Some issues relating to the ductility of wrought magnesium alloys

The present work is concerned with gaining a better understanding of the factors that control the ductility of wrought magnesium alloys. The ultimate aim is to develop alloys with vastly improved room temperature formability. It is shown that 3D tomography of fractured tensile specimens reveals disk shaped voids aligned more or less at 45 deg. to the tensile axis. These voids are consistent with twin induced void formation. It is also shown that the double twins that produce such voids form in contradiction to Schmid predictions. Finally, it is demonstrated that low levels of rare-earth additions leads to vastly improved texture and ductility in extrusions, as they do in rolled sheet.

Requirements for ICAM-1 immunogene therapy of lymphoma.

Intercellular cell adhesion molecule-1 (ICAM-1) is a cell-surface glycoprotein capable of eliciting bidirectional signals that activate signalling pathways in leukocytes, endothelial, and smooth muscle cells. Gene transfer of xenogeneic ICAM-1 into EL-4 lymphomas causes complete tumor rejection; however, it is unknown whether the mechanism responsible involves the "foreignness" of the ICAM-1 transgene, bidirectional signalling events, ICAM-1-receptor interaction, or a combination of the latter. To begin to address this question, we constructed four different therapeutic expression vectors encoding full-length ICAM-1, and forms in which the N-terminal ligand-binding domains and cytoplasmic tail had been deleted. Mouse EL-4 tumors (0.5 cm in diameter), which actively suppress the immune response, were significantly inhibited in their growth following injection of expression plasmids encoding either full-length xenogenic (human) ICAM-1, or a functional cytoplasmic domain-deficient form that retains ligand-binding activity. Efficacy of ICAM-1-mediated antitumor immunity was significantly augmented by administration of the antivascular drug 5,6-dimethylxanthenone-4-acetic acid (DMXAA), which suppressed blood supply to the tumor, leading to enhanced leukocyte infiltration, and complete tumor eradication in a gene dosage and CD8(+) T cell and NK cell-dependent fashion. Generation of potent cytotoxic T cell (CTL)-mediated antitumor immunity was reflected by ICAM-1-facilitated apoptosis of tumor cells in situ. In contrast, nonfunctional ICAM-1 lacking the N-terminal ligand-binding Ig domain failed to generate antitumor immunity, even in the presence of DMXAA. These studies demonstrate that ICAM-1-stimulated antitumor immunity can overcome tumor-mediated immunosuppression, particularly when employed in combination with an attack on the tumor vasculature. The ligand-binding domain of ICAM-1 is essential for generating antitumor immunity, whereas the cytoplasmic domain and bidirectional activation of tumor signalling pathways are not essential.

Thermal comfort adaptation in outdoor places

The level of international migration has been growing in the last decades creating a plurality of cultures and inspiring a multicultural nature in global cities (O'Byrne, 1997; Short and Kim, 1999; Hawkins, 2006). This created new challenges in urban planning or the management of the coexistence of different people that are having different characteristics shaping their unique identity and needs in shared places. Being the urban stages where the social interactions happen, public places are considered important parts of cities (Thompson, 2002; Varna, 2009). These places can contribute to enhance the quality of life within cities, or contrarily increase isolation and social exclusion (Lo et al.; 2003). As agreed by researchers the users’ state of comfort gives a good indication for how successful is the public outdoor places (Rosheidat et al.; 2008; Kwong et al.; 2009; Aljawabra and Nikolopoulou, 2010). In order to create a successful open space usable by all members of a community, urban designers need to satisfy their thermal comfort needs in its wider meaning according to a variety of users (Knez and Thorsson, 2006; Thorsson et al.; 2007). While assessing the thermal comfort, in addition to the strong influence of the microclimatic parameters, the term thermal adaptation seems to becoming increasingly important. The thermal comfort adaption is then a considerable issue in design guidelines of outdoor environments (Nikolopoulou and Steemers, 2003). The main aim of the research is to examine the influence of thermal adaptation and environmental attitude on participants’ thermal requirements in outdoor public places. It focuses on understanding the effect of adaptation on the thermal comfort perception of immigrants. The research methodology of the research is provided through quantitative analysis of a case study. The findings of thermal comfort investigations could be applied into improving the quality of urban areas in order to increase the outdoor activities of citizens and use of outdoor places.

Locating the semiotic power of multimodality

This article reports research that attempts to characterize what is powerful about digital multimodal texts. Building from recent theoretical work on understanding the workings and implications of multimodal communication, the authors call for a continuing empirical investigation into the roles that digital multimodal texts play in real-world contexts, and they offer one example of how such investigations might be approached. Drawing on data from the practice of multimedia digital storytelling, specifically a piece titled “Lyfe-N-Rhyme,” created by Oakland, California, artist Randy Young (accessible at http://www.oaklanddusty.org/videos.php), the authors detail the method and results of a fine-grained multimodal analysis, revealing semiotic relationships between and among different, copresent modes. It is in these relationships, the authors argue, that the expressive power of multimodality resides.

