du portier ; L'intérieur d'un bureau ; Le menteur véridique ; La maîtresse au logis -- t. 2. Le coiffeur et le perruquier ; La mansarde des artistes ; La haine d'une femme ; La quarantaine ; Le plus beau jour de la vie ; Le charlatanisme ; Les premières amours ; Le confident ; La demoiselle à marier ; Simple histoire ; L'ambassadeur ; Le mariage de raison -- t. 3. L'héritière ; Le diplomate ; La marraine ; Un mariage d'inclination ; Louise, ou la réparation ; La seconde année ; Une faute ; La famille de Riquebourg -- t. 4. Le budget d'un jeune ménage ; Toujours ; Les malheurs d'un amant heureux ; La chanoinesse ; Ètre aimé ou mourir ; La pensionnaire mariée ; Clermont ou une femme d'artiste ; Le parrain ; Rodolphe ; Valérie -- t. 5. Le mariage d'argent ; Bertrand et Raton ; L'ambitieux ; La camaraderie ; La calomnie ; Le verre d'eau.

Romance literature pamphlets.

A collection of miscellaneous pamphlets.

Area wage survey.

Mode of access: Internet.

Occupational compensation survey--pay only.

Title from caption.