J. M. Nickell's botanical ready reference : especially designed for druggists and physicians : containing all of the botanical drugs known up to the present time, giving their medical properties, and all of their botanical, common, pharmacopoeal and German common (in German) names /

Mode of access: Internet.

Remarks on the uses of some of the bazaar medicines and common medical plants of India : with a full index of diseases, indicating their treatment by these and other agents procurable throughout India : to which are added directions for treatment in cases of drowning, snake-bites &c. /

Reprint. Originally published: 5th ed. London, J.&A. Churchill, 1897.

Herbal simples approved for modern uses of cure /

On cover: "New and enlarged edition."

Manuel des plantes usuelles indigènes, ou, Histoire abrégée des plantes de France : distribuées d'après une nouvelle méthode : contenant leurs propriétés et leurs usages en médecine, dans la pharmacie et dans l'économie domestique : suivi de recherches et d'observations sur l'emploi de plusieurs espèces, qui, dans la pratique de la médecine, peuvent remplacer un certain nombre de substances exotiques /

"Deuxième partie" has separate paging and t.p.: Recherches et observations sur l'emploi de plusieurs plantes de France ...

Specimen inaugurale sistens medicamenta graveolentia /

Also published in Linné's Amoenitates academicae, v. 5, ed. 1, 1760; ed. 2, 1788, p. 148-173: Gilibert's Systema plantarum Europæ, v. 6, 1786, p. 181-205.

Flore médicale /

Mode of access: Internet.

English physician enlarged : with three hundred and sixty-nine medicines, made of English herbs, that were not in any impression until this : being an astrologo-physical discourse of the vulgar herbs of this nation; containing a compleat method of physick, whereby a man may preserve his body in health, or cure himself, being sick ... /

Signatures: A-R¹²

Systema materiae medicae vegetabilis Brasiliensis /

Addenda et emendanda inserted.

Grundriss der pharmakochemie,

Mode of access: Internet.

Memoranda Medica of John Perkins, 1750-1773 (inclusive)

Contains notes written by Dr. John Perkins (1698-1781) from 1750 to 1773 on physiology, materia medica, and illness, including symptoms, causes, and treatment of conditions like mumps, dysentery, dropsy, and rheumatism. Also includes observations on children and on various bodily functions. There is an index at the end of the volume.

Nuevos elementos de therapéutica, y de materia médica : seguidos de un nuevo ensayo sobre el arte de formular /

Mode of access: Internet.

Curso de materia médica o de farmacologíia : traducido del que escribió en francés /

Mode of access: Internet.

Speckle-type POZ protein mutations interrupt tumor suppressor function of speckle-type POZ protein in prostate cancer by affecting androgen receptor degradation

Large scale exome sequencing studies have revealed regions of the genome, which contribute to the castrate resistant prostate cancer (CRPC) phenotype. [1],[2],[3] Such studies have identified mutations in genes, which may have diagnostic/prognostic potential, or which may be targeted therapeutically. Two of these genes include the androgen receptor (AR) and speckle-type POZ protein (SPOP) genes. However, the findings from these exome sequencing studies can only be translated therapeutically once the functional consequences of these mutations have been determined. Here, we highlight the recent study by An et al. [4] which investigated the functional effects of mutations in the SPOP gene that were identified in the aforementioned exome sequencing studies, particularly in the context of SPOP-mediated degradation of the AR.

Aspects of the in vitro bioactivity and antimicrobial properties of Ag+- and Zn2+-exchanged 11 Å tobermorites

11 Å tobermorite, Ca5Si6O16(OH)2 · 4H2O, is a layer lattice ion exchange mineral whose potential as a carrier for Ag+ and Zn2+ ions in antimicrobial, bioactive formulations has not yet been explored. In view of this, the in vitro bioactivity of Ag+- and Zn2+-exchanged 11 Å tobermorites and their bactericidal action against S. aureus and P.aeruginosa are reported. The in vitro bioactivity of the synthetic unsubstituted tobermorite phase was confirmed by the formation of bone-like hydroxycarbonate apatite (HCA) on its surface within 48 h of contact with simulated body fluid. The substitution of labile Ag+ ions into the tobermorite lattice delayed the onset of HCA-formation to 72 h; whereas, the Zn2+-substituted phase failed to elicit an HCA-layer within 14 days. Both Ag+- and Zn2+-exchanged tobermorite phases were found to exhibit marked antimicrobial action against S. aureus and P.aeruginosa, two common pathogens in biomaterial-centred infections.

Aspects of the in vitro bioactivity of hydraulic calcium (alumino)silicate cement

In response to a burgeoning interest in the prospective clinical applications of hydraulic calcium (alumino)silicate cements, the in vitro bioactivity and dissolution characteristics of a white Portland cement have been investigated. The formation of an apatite layer within 6 h of contact with simulated body fluid was attributed to the rapid dissolution of calcium hydroxide from the cement matrix and to the abundance of pre-existing Si-OH nucleation sites presented by the calcium silicate hydrate phase. A simple kinetic model has been used to describe the rate of apatite formation and an apparent pseudo-second-order rate constant for the removal of HPO42- ions frorn solultion has been calculated (k(2) = 5.8 x 10(-4) g mg(-1)). Aspects of the chemistry of hydraulic cements are also discussed with respect to their potential use in the remedial treatment of living tissue. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 90A: 166-174, 2009