Tea tree oil (5%) body wash versus standard care (Johnson's Baby Softwash) to prevent colonization with methicillin-resistant Staphylococcus aureus in critically ill adults::a randomized controlled trial

OBJECTIVES: To determine whether the daily use of 5% tea tree oil (TTO) body wash (Novabac 5% Skin Wash) compared with standard care [Johnson's Baby Softwash (JBS)] had a lower incidence of methicillin-resistant Staphylococcus aureus (MRSA) colonization.

PATIENTS: The study setting was two intensive care units (ICUs; mixed medical, surgical and trauma) in Northern Ireland between October 2007 and July 2009. The study population comprised 391 patients who were randomized to JBS or TTO body wash.

METHODS: This was a Phase 2/3, prospective, open-label, randomized, controlled trial. Trial registration: ISRCTN65190967. The primary outcome was new MRSA colonization during ICU stay. Secondary outcomes included the incidence of MRSA bacteraemia and maximum increase in sequential organ failure assessment score.

RESULTS: A total of 445 patients were randomized to the study. After randomization, 54 patients were withdrawn; 30 because of a positive MRSA screen at study entry, 11 due to lack of consent, 11 were inappropriately randomized and 2 had adverse reactions. Thirty-nine (10%) patients developed new MRSA colonization (JBS n?=?22, 11.2%; TTO body wash n?=?17, 8.7%). The difference in percentage colonized (2.5%, 95% CI -?8.95 to 3.94; P?=?0.50) was not significant. The mean maximum increase in sequential organ failure assessment score was not significant (JBS 1.44, SD 1.92; TTO body wash 1.28, SD 1.79; P?=?0.85) and no study patients developed MRSA bacteraemia.

CONCLUSIONS: Compared with JBS, TTO body wash cannot be recommended as an effective means of reducing MRSA colonization.

Johnson Creek S108

The South Carolina Department of Natural Resources provides maps to recreational and state shellfish grounds, available to the public for recreational harvesting or to commercial harvest. This map shows the location of Johnson Creek S108 Recreational Shellfish Ground in Beaufort County.

Prime Minister and President: Harold Macmillan’s accounts of the Cuban missile crisis

This chapter analyses the successive ways in which Macmillan re-wrote his experiences of the Cuban missile crisis and in the process sought to re-configure the memory of the event in Britain.

Recueil tres-exact et curieux de tout ce qui s'est fait & passé de singulier & memorable en l'assemblée generale des Estats tenus à Paris en l'année 1614 . & particulierement en chacune seance du tiers ordre. Avec le cahier dudit ordre, & autres pieces concernans le mesme sujet. Par Me Florimond Rapine, seigneur de Foucherainne & Lathenon, conseiller & premier advocat du Roy au bailliage & siege presidial de St Pierre le Moustier, & l'un des deputez pour le tiers Estat dudit bailliage. Dedié a monseigneur le premier president, garde des sceaux de France...

[Acte. 1651]

President Gibson

Dr. Gibson wearing his academic gown.

President Chosen

A special meeting of several Founders Committee members took place at Arthur A. Schmon's House in Niagara on the Lake immediately after the announcement in September of 1963 that Dr. James Alexander Gibson would be the first president of Brock University as of January 1964. Pictured here from left to right are: Dr. Gibson, Dr. Schmon, Dr. Deeks, and Mr. Willmot.