Convergence of products from Povarov and von Miller reactions: approaches to helquinoline

Yttrium triflate or triflic acid catalysed Povarov reaction of methyl anthranilate with ethyl vinyl ether, both as aldehyde surrogate and as alkene, gave the desired 2-methyl-4-ethoxytetrahydroquinoline diastereoisomers as the major products along with four component coupling von Miller adducts. A proton NMR-study, using yttrium triflate as catalyst, revealed that the cis-diastereoisomers were the initial major products in both the Povarov and von Miller reactions but that these isomerised to the trans-diastereoisomers under the reaction conditions. Two distinct pathways for forming von Miller adducts were uncovered with the initial Povarov products being converted to von Miller adducts under the reaction conditions. Replacement of the 4-ethoxy with a 4-methoxy group under acidic conditions gave predominantly the trans-diastereoisomer, which was subsequently converted to a cis/trans mixture of the tetrahydroquinoline antibiotic helquinoline. It was also possible to convert the von Miller products to Povarov products under acidic conditions

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

To assess factors influencing the success of whole-genome sequencing for mainstream clinical diagnosis, we sequenced 217 individuals from 156 independent cases or families across a broad spectrum of disorders in whom previous screening had identified no pathogenic variants. We quantified the number of candidate variants identified using different strategies for variant calling, filtering, annotation and prioritization. We found that jointly calling variants across samples, filtering against both local and external databases, deploying multiple annotation tools and using familial transmission above biological plausibility contributed to accuracy. Overall, we identified disease-causing variants in 21% of cases, with the proportion increasing to 34% (23/68) for mendelian disorders and 57% (8/14) in family trios. We also discovered 32 potentially clinically actionable variants in 18 genes unrelated to the referral disorder, although only 4 were ultimately considered reportable. Our results demonstrate the value of genome sequencing for routine clinical diagnosis but also highlight many outstanding challenges.

Plat survey of Edward Burch's land

This document is a plat survey of Edward Burch, O. H. Spencer, Alex Powe, and Ann Spencer land.

Ao oriente do oriente transformações do orientalismo em poesia portuguesa do início do século XX . Camilo Pessanha, Alberto Osório de Castro e Álvaro de Campos

Tese de doutoramento, Estudos de Literatura e de Cultura (Estudos Comparatistas), Universidade de Lisboa, Faculdade de Letras, 2014

Julius Caesar, August 8, 1939

Concert program for Julius Caesar, August 8, 1939

Departmental Select Committees

The idea of departmental select committees in the House of Commons was floated as long ago as the Haldane Report in 1918 and periodically mooted by figures from both left and right as varied as Amery and Laski in the inter‐war years. It was raised again during the wartime investigations of the Machinery of Government committee, only to be shot down by the then Cabinet Secretary, Sir Edward Bridges, on the grounds that it would constrain the frankness with which the Civil Service could advise ministers. Departmental select committees were not to be introduced until 1979. Ten years ago the Institute of Contemporary British History organised a symposium to review their progress. On 31 January 1996 in committee room 10 at the House of Commons the ICBH, in conjunction with the Hansard Society, held another seminar to re‐examine the development of the departmental select committee system, its successes and failings. It was chaired by George Cunningham (Labour MP 1970–82, SDP MP 1982–83). The principal participants were Sir Peter Kemp (Deputy Secretary, Treasury 1983–88, Next Steps Project Manager, Cabinet Office, 1988–92), Douglas Millar (Clerk of Select Committees, House of Commons since 1994), Dr Ann Robinson (author of Parliament and Public Spending, head of the policy unit at the Institute of Directors [IOD], 1989–95 and Director‐General of the National Association of Pension Funds Ltd since 1995), Robert Sheldon (Labour MP since 1964, Financial Secretary to the Treasury 1974–75, member of the Public Accounts Committee [PAC] 1965–70 and 1975–79 and chairman since 1983, member, Public Expenditure Committee 1972–74, and member of the Treasury and Civil Service Committee [TCSC] 1979–81) and Sandy Walkington (head of corporate affairs at BT [British Telecom] plc), with further contributions from Peter Riddell (assistant editor: politics, The Times, since 1993), Chloe Miller, Sean McDougall, Tim King and Chris Stevens.

Reassessing the impact of yesterday's men

This special seminar to explore the controversy surrounding the Yesterday's Men programme of 1971, and its subsequent significance in the history of British political documentaries, was held at the Institute of Historical Research, London, on 26 January 1994. The seminar opened with a re‐screening of the programme, which featured interviews with Harold Wilson, the then leader of the opposition to Edward Heath's new Conservative government, front bench opposition spokesmen including Roy Jenkins, Tony Crosland and Denis Healey, and the political correspondent Peter Jenkins. The discussion was introduced by Dr Jean Seaton and chaired by Professor Peter Hennessy. The principal participants were Joe Haines (Chief Press Secretary to Harold Wilson 1969–76), Brian Wenham (editor, Panorama 1969–71, Head of BBC Current Affairs Group 1971–78) and John Grist (Head of BBC Current Affairs Group 1967–71, Controller, BBC English Regions 1972–77), with further contributions from Philip Whitehead, Professor Ben Pimlott, Peter Rose, David Benn, Professor Colin Seymour‐Ure, Joanna Kayford, Rosaleen Hughes, Hugh Purcell, Murray Weston and Chloe Miller.

Edward Tylor e a extraordinária evolução religiosa da humanidade

Cadernos de Campo. Revista dos alunos de pós-graduação em Antropologia Social da USP, ano 19, Jan.-Dez. 2010, pág. 297-308.

Escala de madurez gonadal de anchoveta blanca Anchoa nasus (Kner y Steindachner, 1867)

Se presenta la escala de madurez gonadal de anchoveta blanca Anchoa nasus. El proceso de maduración y desove se ha clasificado en seis estadios tanto para hembras como para machos. Se examinaron cortes histológicos de 442 individuos de anchoveta blanca colectados a bordo del BIC J. Olaya, durante las operaciones de verano del 2008 y 2009 y del invierno primavera del 2012 y 2013. Se describe las características visuales externas y las microscópicas que definen cada uno de los estadios.

Escala de madurez gonadal del lenguado Paralichthys adspersus (Steindachner, 1867)

Se presenta la escala de madurez gonadal del lenguado Paralichthys adspersus, elaborada en base al análisis y procesamiento histológico de 96 ovarios y 66 testículos de ejemplares capturados en la costa central del Perú y mantenidos en cautiverio. Los ovarios fueron clasificados micro y macroscópicamente, teniendo en cuenta el desarrollo de gametos y gonadas en: virginal, reposo, en maduración, maduro, desovante y recuperación; y a los testículos en virginal, reposo, en maduración, maduro, expulsante y post expulsante. La comparación de las características macro y microscópicas de las gónadas de peces en cautiverio no mostraron ninguna diferencia con respecto a las gónadas de los peces en su ambiente natural.

La Rue (1867)

Périodicité : Hebdomadaire