Morte de ciclista no Rio desencadeia debate sobre segurança pública

A morte do médico Jaime Gold, esfaqueado enquanto andava de bicicleta na orla da Lagoa Rodrigo de Freitas, terça-feira, 19 de maio, causou comoção e revolta nas redes sociais e desencadeou diversas discussões sobre pautas de segurança pública – como a redução da maioridade penal, o desarmamento e as estratégias de policiamento no estado do Rio de Janeiro. A FGV/DAPP coletou cerca de 36 mil menções ao assunto no Twitter, entre terça e quinta-feira, e construiu um grafo para ilustrar como os diferentes debates e posicionamentos estão articulados nas redes sociais.

Pulso do país

O Pulso do Brasil monitora, em tempo real, o que e onde as pessoas estão falando sobre os temas selecionados.

A gestão de processos no setor público: um estudo de caso dos processos de pensão por morte do Rioprevidência

Este estudo objetivou verificar as consequências do BPM nos processos de pensão por morte do Rioprevidência. Para isso, foram analisados três processos de trabalho executados pelo setor de atendimento do Rioprevidência, autarquia previdenciária do Estado do Rio de Janeiro, quais sejam: Habilitação à pensão por morte; Revisão de pensão e Auditoria de benefícios. O estudo se justifica face à escassez de trabalhos que apontem resultados de otimização de processos de trabalho em organizações do setor público, uma vez que a maior parte dos estudos existentes é voltada para a gestão de processos em empresas privadas e, aqueles que focalizam no setor público, normalmente apontam as diferenças com relação ao setor privado, ou seja, pouco se fala do resultado das transformações. Para alcançar esse objetivo, foi realizado um estudo de caso, com análise de conteúdo de dados e documentos, bem como modelagem dos processos selecionados, visando identificar as lacunas existentes antes do BPM, bem como de que maneira os processos foram impactados. Como contribuição prática, espera-se que o resultado sirva de incentivo aos demais órgãos públicos para implementação de uma gestão com foco em processos e aja como instrumento facilitador de uma melhor gestão pública.

A ciclovia da morte

De acordo com levantamento da FGV/DAPP, houve mais de 36 mil menções ao desabamento no Twi er, até o fim da tarde de ontem, com palavras como "vergonha", "incompetência" e "culpa" em destaque, além de muitas criticas ao prefeito Eduardo Paes.

Indução de morte celular em células de adenocarcinoma cervical humano (HeLa) pela lectina da esponja Cinachyrella apion (CaL)

Cancer is a term used to represent a set of more than 100 diseases, including malignant tumors from different locations. The malignancies are the second leading cause of death in the population, representing approximately 17% of deaths of known cause. Strategies that induce differentiation have had limited success in the treatment of established cancers. In this work, a lectin purified from the marine sponge Cinachyrella apion (CaL) was evaluated due to its hemolytic, cytotoxic and antiproliferative properties, besides the ability to induce cell death via apoptosis in tumor cells. The antiproliferative activity of CaL was tested against cell lines, with the highest inhibition of tumor growth for HeLa, reducing cell growth at a dose dependent manner, with a concentration of 10 μg/mL. The hemolytic activity and toxicity against peripheral blood cells were tested using the concentration of IC50 for both trials and twice the IC50 for analysis in flow cytometry, indicating that CaL is not toxic to these cells. To assess the mechanism of cell death caused by CaL in HeLa cells, we performed flow cytometry and western blotting. The results showed the lectin probably induces cell death by apoptosis activation by pro-apoptotic protein Bax, promoting mitochondrial membrane permeabilization, cell cycle arrest in S phase, with accumulation of cells of approximately 57% in this phase, and acting as both dependent and/or independent of caspases pathway. These results suggest that CaL has the potential to be used as drug treatment against cancer.

Avaliação do efeito do composto tipo heparina isolado do caranguejo Chaceon fenneri na hemostasia e na morte celular

Heparin is a pharmaceutical animal widely used in medicine due to its potent anticoagulant effect. Furthermore, it has the ability to inhibit the proliferation, invasion and adhesion of cancer cells to vascular endothelium. However, its clinical applicability can be compromised by side effects such as bleeding. Thus, the search for natural compounds with low bleeding risk and possible therapeutic applicability has been targeted by several research groups. From this perspective, this study aims to evaluate the hemorrhagic and anticoagulant activities and citotoxic effect for different tumor cell lines (HeLa, B16-F10, HepG2, HS-5,) and fibroblast cells (3T3) of the Heparin-like from the crab Chaceon fenneri (HEP-like). The HEP-like was purified after proteolysis, ion-exchange chromatography, fractionation with acetone and characterized by electrophoresis (agarose gel) and enzymatic degradation. Hep-like showed eletroforetic behavior similar to mammalian heparin, and high trisulfated /Nacetylated disaccharides ratio. In addition, HEP-like presented low in vitro anticoagulant activity using aPTT and a minor hemorrhagic effect when compared to mammalian heparin. Furthermore, the HEP-like showed significant cytotoxic effect (p<0.001) on HeLa, HepG2 and B16-F10 tumor cells with IC50 values of 1000 ug/mL, after incubation for 72 hours. To assess the influence of heparin-like on the cell cycle in HeLa cells, analysis was performed by flow cytometry. The results of this analysis showed that HEP-like influence on the cell cycle increasing S phase and decreasing phase G2. Thus, these properties of HEP-like make these compounds potential therapeutic agents

Morte como desafio afetivo para o profissional da saúde: ansiedade e sentimentos de quem lida com o paciente terminal com câncer

It is a Cross-sectional and multi-disciplinary study whose population selection was made by department of human resources (composed by a Manager, an Oncologist and a Psychologist) from the hospital where this research was realized. They also collaborated with important information about the work of that professionals in the hospital. We also counted on a Statistic who made study design calculating the sample and analyzing data. This research issued Evaluating health professionals anxiety levels who care for cancer terminally ill and their feelings about that work as well as identifying the factors which have influence on it. 100 health professionals from the Hospital which is a reference on cancer caring in Brazil situated in the city of Natal, state of Rio Grande do Norte, participated of this research. There was a sample loss of 21%. Data were collected through a questionnaire and State-Trait Anxiety Inventory (STAI). Results showed that 15% of the professionals have low State Anxiety levels, 70% Medium State Anxiety levels and 15% high State anxiety levels. The Number of Patients and Working in another Institution have interfered in the anxiety levels. Doctors and Nursing Assistants and Technicians have got the highest high State Anxiety percentage (25%). 73% of them declare to feel some sort of different behavior and/or feelings in caring for terminally ill. The most remarkable professionals feelings were Suffering and Sadness, and Terminally ill Children was the most difficult age group to care for. We conclude that work overload and having more than one job can interfere in professional stress levels and anxiety. Dealing with terminally ill, specially children one, can cause on the professionals psychological suffering. It s recommended the development of supporting and training strategies to reduce and/or to prevent Stress and Anxiety high levels