The challenges for molecular nutrition research 1: linking genotype to healthy nutrition

Nutrition science finds itself at a major crossroad. On the one hand we can continue the current path, which has resulted in some substantial advances, but also many conflicting messages which impair the trust of the general population, especially those who are motivated to improve their health through diet. The other road is uncharted and is being built over the many exciting new developments in life sciences. This new era of nutrition recognizes the complex relation between the health of the individual, its genome, and the life-long dietary exposure, and has lead to the realisation that nutrition is essentially a gene - environment interaction science. This review on the relation between genotype, diet and health is the first of a series dealing with the major challenges in molecular nutrition, analyzing the foundations of nutrition research. With the unravelling of the human genome and the linking of its variability to a multitude of phenotypes from " healthy'' to an enormously complex range of predispositions, the dietary modulation of these propensities has become an area of active research. Classical genetic approaches applied so far in medical genetics have steered away from incorporating dietary effects in their models and paradoxically, most genetic studies analyzing diet-associated phenotypes and diseases simply ignore diet. Yet, a modest but increasing number of studies are accounting for diet as a modulator of genetic associations. These range from observational cohorts to intervention studies with prospectively selected genotypes. New statistical and bioinformatics approaches are becoming available to aid in design and evaluation of these studies. This review discusses the various approaches used and provides concrete recommendations for future research.

Analysis of physiological data from the International Clonal Trial (CFC)

A range of physiological parameters (canopy light transmission, canopy shape, leaf size, flowering and flushing intensity) were measured from the International Clone Trial, typically over the course of two years. Data were collected from six locations, these being: Brazil, Ecuador, Trinidad, Venezuela, Côte d’Ivoire and Ghana. Canopy shape varied significantly between clones, although it showed little variation between locations. Genotypic variation in leaf size was differentially affected by the growth location; such differences appeared to underlie a genotype by environment interaction in relation to canopy light transmission. Flushing data were recorded at monthly intervals over the course of a year. Within each location, a significant interaction was observed between genotype and time of year, suggesting that some genotypes respond to a greater extent than others to environmental stimuli. A similar interaction was observed for flowering data, where significant correlations were found between flowering intensity and temperature in Brazil and flowering intensity and rainfall in Côte d’Ivoire. The results demonstrate the need for local evaluation of cocoa clones and also suggest that the management practices for particular planting material may need to be fine-tuned to the location in which they are cultivated.

The role of the international cocoa germplasm database and the international cocoa quarantine centre in information management and distribution of cocoa genetic resources

A range of physiological parameters (canopy light transmission, canopy shape, leaf size, flowering and flushing intensity) were measured from the International Clone Trial, typically over the course of two years. Data were collected from six locations, these being: Brazil, Ecuador, Trinidad, Venezuela, Côte d’Ivoire and Ghana. Canopy shape varied significantly between clones, although it showed little variation between locations. Genotypic variation in leaf size was differentially affected by the growth location; such differences appeared to underlie a genotype by environment interaction in relation to canopy light transmission. Flushing data were recorded at monthly intervals over the course of a year. Within each location, a significant interaction was observed between genotype and time of year, suggesting that some genotypes respond to a greater extent than others to environmental stimuli. A similar interaction was observed for flowering data, where significant correlations were found between flowering intensity and temperature in Brazil and flowering intensity and rainfall in Côte d’Ivoire. The results demonstrate the need for local evaluation of cocoa clones and also suggest that the management practices for particular planting material may need to be fine-tuned to the location in which they are cultivated.

A climate of control: flooding, displacement and planned resettlement in the Lower Zambezi River valley, Mozambique

In recent years, the potential role of planned, internal resettlement as a climate change adaptation measure has been highlighted by national governments and the international policy community. However, in many developing countries, resettlement is a deeply political process that often results in an unequal distribution of costs and benefits amongst relocated persons. This paper examines these tensions in Mozambique, drawing on a case study of flood-affected communities in the Lower Zambezi River valley. It takes a political ecology approach – focusing on discourses of human-environment interaction, as well as the power relationships that are supported by such discourses – to show how a dominant narrative of climate change-induced hazards for small-scale farmers is contributing to their involuntary resettlement to higher-altitude, less fertile areas of land. These forced relocations are buttressed by a series of wider economic and political interests in the Lower Zambezi River region, such dam construction for hydroelectric power generation and the extension of control over rural populations, from which resettled people derive little direct benefit. Rather than engaging with these challenging issues, most international donors present in the country accept the ‘inevitability’ of extreme weather impacts and view resettlement as an unfortunate and, in some cases, necessary step to increase people’s ‘resilience’, thus rationalising the top-down imposition of unpopular social policies. The findings add weight to the argument that a depoliticised interpretation of climate change can deflect attention away from underlying drivers of vulnerability and poverty, as well as obscure the interests of governments that are intent on reordering poor and vulnerable populations.

