Ms. Barth. 126 - Doctrinale cum commento

Vorbesitzer: Brun zu Brunfels; Jungo Frosch; Brune-Kütze-Legat; Bartholomaeusstift Frankfurt am Main

Ms. Barth. 150 - Mainzer Stiftsbrevier

Vorbesitzer: Johann Brune (genannt Henne) zum Schmidtskiele; Jungo Frosch; Johann Heller; Jakob Heller; Bartholomaeusstift Frankfurt am Main

Ms. Barth. 157 (Ausst. 25) - Liber testimoniorum veteris testamenti ex opusculis S. Gregorii excerptus

Vorbesitzer: Brune-Kütze-Legat; Bartholomaeusstift Frankfurt am Main

Ms. Barth. 167 - Theologische Sammelhandschrift

Vorbesitzer: Brune-Kütze-Legat; Bartholomaeusstift Frankfurt am Main

Ms. Barth. 168 - Theologische Sammelhandschrift

Vorbesitzer: Brune-Kütze-Legat; Bartholomaeusstift Frankfurt am Main

Ms. Barth. 173 - Florilegia patristica

Vorbesitzer: Brune-Kütze-Legat; Bartholomaeusstift Frankfurt am Main

Ms. Barth. 115 (Ausst. 27) - Legenda aurea

Vorbesitzer: Johannes de Dusburg; Brune-Kütze-Legat; Bartholomaeusstift Frankfurt am Main

Activation of Ca2+ signaling in neutrophils by the mast cell-released immunophilin FKBP12.

The immunophilins of the FK506-binding protein (FKBP) family are intracellular proteins that bind the immunosuppresants FK506 and rapamycin. In this study we show that HMC-1 mast cells sensitized with IgE release FKBP12 upon stimulation with anti-IgE. The release is rapid and not affected by actinomycin D or cycloheximide, suggesting that it is due to exocytosis from a storage compartment. FKBP12 from HMC-1 mast cells exhibits biological activity. When applied extracellularly to human neutrophils, it induces transient changes in the intracellular Ca2+ concentration ([Ca2+]i) due to Ca2+ release from intracellular stores. Inhibition of [Ca2+]i changes by ruthenium red and ryanodine indicates that ryanodine receptor/Ca2+ release channels are involved in FKBP12-induced Ca2+ signaling. Neutrophil activation by mast cell-derived FKBP12 is prevented by complexing FKBP12 with FK506 or rapamycin. These results demonstrate that extracellular FKBP12 functions as a cytokine in cell-to-cell communication. They further suggest a pathophysiological role for FKBP12 as a mediator in immediate or type I hypersensitivity and may have implications for novel therapeutic strategies in the treatment of allergic disorders with FK506 and rapamycin.

Dinoflagellate cysts in surface sediment samples of METEOR cruises M20/2, M23/1, M34/1, M34/2, M34/3 and M34/4

To enhance the limited information available about the palaeo-ecological significance of calcareous dinoflagellates, we have studied their lateral distribution in surface sediments of the equatorial and south Atlantic between 13°N and 36°S. Calcareous dinoflagellate cysts appear to be widely distributed throughout the studied area. In the surface sediments, concentrations (cyst per gram dry sediment) of the vegetative stage Thoracosphaera heimii are generally higher than that of the (presumably) calcareous resting cysts. Distribution patterns in surface sediments of Orthopithonella granifera (Fütterer) Keupp and Versteegh, Rhabdothorax spp. Kamptner., Sphaerodinella albatrosiana (Kamptner) Keupp and Versteegh S. albatrosiana praratabulated, Sphaerodinella tuberosa var. 1 (Kamptner) Keupp and Versteegh and S. tuberosa var. 2 and the ratios between these species have been compared with temperature, salinity, density and stratification gradients in the upper water column. Rhabdothorax spp. is characteristically present in sediments of more temperate regions characterized by high seasonality. Dinoflagellates producing these cysts are able to tolerate high nutrient concentrations, and mixing of the water column. S. albatrosiana is abundant in regions characterized by high sea surface temperatures and oligotrophic surface water conditions. In contrast, the distribution of S. tuberosa var. 2 is negatively related to temperature. The other cyst species did not show a characteristic pattern in relation to the studied environmental gradients. The ratio of Sphaerodinella tuberosa var. 2 to Orthopithonella granifera can be used for reconstructing the presence of stratification in the upper 50 m of the water column, whereas the ratios of S. tuberosa var. 2 to Sphaerodinella albatrosiana and of O. granifera to Rhabdothorax spp. might be used for palaeotemperature reconstructions. Calcareous dinoflagellate cysts are abundant in oligotrophic areas and may be useful for the reconstruction of palaeoenvironmental conditions.

Manuel d'anatomie chirurgicale, général et topographique /

Mode of access: Internet.

Rates of sediment production in the western Gulf States /

One folded map in pocket.

Éléments de physiologie de l'homme et des principaux vertébrés... /

Mode of access: Internet.

Elementos de fisiología del hombre y de los principales vertebrados /

Mode of access: Internet.