Significance of tagI and mfd genes in the virulence of non-typeable <i>Haemophilus influenzaei>

Non-typeable <i>Haemophilus influenzaei> (NTHi) is an opportunist pathogen well adapted to the human upper respiratory tract and responsible for many respiratory diseases. In the human airway, NTHi is exposed to pollutants, such as alkylating agents, that damage its DNA. In this study, we examined the significance of genes involved in the repair of DNA alkylation damage in NTHi virulence. Two knockout mutants, tagI and mfd, encoding N(3)methyladenine-DNA glycosylase I and the key protein involved in transcription-coupled repair, respectively, were constructed and their virulence in a BALB/c mice model was examined. This work shows that N-3-methyladenine-DNA glycosylase I is constitutively expressed in NTHi and that it is relevant for its virulence.

Art i natura a la riba del riu Llobregat

Màster Oficial en Gestió del Patrimoni Cultural

Anàlisi patrimonial de l'Església de Sant Pol: propostes d'intervenció i dinamització

Màster Oficial en Gestió del Patrimoni Cultural

La Biblioteca de Catalunya: una difusió del patrimoni amb visió de futur

Màster Oficial en Estudis Avançats en Història de l'Art. Curs: 2008-2009. Directora: Imma Socias