The dimensions of expatriate adjustment

A narrow and partial theoretical base has limited current concepts of expatriate adjustment and the research based upon them. This conceptual article explores one of the less theorized aspects of expatriate adjustment: the fact that it has multiple dimensions. We conceive of adjustment as a person-environment relationship that takes place in the three dimensions of cognitions, feelings, and behaviors. Combining these elements takes us one step closer to a comprehensive and more realistic understanding of the nature of expatriate adjustment. We include suggestions for future research that follow from our reconceptualization

Examining the relationships between Holocene climate change, hydrology, and human society in Ireland

This thesis explores human-environment interactions during the Mid-Late Holocene in raised bogs in central Ireland. The raised bogs of central Ireland are widely-recognised for their considerable palaeoenvironmental and archaeological resources: research over the past few decades has established the potential for such sites to preserve sensitive records of Holocene climatic variability expressed as changes in bog surface wetness (BSW); meanwhile archaeological investigations over the past century have uncovered hundreds of peatland archaeological features dating from the Neolithic through to the Post-Medieval period including wooden trackways, platforms, and deposits of high-status metalwork. Previous studies have attempted to explore the relationship between records of past environmental change and the occurrence of peatland archaeological sites reaching varying conclusions. More recently, environmentally-deterministic models of human-environment interaction in Irish raised bogs at the regional scale have been explicitly tested leading to the conclusion that there is no relationship between BSW and past human activity. These relationships are examined in more detail on a site-by-site basis in this thesis. To that end, testate amoebae-derived BSW records from nine milled former raised bogs in central Ireland were produced from sites with known and dated archaeological records. Relationships between BSW records and environmental conditions within the study area were explored through both the development of a new central Ireland testate amoebae transfer function and through comparisons between recent BSW records and instrumental weather data. Compilation of BSW records from the nine fossil study sites show evidence both for climate forcing, particularly during 3200-2400 cal BP, as well as considerable inter-site variability. Considerable inter-site variability was also evident in the archaeological records of the same sites. Whilst comparisons between BSW and archaeological records do not show a consistent linear relationship, examination of records on a site-by-site basis were shown to reveal interpretatively important contingent relationships. It is concluded therefore, that future research on human-environment interactions should focus on individual sites and should utilise theoretical approaches from the humanities in order to avoid the twin pitfalls of masking important local patterns of change, and of environmental determinism.

Interpreting Fanger's comfort equation within the adaptive paradigm

This paper reviews the evolution of Fanger's heat balance equation in regard of adaptive opportunities. Heat balance and adaptive response are integrated into one model as two fundamental aspects of human-environment interaction that define thermal comfort perception, rather than being seen as two concepts of alternative comfort paradigms. The paper suggests to extent Fanger's model with a heat storage term in order to account for comfort perception under transient thermal conditions, and to review Fanger's modelling assumptions in order to allow for a greater variety of adaptive response options. In the presented model heat exchange is modulated through adaptation of physiological, environmental and behavioural parameters in the human-environment system defined through Fanger's heat exchange equations. A computational prototype is implemented to determine 'comfortable' values and ranges of the six comfort dimensions alternatively to Fanger's comfort indices. Thereby values of for example 'comfortable' clothing and metabolic rate are results rather than necessary input parameters, which are difficult to determine. This approach allows generating design advice for physical, organisational and social environments based on heat balance calculation in the six-dimensional opportunity space defined through Fanger's comfort equation. A starting point for the development of a dynamic adaptive comfort model is set.

Affect : initiating heuristic life

This paper re-examines the relationship between affect and effect, discussing them as research values that have emerged from the life sciences, the arts and philosophy and, more importantly, considering them as systems of relations underpinning experiential orientation by which to initiate change and hold the world in place. The notion of æffect may be defined as the continuous measure performed upon the systems of affect/effect and reapplied to events and things. Æffect is a coordinated system of cognition where concurrent measures impact on each other. In doing so, they specify perception and action on multiple registers and scales of events. It is important to recognise that the functioning of affective and effective systems in the body allows, and even requires, paradoxical logics to coexist and be deployed as processes that shape the organism-person-environment. Discussion of selected works from Arakawa and Gins will supply examples of tactics that combine built environments with discursive constraints to guide embodied attention. The practice of embodied cognition dilates the thresholds separating the organism from person and the person from environment, and moves towards an atmospheric intricateness (Arakawa and Gins 2003a:25) that may become the blocs of a new materialism for heuristic life.