Diversity and thermal comfort in outdoor places

Sustainable cities should be livable cities where people from different backgrounds and with different aspirations can meet and interact with each other. Public places being the urban stages where the social interactions happen are considered important parts of cities (Thompson, 2002; Varna, 2009). They can contribute to enhance the quality of life within cities, or contrarily increase isolation and social exclusion (Lo et al., 2003). As a consequence of globalization and the development of global cities, the level of international migration has been growing in the last decades creating a plurality of different cultures in global cities and inspiring in such cities a multicultural nature (O'Byrne, 1997; Short and Kim, 1999; Hawkins, 2006). This created new challenges in urban planning or the management of the coexistence of different people that are having different characteristics that shape their unique identity and needs in the shared spaces (Sandercock, 2004). Ideally, in order to invite a diversity of users, urban outdoor places should provide significant functional and physical qualities, and accessibility to them, which induce the fulfillment of physiological, psychological and social needs (Carr et al., 1992; Jacobs, 1993; Sandholz, 2007). Users’ state of comfort as stated by researchers gives a good indication for how successful is the public outdoor places (Rosheidat et al., 2008; Kwong et al., 2009; Aljawabra and Nikolopoulou, 2010). In order to create a successful open space usable by all members of a community, urban designers need to satisfy their comfort needs in its wider meaning according to a variety of different ages, genders and cultural backgrounds (Knez and Thorsson, 2006; Thorsson et al., 2007). The main aim of the research is to examine the influence of culture and environmental attitude on participants’ thermal requirements in outdoor public places. The paper explores the variables that constitute a successful multicultural design, issues of cultural complexity, and the measuring comfort in specific outdoor public place. Qualitative analysis of a case study provides the main research methodology of the research. The conclusion will provide a set of criteria that guide future design and development of a successful shared outdoor public places.

A study protocol of a randomised controlled trial incorporating a health economic analysis to investigate if additional allied health services for rehabilitation reduce length of stay without compromising patient outcomes

Background
Reducing patient length of stay is a high priority for health service providers. Preliminary information suggests additional Saturday rehabilitation services could reduce the time a patient stays in hospital by three days. This large trial will examine if providing additional physiotherapy and occupational therapy services on a Saturday reduces health care costs, and improves the health of hospital inpatients receiving rehabilitation compared to the usual Monday to Friday service. We will also investigate the cost effectiveness and patient outcomes of such a service.
Methods/Design A randomised controlled trial will evaluate the effect of providing additional physiotherapy and occupational therapy for rehabilitation. Seven hundred and twelve patients receiving inpatient rehabilitation at two metropolitan sites will be randomly allocated to the intervention group or control group. The control group will receive usual care physiotherapy and occupational therapy from Monday to Friday while the intervention group will receive the same amount of rehabilitation as the control group Monday to Friday plus a full physiotherapy and occupational therapy service on Saturday. The primary outcomes will be patient length of stay, quality of life (EuroQol questionnaire), the Functional Independence Measure (FIM), and health utilization and cost data. Secondary outcomes will assess clinical outcomes relevant to the goals of therapy: the 10 metre walk test, the timed up and go test, the Personal Care Participation Assessment and Resource Tool (PC PART), and the modified motor assessment scale. Blinded assessors will assess outcomes at admission and discharge, and follow up data on quality of life, function and health care costs will be collected at 6 and 12 months after discharge. Between group differences will be analysed with analysis of covariance using baseline measures as the covariate. A health economic analysis will be carried out alongside the randomised controlled trial.
Discussion This paper outlines the study protocol for the first fully powered randomised controlled trial incorporating a health economic analysis to establish if additional Saturday allied health services for rehabilitation inpatients reduces length of stay without compromising discharge outcomes. If successful, this trial will have substantial health benefits for the patients and for organizations delivering rehabilitation services.

Zonal banning and public order in urban Australia

In recent years, Australian governments of various ideological persuasions at local, state and territory and federal levels have introduced a range of zonal governing techniques to manage the flow of people in urban spaces. Zonal governance involves the identification and formal declaration of a specific urban geographic region to enable police and security personnel to deploy special powers and allied forms of surveillance technologies as a supplement to their conventional public order maintenance functions.

Despite the impetus towards open flows or movement within sovereign territories or larger territorial groupings, such as the European Union, considerable governmental effort has been directed towards the use of new forms of criminal law to re-territorialize urban space through new administrative, property law and regulatory measures. These low-level spatial demarcations introduce various supplementary police powers and discretionary procedures that enhance surveillance within a declared area to increase the level of contemporary urban security. Of particular concern is the legal right to ban or exclude “undesirable” individuals and groups from entering or using certain designated urban zones, to prevent antisocial or violent behavior usually associated with alcohol consumption.

To date, most discussion of the impact of banning and related surveillance measures focuses on illegal migration through ports of entry into sovereign nations and the commensurate burdens this creates for both citizens and non-citizens to authenticate their movements at national geographic borders. This logic is permeating more localized forms of regulation adopted by Australian local and mid-tier state and territory governments to control the movement of people in and out of major event sites and in the urban night-time economy.

A survey of recent reforms in the state of Victoria reveals how this new logic of mass-surveillance aims to promote greater levels of urban security while reshaping the conventional order maintenance functions of both the public and private police. This chapter describes these procedures and their impact in sanctioning the efficient screening of people to promote order in specific zones within the contemporary Australian urban environment, at the expense of more progressive and inclusive crime prevention initiatives. We focus on two exemplars of the intensification of surveillance through zonal governance techniques: ‘major events’ and ‘designated alcohol zones’.