981 resultados para Neu Oncogene


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Boberach: Der Entwurf der Siebzehner wird abgelehnt. Deutschland soll keinen Erbkaiser, sondern eine Regentschaft als Spitze haben. Ein kleinerer Fürst als Diktator ist der preußischen Vorherrschaft vorzuziehen. Es genügt eine Reform des Deutschen Bundes mit einem Parlament als Gegengewicht gegen die Fürsten. Das Präsidium soll alle drei Jahre zwischen Österreich, Preußen und Bayern abwechseln, ein Bundesgericht in Nürnberg errichtet werden

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Boberach: Knappen Darstellungen der Ereignisse in Baden, der Pfalz und Dresden 1849 und der Wiener Oktoberrevolution 1848 folgen Beiträge über Max Dortu, Gustav Schlöffel, Blum, August Bernigau, Messenhäuser [sic!], Lamartine, Bem, Graf Batthyani, Struve, Greiner, P. Fries, Reichard, Hepp, Hanitz, Nikolaus Schmitt, Cullmann [sic!], Goldmark, d'Ester, Franz Umbscheiden, Blenker, Raquillet [sic!], Sznayder [sic!], Zitz, Eisenstuck, Crzeriak, Fr. Ludwig Krahn, Dr. Sander, Jodokus Temme, Schulze-Delitzsch, Carl Vogt; eingefügt sind Briefe und Aufzeichnungen über die Prozesse in Rastatt, die Prager Unruhen im Juni 1848, die Kämpfe in Ungarn und die Lage der Emigranten, ferner Gedichte, u.a. von Herwegh

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Welsch (Projektbearbeiter): Deutschkatholische Predigt des ehemaligen römisch-katholischen Kaplans von Wien-Erdberg Hermann Pauli anläßlich des Festes Mariä Himmelfahrt (15. August 1848)

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Franz Oppenheimer

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Moses Gaster

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Michael Flürscheim

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Michael Flürscheim

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Genetic analysis, both karyotyping and comparative genomic hybridization, of prostate cancer cell lines and specimens have revealed multiple areas of concordant increases in DNA content. An increase of DNA in specific regions of the genome in cancer is often associated with the amplification of oncogenes. Based on these observations we have hypothesized that oncogenes are involved in the initiation or progression of prostate cancer. An expression cloning approach was utilized to identify candidate oncogenes in prostate cancer. ^ A full-length, unidirectional cDNA expression library was constructed from DU145 prostate cancer cells. The cDNA library was screened using CP12, a rat prostate epithelial cell line. In soft agarose assays, CP12 (parental or vector transfected) do not form colonies. However, upon the introduction of a number of known oncogenes CP12 becomes anchorage independent in soft agarose. Based on this in-vitro phenotypic shift, a DU145 cDNA library was stably transfected into CP12, and selected for anchorage independence. Two hundred fifty nine anchorage independent clones were isolated. Some colonies contained more than one insert, bringing the candidate oncogene pool to approximately 400. Seven inserts were sequenced at random. Using the sequences obtained, GenBank was screened, and matches were found with p53, PARG1, a mitochondrial ATPase, RNF6, and three unknown genes that mapped to Unigene clusters. As the pool of cDNA inserts appeared promising, overexpressed genes were further selected. From 259 clones, 17 clones were overexpressed more than 6-fold in DU145 compared to Normal Prostate. From the 17 clones, 12 cDNA inserts were strongly expressed in DU145 and were isolated for sequencing. ^ Two of the sequences, 1G6 and 3E9, were identical. Expression of 1G6/2G9/3E9 was tested by RT-PCR. 1G6/2G9/3E9 was not expressed in normal prostate, but was expressed in all prostate cancer cell lines tested as well as six prostate cancer samples. When retransfected into CP12, 1G6/2G9/3E9 induced the formation of foci and anchorage independent colonies. Thus, functional and expression data suggest that 1G6/2G9/3E9 may be a prostate cancer oncogene. ^