Employees' perceptions of fit and misfit

What makes some people feel that they fit in at work whilst others feel they misfit? This brief paper outlines a study which is currently in progress to explore individuals’ perceptions of fit and misfit at work. In the person-organisation and person-environment fit literature, fit and misfit tend to be shown as two ends of a spectrum, with an underlying assumption being that the two states are polar opposites. Whilst this seems intuitively logical, there has been no empirical test of this core assumption in the literature. This paper outlines a qualitative study, using causal mapping, to identify the factors affecting employees’ fit and misfit perceptions at work. It is anticipated that by the time of the BAM conference, the data analysis will be complete and full findings will be available.

The (almost) ubiquitous ASA framework

Ben Schneider’s ASA framework and the associated idea of homogeneity is a theoretical cornerstone on which most organisational person-environment (PE) fit studies are built. However, whilst it is commonly used to justify studies and to explain empirical findings, very few PE fit studies have moved the underlying ASA framework forward. More than 20 years on, the theory remains intact and has barely evolved. This paper begins with a short citation review that illustrates how the ASA framework is used in empirical studies. Following this, the body of the paper explores the reasons why the empirical studies that use the ASA framework as their theoretical underpinning are ineffective in revising Schneider’s ideas. The paper concludes with a discussion of the ASA framework’s rhetorical role and its inappropriateness as a theoretical justification of empirical PE fit studies.

The ASA framework as rhetoric

Ben Schneider’s ASA framework and the associated idea of homogeneity is a theoretical cornerstone on which most organisational person-environment (PE) fit studies are built. However, whilst it is commonly used to justify studies and to explain empirical findings, very few PE fit studies have moved the underlying ASA framework forward. More than 20 years on, the theory remains intact and has barely evolved. This paper contains a citation review that illustrates how the ASA framework is used in empirical studies. Following this, the body of the paper explores the reasons why the empirical studies that use the ASA framework as their theoretical underpinning are ineffective in revising Schneider’s ideas. The paper concludes with a discussion of the ASA framework’s rhetorical role and its inappropriateness as a theoretical justification of empirical PE fit studies.

The "strugglers" in selected computer based mathematics classrooms

In this paper, the experiences of lower achieving mathematics students in two secondary mathematics classrooms in which computers were regularly used are described. A year 8 and a year 9 mathematics class from one secondary school participated in the ethnographic study. The results show that in these two classrooms the learning relationships and power relationships did not, in general, support the learning and engagement of lower achievers in mathematics. Research into computer based teaching methods that engage low achieving students in computer based mathematics is needed.

Fuzzy simulation of pedestrian walking path considering local environmental stimuli

Pedestrian steering activity is a perception-based decision making process that involves interaction with the surrounding environment and insight into environmental stimuli. There are many stimuli within the environment that influence pedestrian wayfinding behaviour during walking activities. However, compelling factors such as individual physical and psychological characteristics and trip intention cause the behaviour become a very fuzzy concept. In this paper pedestrian steering behaviour is modelled using a fuzzy logic approach. The objective of this research is to simulate pedestrian walking paths in indoor public environments during normal and non-panic situations. The proposed algorithm introduces a fuzzy logic framework to predict the impact of perceived attractive and repulsive stimuli, within the pedestrian's field of view, on movement direction. Environmental stimuli are quantified using the social force method. The algorithm is implemented in a simulated area of an office corridor consist of a printer and exit door. Stochastic simulation using the proposed fuzzy algorithm generated realistic walking trajectories, contour map of dynamic change of environmental effects in each step of movement and high flow areas in the corridor.

The impact of self-efficacy and perceived system efficacy on effectiveness of virtual training systems

This study developed and tested a research model which examined the impact of user perceptions of self-efficacy (SE) and virtual environment (VE) efficacy on the effectiveness of VE training systems. The model distinguishes between the perceptions of one’s own capability to perform trained tasks effectively and the perceptions of system performance, regarding the established parameters from literature. Specifically, the model posits that user perceptions will have positive effects on task performance and memory. Seventy-six adults participated in a VE in a controlled experiment, designed to empirically test the model. Each participant performed a series of object assembly tasks. The task involved selecting, rotating, releasing, inserting and manipulating 3D objects. Initially, the results of factor analysis demonstrated dimensionality of two user perception measures and produced a set of empirical validated factors underlining the VE efficacy. The results of regression analysis revealed that SE had a significant positive effect on perceived VE efficacy. No significant effects were found of perceptions on performance and memory. Furthermore, the study provided insights into the relationships between the perception measures and performance measures for assessing the efficacy of VE training systems. The study also addressed how well users learn, perform, adapt to and perceive the VE training, which provides valuable insight into the system efficacy.
Research and practical implications are presented at the end of the paper.